(Q27742255)

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Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

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Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors (English)

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molecular design

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1 reference

based on heuristic

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Jörg Stürzebecher

4

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J Stürzebecher

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author name string

M Renatus

1

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W Bode

2

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R Huber

3

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D Prasa

5

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S Fischer

6

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U Kohnert

7

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M T Stubbs

8

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publication date

29 August 1997

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Journal of Biological Chemistry

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272

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35

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21713-9

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The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator

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https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Serpin-resistant mutants of human tissue-type plasminogen activator

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https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1

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https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Origins of the specificity of tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Structure of human des(1-45) factor Xa at 2.2 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Biochemical properties of the kringle 2 and protease domains are maintained in the refolded t-PA deletion variant BM 06.022

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

AMoRe: an automated package for molecular replacement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Mapping of the catalytic site of CHO‐t‐PA and the t‐PA variant BM 06.022 by synthetic inhibitors and substrates

1 reference

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21 January 2018

The crystal structure of the catalytic domain of human urokinase-type plasminogen activator

1 reference

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21 January 2018

Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

1 reference

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21 January 2018

Accurate bond and angle parameters for X-ray protein structure refinement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Distinct mechanisms contribute to stringent substrate specificity of tissue-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Making tissue-type plasminogen activator more fibrin specific

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.35.21713

21 January 2018

Identifiers

10.1074/JBC.272.35.21713

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