(Q27759085)

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Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

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Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide (English)

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crystal structure

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1 reference

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author name string

Y Xue

1

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P Björquist

2

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T Inghardt

3

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M Linschoten

4

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D Musil

5

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L Sjölin

6

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J Deinum

7

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publication date

15 May 1998

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6

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5

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627-36

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Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

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7 January 2021

based on heuristic

inferred from DOI database lookup

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

1 reference

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inferred from DOI database lookup

Biological implications of a 3 A structure of dimeric antithrombin

1 reference

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based on heuristic

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Characterisation of the complex of plasminogen activator inhibitor type 1 with tissue-type plasminogen activator by mass spectrometry and size-exclusion chromatography.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

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The serpin-proteinase complex revealed

1 reference

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7 January 2021

based on heuristic

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Major proteinase movement upon stable serpin-proteinase complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

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Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Epitopes on plasminogen activator inhibitor type-1 important for binding to tissue plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

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Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the binding site for a low-molecular-weight inhibitor of plasminogen activator inhibitor type 1 by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis of latency in plasminogen activator inhibitor-1

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystallization and X-ray diffraction data of the cleaved form of plasminogen activator inhibitor-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Serpin-protease complexes are trapped as stable acyl-enzyme intermediates

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A.

1 reference

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Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The acid stabilization of plasminogen activator inhibitor-1 depends on protonation of a single group that affects loop insertion into beta-sheet A.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of ovalbumin as a model for the reactive centre of serpins

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

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Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction

1 reference

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7 January 2021

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Separation of active and inactive forms of recombinant human plasminogen activator inhibitor type 1 (PAI-1) expressed in Chinese hamster ovary cells: comparison with native human PAI-1

1 reference

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7 January 2021

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[33] AMoRe: An automated molecular replacement program package

1 reference

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7 January 2021

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Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900064-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

1 reference

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7 January 2021

based on heuristic

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

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7 January 2021

based on heuristic

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10.1016/S0969-2126(98)00064-1

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