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CIViC database

an open access, open source, community-driven web resource for Clinical Interpretation of Variants in Cancer

CIVICdb
Clinical Interpretation of Variants in Cancer

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Washington University School of Medicine

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Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma

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Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors

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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

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AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients

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KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

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Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

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An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells

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ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma

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A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab

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Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

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Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

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Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group

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Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma

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BRAF mutations in hairy-cell leukemia

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Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers

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Class III β-tubulin counteracts the ability of paclitaxel to inhibit cell migration

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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

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Genome sequencing identifies a basis for everolimus sensitivity

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

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Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

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The PI3K pathway as drug target in human cancer

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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

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IDH1 and IDH2 mutations in gliomas

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

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The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis

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Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

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Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer

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The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

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Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study

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DNMT3A Mutations in Acute Myeloid Leukemia

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CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant

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Acquired Resistance to Crizotinib from a Mutation in CD74 – ROS1

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The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non-Small Cell Lung Cancer

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Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

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New IDH1 mutant inhibitors for treatment of acute myeloid leukemia

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Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State

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MEK1 mutations confer resistance to MEK and B-RAF inhibition

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Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma

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Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.

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Cyclin E in human cancers.

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A novel fusion gene, SYT-SSX4, in synovial sarcoma.

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Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors

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Cyclin D2, but not cyclin D1, overexpression closely correlates with gastric cancer progression and prognosis

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

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Diagnostic gold standard for soft tissue tumours: morphology or molecular genetics?

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Malignant peripheral nerve sheath tumors with t(X;18). A pathologic and molecular genetic study

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Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: a Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

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TP53 mutation is related to poor prognosis after radiotherapy, but not surgery, in squamous cell carcinoma of the head and neck

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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TP53 polymorphism, HPV infection, and risk of cervical cancer.

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Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

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Fusions of the SYT and SSX genes in synovial sarcoma

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All trans retinoic acid in acute promyelocytic leukemia

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The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma

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Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients.

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Overexpression of pRB in human pancreatic carcinoma cells: function in chemotherapy-induced apoptosis

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VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma

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KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size

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The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma

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SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer

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Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor

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Cyclin E and survival in patients with breast cancer

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Novel targeted therapies for Bcr-Abl positive acute leukemias: beyond STI571.

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Specific p53 mutations predict poor prognosis in oral squamous cell carcinoma

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Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.

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AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

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A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

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RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.

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The effect of flavopiridol on the growth of p16+ and p16- melanoma cell lines.

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TP53 polymorphisms and lung cancer risk: a systematic review and meta-analysis

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Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

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Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome

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Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme

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Promoter methylation of cyclin D2 gene in gastric carcinoma

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Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

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Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer.

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Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions

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Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia

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CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations

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Trastuzumab plus docetaxel in HER2/neu-positive non-small-cell lung cancer: a California Cancer Consortium screening and phase II trial

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Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor.

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients

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A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential

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The two major imatinib resistance mutations E255K and T315I enhance the activity of BCR/ABL fusion kinase.

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Thymic carcinoma with overexpression of mutated KIT and the response to imatinib

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Expression and mutational status of c-kit in small-cell lung cancer: prognostic relevance

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

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Topoisomerase-II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel

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FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L).

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Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

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Racial differences in the overexpression of epidermal growth factor type II receptor (HER2/neu): a major prognostic indicator in uterine serous papillary cancer

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MGMT gene silencing and benefit from temozolomide in glioblastoma

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Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line

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Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer

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Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group

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Mutation and methylation analysis of TP53 in adrenal carcinogenesis.

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PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib

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RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

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Cyclin D1 in breast cancer pathogenesis

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Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype

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Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

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Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

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Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells

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Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer

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In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor

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Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

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The c-kit (CD117) sequence variation M541L, but not N564K, is frequent in the general population, and is not associated with CML in Caucasians

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Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

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Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study

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PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

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Implications of NRAS mutations in AML: a study of 2502 patients

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Correlation of basic fibroblast growth factor expression with the invasion and the prognosis of oral squamous cell carcinoma

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Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

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mdr-1 single nucleotide polymorphisms in ovarian cancer tissue: G2677T/A correlates with response to paclitaxel chemotherapy

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A case of c-kit positive high-grade stromal endometrial sarcoma responding to Imatinib Mesylate.

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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

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Benefit from adjuvant tamoxifen therapy in primary breast cancer patients according oestrogen receptor, progesterone receptor, EGF receptor and HER2 status

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Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

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KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours

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Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate

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Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer

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High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a

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The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

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Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib

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XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer

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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

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Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas.

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Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders

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Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation

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Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells

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Expression of hypoxia-inducible factor (HIF)-1alpha as a biomarker of outcome in soft-tissue sarcomas

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Lapatinib plus capecitabine for HER2-positive advanced breast cancer

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Clinical significance of TP53 mutation in myeloma

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L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

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Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer

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Aspirin and the risk of colorectal cancer in relation to the expression of COX-2.

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Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer

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Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

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FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome.

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Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

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Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications

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The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia

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Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

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Cetuximab for the treatment of colorectal cancer.

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Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study.

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Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

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KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab.

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Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia

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Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling

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BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors

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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

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Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.

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Major response to imatinib mesylate in KIT-mutated melanoma.

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MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer

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Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

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Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors

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Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma

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Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy

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Clinical and biological significance of RAS mutations in multiple myeloma.

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Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu

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Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study

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Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party

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Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer.

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Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer

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EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer

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Detection of complete response to imatinib mesylate (Glivec/Gleevec) with 18F-FDG PET/CT for low-grade endometrial stromal sarcoma

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Penetrance analysis of the PALB2 c.1592delT founder mutation

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Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up

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The polymorphisms of TS and MTHFR predict survival of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population.

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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

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Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation

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Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma

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Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study

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Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors

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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

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Activating mutations in ALK provide a therapeutic target in neuroblastoma

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Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts.

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K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

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Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor

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Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma

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Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group

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Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.

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HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy

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Aurora kinases as prognostic biomarkers in ovarian carcinoma.

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Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients

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Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group

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PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

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DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.

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A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms

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Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a german breast group 26/breast international group 03-05 study.

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FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro

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Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients

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Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics

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ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes

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Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

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SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

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Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML.

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Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma: a rare clinicopathologic entity with poor prognosis

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Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma.

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A novel K-ras mutation in colorectal cancer. A case report and literature review

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TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).

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Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity

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Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates

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Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

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KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

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Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers

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IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report

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Genotype-phenotype correlation of patients with multiple endocrine neoplasia type 2 in Japan.

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Deficiency of the ATM protein expression defines an aggressive subgroup of B-cell chronic lymphocytic leukemia.

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Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival

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Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer

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EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma

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SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma

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Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma

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Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy

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Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: an important role for mutations in minor clones

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Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: a Gynecologic Oncology Group study

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MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.

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Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma

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IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide

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KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803

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p53 genotype predicts response to chemotherapy in patients with squamous cell carcinoma of the esophagus

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TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.

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Alterations of the Notch pathway in lung cancer.

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Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

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Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment

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Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer

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The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

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Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer

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FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

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Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer

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Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts

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HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers

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Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor

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Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer

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Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study

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Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

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IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.

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Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

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IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

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Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I).

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Human papillomavirus and survival of patients with oropharyngeal cancer.

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BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review

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Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

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FGFR3 mutational status and protein expression in patients with bladder cancer in a Jordanian population

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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

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A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

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Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

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UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy

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CXCR4, a potential predictive marker for docetaxel sensitivity in gastric cancer.

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The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary

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TP53 mutation and survival in chronic lymphocytic leukemia

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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

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Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3

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The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo.

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IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status

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PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.

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EGFR gene copy number as a predictive biomarker for patients receiving tyrosine kinase inhibitor treatment: a systematic review and meta-analysis in non-small-cell lung cancer

0 references

Homogeneous EGFR amplification defines a subset of aggressive Barrett's adenocarcinomas with poor prognosis.

0 references

Activity of IPI-504, a Novel Heat-Shock Protein 90 Inhibitor, in Patients With Molecularly Defined Non–Small-Cell Lung Cancer

0 references

Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab

0 references

Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab

0 references

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

0 references

Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.

0 references

EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

0 references

The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated Cancers

0 references

Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study

0 references

BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation

0 references

A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma

0 references

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo.

0 references

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

0 references

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

0 references

KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.

0 references

Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis

0 references

The Hsp90 inhibitor IPI-504 rapidly lowers EML4–ALK levels and induces tumor regression in ALK-driven NSCLC models

0 references

Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer

0 references

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

0 references

RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group

0 references

Crizotinib in anaplastic large-cell lymphoma

0 references

Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: the association with treatment efficacy of pemetrexed.

0 references

Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

0 references

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

0 references

Estrogen receptor and progesterone receptor as predictive biomarkers of response to endocrine therapy: a prospectively powered pathology study in the Tamoxifen and Exemestane Adjuvant Multinational trial

0 references

Anti-tumor activity of motesanib in a medullary thyroid cancer model

0 references

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

0 references

DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer

0 references

Treatment outcome of all-trans retinoic acid/anthracycline combination chemotherapy and the prognostic impact of FLT3/ITD mutation in acute promyelocytic leukemia patients

0 references

Prognostic significance of truncating TP53 mutations in head and neck squamous cell carcinoma

0 references

Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial

0 references

Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas

0 references

Use of whole-genome sequencing to diagnose a cryptic fusion oncogene

0 references

Prognostic impact of FLT3-ITD load in NPM1 mutated acute myeloid leukemia

0 references

The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations

0 references

NRAS-mutant melanoma: response to chemotherapy.

0 references

Both BRAF V600E mutation and older age (≥ 65 years) are associated with recurrent papillary thyroid cancer

0 references

The prognostic significance of IDH2 mutations in AML depends on the location of the mutation

0 references

Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment

0 references

Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification

0 references

Anaplastic lymphoma kinase translocation: a predictive biomarker of pemetrexed in patients with non-small cell lung cancer

0 references

Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment

0 references

Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer

0 references

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

0 references

Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification

0 references

Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1.

0 references

EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target

0 references

Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia

0 references

A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors

0 references

TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics

0 references

Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers

0 references

A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations

0 references

Impact of KRAS mutations on clinical outcomes in pancreatic cancer patients treated with first-line gemcitabine-based chemotherapy

0 references

ATP-binding cassette B1 gene polymorphisms, mRNA expression and chemosensitivity to paclitaxel in non-small cell lung cancer cells

0 references

Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers

0 references

BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer

0 references

An EZH2 polymorphism is associated with clinical outcome in metastatic colorectal cancer patients

0 references

Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis

0 references

ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

0 references

C609T polymorphism of NAD(P)H quinone oxidoreductase 1 as a predictive biomarker for response to amrubicin

0 references

Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

0 references

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

0 references

IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome

0 references

Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma

0 references

First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

0 references

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

0 references

Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic study of 277 patients

0 references

Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen

0 references

EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study

0 references

Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.

0 references

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

0 references

Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.

0 references

TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence.

0 references

Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study

0 references

DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia

0 references

A KRAS variant is a biomarker of poor outcome, platinum chemotherapy resistance and a potential target for therapy in ovarian cancer

0 references

Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer

0 references

Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor

0 references

Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212.

0 references

Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management

0 references

NRAS mutation status is an independent prognostic factor in metastatic melanoma

0 references

Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer

0 references

BRCA1 is an essential mediator of vinorelbine-induced apoptosis in mesothelioma.

0 references

Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway.

0 references

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.

0 references

ROS1 rearrangements define a unique molecular class of lung cancers

0 references

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma

0 references

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

0 references

Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome

0 references

Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method.

0 references

Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial

0 references

Sunitinib therapy for melanoma patients with KIT mutations

0 references

mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors

0 references

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

0 references

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

0 references

Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

0 references

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

0 references

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

0 references

Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia

0 references

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

0 references

Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background

0 references

Influence of MDR1 gene codon 3435 polymorphisms on outcome of platinum-based chemotherapy for advanced non small cell lung cancer

0 references

The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells

0 references

Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu.

0 references

Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer

0 references

Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules

0 references

Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum

0 references

Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.

0 references

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma

0 references

Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence

0 references

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

0 references

Thymidylate synthase mRNA levels in plasma and tumor as potential predictive biomarkers for raltitrexed sensitivity in gastric cancer

0 references

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

0 references

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

0 references

TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group

0 references

FOXP3 expression in cancer cells and anthracyclines efficacy in patients with primary breast cancer treated with adjuvant chemotherapy in the phase III UNICANCER-PACS 01 trial

0 references

The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study

0 references

A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

0 references

Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial

0 references

Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era.

0 references

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

0 references

Preoperative chemotherapy plus trastuzumab, lapatinib, or both in human epidermal growth factor receptor 2-positive operable breast cancer: results of the randomized phase II CHER-LOB study

0 references

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

0 references

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

0 references

High expression of TIMP-1 in human breast cancer tissues is a predictive of resistance to paclitaxel-based chemotherapy

0 references

Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model

0 references

Genetic polymorphism of XRCC1 Arg399Gln is associated with survival in non-small-cell lung cancer patients treated with gemcitabine/platinum.

0 references

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

0 references

Somatic STAT3 mutations in large granular lymphocytic leukemia

0 references

Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma

0 references

Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.

0 references

Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: a meta-analysis

0 references

Altered p16(INK4) and RB1 Expressions Are Associated with Poor Prognosis in Patients with Nonsmall Cell Lung Cancer

0 references

Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy

0 references

The associations between RAS mutations and clinical characteristics in follicular thyroid tumors: new insights from a single center and a large patient cohort

0 references

Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas

0 references

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

0 references

Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia

0 references

Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors

0 references

RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures

0 references

BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors

0 references

The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis

0 references

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial

0 references

Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial

0 references

Association of KRAS and EGFR mutations with survival in patients with advanced lung adenocarcinomas

0 references

Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab

0 references

LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin

0 references

Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR

0 references

ABCB1, FCGR2A, and FCGR3A polymorphisms in patients with HER2-positive metastatic breast cancer who were treated with first-line taxane plus trastuzumab chemotherapy

0 references

Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

0 references

MYD88 L265P somatic mutation in Waldenström's macroglobulinemia.

0 references

Impact of the specific mutation in KRAS codon 12 mutated tumors on treatment efficacy in patients with metastatic colorectal cancer receiving cetuximab-based first-line therapy: a pooled analysis of three trials.

0 references

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

0 references

Prognostic value of K-ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer

0 references

ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome

0 references

Trastuzumab emtansine for HER2-positive advanced breast cancer

0 references

U2AF1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome

0 references

Overwhelming response to Dabrafenib in a patient with double BRAF mutation (V600E; V600M) metastatic malignant melanoma

0 references

AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines

0 references

Association between expression of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase and efficacy of pemetrexed in advanced non-small cell lung cancer

0 references

Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.

0 references

The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial.

0 references

CDKN2A (p16) promoter hypermethylation influences the outcome in young lung cancer patients

0 references

Elucidating distinct roles for NF1 in melanomagenesis

0 references

A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALK fusion gene

0 references

Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer.

0 references

Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells

0 references

Ponatinib in refractory Philadelphia chromosome-positive leukemias

0 references

Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

0 references

Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors

0 references

Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma

0 references

High expression of class III β-tubulin predicts good response to neoadjuvant taxane and doxorubicin/cyclophosphamide-based chemotherapy in estrogen receptor-negative breast cancer

0 references

Activating HER2 mutations in HER2 gene amplification negative breast cancer

0 references

Recurrent SETBP1 mutations in atypical chronic myeloid leukemia

0 references

A potent combination of the novel PI3K Inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: long-lasting responses after treatment withdrawal

0 references

Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: a GINECO group study.

0 references

Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: analysis of data from the EXTREME and CRYSTAL studies

0 references

Biomarkers for the clinical management of breast cancer: international perspective

0 references

Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models

0 references

A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition

0 references

The dominant role of G12C over other KRAS mutation types in the negative prediction of efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer.

0 references

Prognostic relevance of AIB1 (NCoA3) amplification and overexpression in breast cancer

0 references

Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer

0 references

Prognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort.

0 references

Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation

0 references

Phosphorylation of 4E-BP1 predicts sensitivity to everolimus in gastric cancer cells

0 references

The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.

0 references

Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer.

0 references

Advanced ovarian cancer: what should be the standard of care?

0 references

HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients

0 references

Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes

0 references

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

0 references

Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer

0 references

Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer

0 references

MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study

0 references

Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD

0 references

Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo

0 references

Multicenter phase I trial of the mitogen-activated protein kinase 1/2 inhibitor BAY 86-9766 in patients with advanced cancer

0 references

KRAS mutation status is not predictive for objective response to anti-EGFR treatment with erlotinib in patients with advanced pancreatic cancer

0 references

PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: a meta-analysis

0 references

The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer.

0 references

The somatic affairs of BRAF: tailored therapies for advanced malignant melanoma and orphan non-V600E (V600R-M) mutations.

0 references

Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers

0 references

Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact

0 references

Correlation of p53 status with the response to chemotherapy-based treatment in esophageal cancer: a meta-analysis

0 references

Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer

0 references

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

0 references

Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer

0 references

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

0 references

Identification of targetable FGFR gene fusions in diverse cancers.

0 references

Somatic mutations in exocrine pancreatic tumors: association with patient survival

0 references

SF3B1 mutations in chronic lymphocytic leukemia

0 references

Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma.

0 references

Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer

0 references

Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.

0 references

Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08).

0 references

A patient with lung adenocarcinoma and RET fusion treated with vandetanib

0 references

Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study.

0 references

Targeting the BRAF V600E mutation in multiple myeloma

0 references

Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers

0 references

Insulin-like growth factor-1 receptor (IGF-1R) as a biomarker for resistance to the tyrosine kinase inhibitor gefitinib in non-small cell lung cancer

0 references

Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network

0 references

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).

0 references

HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas

0 references

CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study

0 references

Thymidylate synthase gene copy number as a predictive marker for response to pemetrexed treatment of lung adenocarcinoma

0 references

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

0 references

Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer

0 references

Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O 3) in acute promyelocytic leukemia

0 references

Integrated multimodal genetic testing of Ewing sarcoma--a single-institution experience

0 references

Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma

0 references

Nivolumab plus ipilimumab in advanced melanoma

0 references

Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.

0 references

Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial.

0 references

Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors

0 references

Exon 4 deletion variant of epidermal growth factor receptor enhances invasiveness and cisplatin resistance in epithelial ovarian cancer

0 references

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

0 references

Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin

0 references

A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509.

0 references

Comprehensive molecular characterization of clear cell renal cell carcinoma

0 references

Integrated molecular analysis of clear-cell renal cell carcinoma

0 references

Impact of MET expression on outcome in BRAF(V600E/K) advanced melanoma

0 references

Fibroblast growth factor receptor 1 (FGFR1) copy number is an independent prognostic factor in non-small cell lung cancer

0 references

Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth

0 references

Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.

0 references

KRAS as prognostic biomarker in metastatic colorectal cancer patients treated with bevacizumab: a pooled analysis of 12 published trials

0 references

Tyrosine kinase inhibitor therapy induces remission in a patient with refractory EBF1-PDGFRB-positive acute lymphoblastic leukemia.

0 references

A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

0 references

Clinical implications of U2AF1 mutation in patients with myelodysplastic syndrome and its stability during disease progression.

0 references

NRAS and BRAF mutations in melanoma-associated nevi and uninvolved nevi.

0 references

Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells

0 references

TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression.

0 references

The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma.

0 references

PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.

0 references

Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy

0 references

PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity

0 references

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

0 references

TERT promoter mutations in primary and secondary glioblastomas.

0 references

Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.

0 references

Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia.

0 references

PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt activation

0 references

The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma

0 references

EGFR exon-level biomarkers of the response to bevacizumab/erlotinib in non-small cell lung cancer

0 references

Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.

0 references

The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere

0 references

High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma

0 references

Loss of NAPRT1 expression by tumor-specific promoter methylation provides a novel predictive biomarker for NAMPT inhibitors

0 references

Fibroblast growth factor receptor 1 as a putative therapy target in colorectal cancer

0 references

A novel BRCA1 mutation in a patient with breast and ovarian cancer: A case report

0 references

HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab

0 references

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.

0 references

Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer

0 references

Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.

0 references

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

0 references

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

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RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib

0 references

Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement

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Ponatinib is a pan-BCR-ABL kinase inhibitor: MD simulations and SIE study

0 references

p27 and BCL2 expression predicts response to chemotherapy in head and neck squamous cell carcinomas

0 references

Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas

0 references

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity

0 references

Assessment of the topoisomerase I gene copy number as a predictive biomarker of objective response to irinotecan in metastatic colorectal cancer

0 references

A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition

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ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers.

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SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer.

0 references

Association of matrix metalloproteinase 2 plasma level with response and survival in patients treated with bevacizumab for recurrent high-grade glioma

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Crizotinib in refractory ALK-positive diffuse large B-cell lymphoma: a case report with a short-term response

0 references

BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition

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The BRAF(V600E) mutation in papillary thyroid microcarcinoma: does the mutation have an impact on clinical outcome?

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Activation of AR sensitizes breast carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation

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IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL.

0 references

RSF1 and not cyclin D1 gene amplification may predict lack of benefit from adjuvant tamoxifen in high-risk pre-menopausal women in the MA.12 randomized clinical trial

0 references

Therapeutic targeting of cancers with loss of PTEN function

0 references

Prognostic value of BRAF mutations in localized cutaneous melanoma.

0 references

Prognostic value of the BRAF V600E mutation in papillary thyroid carcinoma

0 references

Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial

0 references

Clinical predictors of response to EGFR tyrosine kinase inhibitors in patients with EGFR-mutant non-small cell lung cancer.

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Oncogenic RIT1 mutations in lung adenocarcinoma

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Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC.

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Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

0 references

CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: an international study of 570 patients

0 references

Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition

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Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy.

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DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome.

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Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma

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Regorafenib in metastatic colorectal cancer.

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Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma

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Immunohistochemistry for BRAF(V600E) antibody VE1 performed in core needle biopsy samples identifies mutated papillary thyroid cancers.

0 references

RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures

0 references

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

0 references

Impact of human papilloma virus infection on the response of head and neck cancers to anti-epidermal growth factor receptor antibody therapy

0 references

Impact of tumor HPV status on outcome in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck receiving chemotherapy with or without cetuximab: retrospective analysis of the phase III EXTREME trial

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Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma

0 references

Dabrafenib and trametinib, alone and in combination for BRAF-mutant metastatic melanoma

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BRAF-V600 mutations have no prognostic impact in stage IV melanoma patients treated with monochemotherapy

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FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors

0 references

Stathmin protein level, a potential predictive marker for taxane treatment response in endometrial cancer

0 references

BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis

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Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

0 references

The predictive role of pretreatment epidermal growth factor receptor T790M mutation on the progression-free survival of tyrosine-kinase inhibitor-treated non-small cell lung cancer patients: a meta-analysis

0 references

Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib

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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

0 references

Response to pemetrexed rechallenge after acquired resistance of EGFR-TKI in a patient with advanced NSCLC.

0 references

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

0 references

EGFR gene copy number as a predictive biomarker for resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer treatment: a meta-analysis

0 references

Recurrent SMARCA4 mutations in small cell carcinoma of the ovary.

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A systematic profile of clinical inhibitors responsive to EGFR somatic amino acid mutations in lung cancer: implication for the molecular mechanism of drug resistance and sensitivity

0 references

Relationship between EGFR expression, EGFR mutation status, and the efficacy of chemotherapy plus cetuximab in FLEX study patients with advanced non-small-cell lung cancer

0 references

The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis

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Ceritinib in ALK-rearranged non-small-cell lung cancer

0 references

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

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Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

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P21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer

0 references

Primary concomitant EGFR T790M mutation predicted worse prognosis in non-small cell lung cancer patients

0 references

Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma

0 references

Comparison of clinical outcomes following gefitinib and erlotinib treatment in non-small-cell lung cancer patients harboring an epidermal growth factor receptor mutation in either exon 19 or 21.

0 references

Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis

0 references

Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia

0 references

Predictive value of CHFR and MLH1 methylation in human gastric cancer

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FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies.

0 references

A practical approach to aid physician interpretation of clinically actionable predictive biomarker results in a multi-platform tumor profiling service

0 references

Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial

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Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients

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Prognostic significance of human papillomavirus in recurrent or metastatic head and neck cancer: an analysis of Eastern Cooperative Oncology Group trials

0 references

Prognostic significance of FLT3 internal tandem duplication, nucleophosmin 1, and CEBPA gene mutations for acute myeloid leukemia patients with normal karyotype and younger than 60 years: a systematic review and meta-analysis.

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Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

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Prognostic value of TP53 gene mutations in myelodysplastic syndromes and acute myeloid leukemia treated with azacitidine

0 references

Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines

0 references

Impact of FLT3(ITD) mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia.

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TET2 gene mutation is unfavorable prognostic factor in cytogenetically normal acute myeloid leukemia patients with NPM1+ and FLT3-ITD - mutations

0 references

Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase III study

0 references

Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib

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Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions

0 references

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

0 references

Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab

0 references

Trastuzumab emtansine is active on HER-2 overexpressing NSCLC cell lines and overcomes gefitinib resistance

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Overexpression of DDX43 mediates MEK inhibitor resistance through RAS Upregulation in uveal melanoma cells

0 references

A randomised, double-blind, placebo-controlled trial of trametinib, an oral MEK inhibitor, in combination with gemcitabine for patients with untreated metastatic adenocarcinoma of the pancreas

0 references

Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro

0 references

Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia

0 references

Epidermal Growth Factor Receptor P753S Mutation in Cutaneous Squamous Cell Carcinoma Responsive to Cetuximab-Based Therapy

0 references

Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial

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Recurrent mutations refine prognosis in chronic lymphocytic leukemia.

0 references

Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations

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TP53 mutational status and cetuximab benefit in rectal cancer: 5-year results of the EXPERT-C trial

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Nuclear survivin expression: a prognostic factor for the response to taxane-platinum chemotherapy in patients with advanced non-small cell lung cancer.

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Targeting TBK1 inhibits migration and resistance to MEK inhibitors in mutant NRAS melanoma

0 references

0 references

Extended Antitumor Response of a BRAF V600E Papillary Thyroid Carcinoma to Vemurafenib

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Association studies of Fcγ receptor polymorphisms with outcome in HER2+ breast cancer patients treated with trastuzumab in NCCTG (Alliance) Trial N9831

0 references

CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors

0 references

Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

0 references

Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group

0 references

Identification of kit(M541L) somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response

0 references

BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence

0 references

Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis

0 references

The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF

0 references

A 3'-UTR KRAS-variant is associated with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma

0 references

Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis

0 references

FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer.

0 references

Schlafen-11 sensitizes colorectal carcinoma cells to irinotecan

0 references

Diagnostic and prognostic TERT promoter mutations in thyroid fine-needle aspiration biopsy.

0 references

Prognostic parameters in uveal melanoma and their association with BAP1 expression

0 references

Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study.

0 references

Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer

0 references

Prognostic value of FGFR gene amplification in patients with different types of cancer: a systematic review and meta-analysis

0 references

AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer

0 references

The genomic landscape of pediatric Ewing sarcoma

0 references

RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells

0 references

UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

0 references

Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status

0 references

HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models

0 references

TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma

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Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study

0 references

TERT gene amplification is associated with poor outcome in acral lentiginous melanoma

0 references

Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib

0 references

Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.

0 references

Crizotinib in ROS1-rearranged non-small-cell lung cancer.

0 references

Combined vemurafenib and cobimetinib in BRAF-mutated melanoma

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p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma

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Afatinib demonstrates remarkable activity against HER2-amplified uterine serous endometrial cancer in vitro and in vivo.

0 references

A phase II study of the efficacy and safety of the combination therapy of the MEK inhibitor refametinib (BAY 86-9766) plus sorafenib for Asian patients with unresectable hepatocellular carcinoma.

0 references

Response and acquired resistance to everolimus in anaplastic thyroid cancer

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PTEN deficiency as a predictive biomarker of resistance to HER2-targeted therapy in advanced gastric cancer.

0 references

Mutational landscape of aggressive cutaneous squamous cell carcinoma

0 references

ASXL1 mutations define a subgroup of patients with acute myeloid leukemia with distinct gene expression profile and poor prognosis: a meta-analysis of 3311 adult patients with acute myeloid leukemia

0 references

Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancer.

0 references

Resistant mutations in CML and Ph(+)ALL - role of ponatinib.

0 references

Cabozantinib overcomes crizotinib resistance in ROS1 fusion-positive cancer

0 references

Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer

0 references

First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors

0 references

Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib

0 references

Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel.

0 references

Improved overall survival in melanoma with combined dabrafenib and trametinib

0 references

A Poorly Differentiated Malignant Neoplasm Lacking Lung Markers Harbors an EML4-ALK Rearrangement and Responds to Crizotinib

0 references

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

0 references

Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations

0 references

Ataxia-telangiectasia-mutated protein kinase levels stratify patients with pancreatic adenocarcinoma into prognostic subgroups with loss being a strong indicator of poor survival

0 references

SF3B1 mutations constitute a novel therapeutic target in breast cancer

0 references

FGFR1 amplification in lung squamous cell carcinoma: a systematic review with meta-analysis

0 references

Breast cancer in a RAD51D mutation carrier: case report and review of the literature

0 references

First-line crizotinib versus chemotherapy in ALK-positive lung cancer

0 references

CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients

0 references

Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer.

0 references

Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib

0 references

Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance)

0 references

Clinical and in vivo evidence that EGFR S768I mutant lung adenocarcinomas are sensitive to erlotinib.

0 references

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

0 references

A neoadjuvant, randomized, open-label phase II trial of afatinib versus trastuzumab versus lapatinib in patients with locally advanced HER2-positive breast cancer

0 references

PACMEL: a phase 1 dose escalation trial of trametinib (GSK1120212) in combination with paclitaxel

0 references

Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models

0 references

Overexpression of ETV4 is associated with poor prognosis in prostate cancer: involvement of uPA/uPAR and MMPs

0 references

In vitro anticancer activity of PI3K alpha selective inhibitor BYL719 in head and neck cancer

0 references

Unique genomic profile of fibrolamellar hepatocellular carcinoma

0 references

Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas.

0 references

A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study

0 references

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy

0 references

Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials

0 references

Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients

0 references

Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells.

0 references

Favorable response to trastuzumab plus irinotecan combination therapy in two patients with HER2-positive relapsed small-cell lung cancer

0 references

Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: results from the EUROS1 cohort

0 references

MDM2 is an important prognostic and predictive factor for platin-pemetrexed therapy in malignant pleural mesotheliomas and deregulation of P14/ARF (encoded by CDKN2A) seems to contribute to an MDM2-driven inactivation of P53.

0 references

EGFR T790M resistance mutation in non small-cell lung carcinoma

0 references

A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer

0 references

Parallel phase Ib studies of two schedules of buparlisib (BKM120) plus carboplatin and paclitaxel (q21 days or q28 days) for patients with advanced solid tumors.

0 references

Predictive role of BRAF mutations in patients with advanced colorectal cancer receiving cetuximab and panitumumab: a meta-analysis

0 references

Epidermal growth factor is a potential biomarker for poor cetuximab response in tongue cancer cells.

0 references

Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer

0 references

Metastatic Extramammary Paget's Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature.

0 references

Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer

0 references

DNAJB1-PRKACA is specific for fibrolamellar carcinoma.

0 references

Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK.

0 references

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations

0 references

I1171 missense mutation (particularly I1171N) is a common resistance mutation in ALK-positive NSCLC patients who have progressive disease while on alectinib and is sensitive to ceritinib

0 references

Smoothened variants explain the majority of drug resistance in basal cell carcinoma

0 references

CD44 Isoform Status Predicts Response to Treatment with Anti-CD44 Antibody in Cancer Patients

0 references

Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer

0 references

Rapid response to trastuzumab emtansine in a patient with HER2-driven lung cancer.

0 references

Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing.

0 references

Personalized treatment of Sézary syndrome by targeting a novel CTLA4:CD28 fusion.

0 references

TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer

0 references

Ibrutinib in previously treated Waldenström's macroglobulinemia.

0 references

Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies

0 references

Afatinib is especially effective against non-small cell lung cancer carrying an EGFR exon 19 deletion

0 references

Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancer.

0 references

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity

0 references

Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial

0 references

Targeting HER2 aberrations as actionable drivers in lung cancers: phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumors

0 references

TFF3 is a valuable predictive biomarker of endocrine response in metastatic breast cancer

0 references

The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide

0 references

Detection of Crizotinib-Sensitive Lung Adenocarcinomas With MET, ALK, and ROS1 Genomic Alterations via Comprehensive Genomic Profiling

0 references

AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer

0 references

Rociletinib in EGFR-mutated non-small-cell lung cancer

0 references

Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma

0 references

Proteomic Profiling of Paclitaxel Treated Cells Identifies a Novel Mechanism of Drug Resistance Mediated by PDCD4.

0 references

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M.

0 references

Preclinical Test of Dacomitinib, an Irreversible EGFR Inhibitor, Confirms Its Effectiveness for Glioblastoma

0 references

KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine

0 references

Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors

0 references

Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors

0 references

Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping

0 references

Decreased peritherapeutic VEGF expression could be a predictor of responsiveness to first-line FOLFIRI plus bevacizumab in mCRC patients

0 references

Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer

0 references

Integrative clinical genomics of advanced prostate cancer

0 references

FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers

0 references

The FNTB promoter polymorphism rs11623866 as a potential predictive biomarker for lonafarnib treatment of ovarian cancer patients.

0 references

Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma

0 references

WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients

0 references

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

0 references

Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers

0 references

Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.

0 references

Fibroblast Growth Factor Receptor Family Members as Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma: A Systematic Review

0 references

Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib

0 references

Impact of KRAS codon subtypes from a randomised phase II trial of selumetinib plus docetaxel in KRAS mutant advanced non-small-cell lung cancer

0 references

Efficacy of Imatinib in Patients with Platelet-Derived Growth Factor Receptor Alpha-Mutated Gastrointestinal Stromal Tumors

0 references

Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer

0 references

A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer.

0 references

ERCC1 as a Prognostic and Predictive Biomarker for Urothelial Carcinoma of the Bladder following Radical Cystectomy

0 references

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

0 references

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

0 references

Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma

0 references

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma

0 references

Acquired Resistance of EGFR-Mutant Lung Cancer to a T790M-Specific EGFR Inhibitor: Emergence of a Third Mutation (C797S) in the EGFR Tyrosine Kinase Domain

0 references

Elevated Serum Gas6 Is a Novel Prognostic Biomarker in Patients with Oral Squamous Cell Carcinoma

0 references

Promising response of anaplastic lymphoma kinase-positive large B-cell lymphoma to crizotinib salvage treatment: case report and review of literature

0 references

HER2 activating mutations are targets for colorectal cancer treatment

0 references

Optimal adjuvant treatment for patients with HER2-positive breast cancer in 2015.

0 references

Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry

0 references

Whole blood defensin mRNA expression is a predictive biomarker of docetaxel response in castration-resistant prostate cancer

0 references

Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer

0 references

IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma

0 references

Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations

0 references

Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma

0 references

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

0 references

Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma

0 references

Heme oxygenase-1 is a predictive biomarker for therapeutic targeting of advanced clear cell renal cell carcinoma treated with sorafenib or sunitinib

0 references

Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer

0 references

PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups

0 references

A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy

0 references

Prognostic value of different cut-off levels of Ki-67 in breast cancer: a systematic review and meta-analysis of 64,196 patients

0 references

Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors

0 references

Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia

0 references

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

0 references

RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors

0 references

Phase II study of single-agent cetuximab in KRAS G13D mutant metastatic colorectal cancer.

0 references

Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases

0 references

Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors

0 references

Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38.

0 references

Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.

0 references

BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells

0 references

OCT4B1 promotes cell growth, migration and invasion suppressing sensitivity to οxaliplatin in colon cancer

0 references

Afatinib, an irreversible ErbB family blocker, with protracted temozolomide in recurrent glioblastoma: a case report

0 references

LRP1B deletion is associated with poor outcome for glioblastoma patients

0 references

Low EGFR/MET ratio is associated with resistance to EGFR inhibitors in non-small cell lung cancer

0 references

MicroRNA-218 is a prognostic indicator in colorectal cancer and enhances 5-fluorouracil-induced apoptosis by targeting BIRC5.

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The relation of EGFR expression by immunohistochemical staining and clinical response of combination treatment of nimotuzumab and chemotherapy in esophageal squamous cell carcinoma

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Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer

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Response to Idelalisib in a Patient with Stage IV Merkel-Cell Carcinoma

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Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer

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Clinical and molecular response to interferon-α therapy in essential thrombocythemia patients with CALR mutations.

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Analysis of mTOR Gene Aberrations in Melanoma Patients and Evaluation of Their Sensitivity to PI3K-AKT-mTOR Pathway Inhibitors

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Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer

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Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients.

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DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

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In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer

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Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.

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Mutant HRAS as novel target for MEK and mTOR inhibitors

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An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib

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MET gene exon 14 deletion created using the CRISPR/Cas9 system enhances cellular growth and sensitivity to a MET inhibitor.

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The ALK/ROS1 Inhibitor PF-06463922 Overcomes Primary Resistance to Crizotinib in ALK-Driven Neuroblastoma

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HER2 insertion YVMA mutant lung cancer: Long natural history and response to afatinib.

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HRAS G13D, a new mutation implicated in the resistance to anti-EGFR therapies in colorectal cancer, a case report

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Antitumor effects and molecular mechanisms of ponatinib on endometrial cancer cells harboring activating FGFR2 mutations

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Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations.

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Afatinib alone or afatinib plus vinorelbine versus investigator's choice of treatment for HER2-positive breast cancer with progressive brain metastases after trastuzumab, lapatinib, or both (LUX-Breast 3): ...

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Increased expression of MyD88 and association with paclitaxel resistance in breast cancer

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Lung cancer patients with HER2 mutations treated with chemotherapy and HER2-targeted drugs: results from the European EUHER2 cohort

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Elevated expression of RIT1 correlates with poor prognosis in endometrial cancer

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Cetuximab treatment for metastatic colorectal cancer with KRAS p.G13D mutations improves progression-free survival

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Prognostic impact of programmed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor-infiltrating lymphocytes in ovarian high grade serous carcinoma

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Different prognostic impact of STK11 mutations in non-squamous non-small-cell lung cancer.

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Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

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Targeting Fibroblast Growth Factor Receptor (FGFR) with BGJ398 in a Gastric Cancer Model

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TP53 mutational status is predictive of pazopanib response in advanced sarcomas

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Reduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis

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Prognostic value of programmed cell death-ligand 1 expression in patients with non-small-cell lung cancer: evidence from an updated meta-analysis

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Afatinib, an Irreversible EGFR Family Inhibitor, Shows Activity Toward Pancreatic Cancer Cells, Alone and in Combination with Radiotherapy, Independent of KRAS Status

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SMARCA4/BRG1 Is a Novel Prognostic Biomarker Predictive of Cisplatin-Based Chemotherapy Outcomes in Resected Non-Small Cell Lung Cancer

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FGFR1 is an adverse outcome indicator for luminal A breast cancers

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Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade

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Prognostic value of high EZH2 expression in patients with different types of cancer: a systematic review with meta-analysis

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Vandetanib as a potential new treatment for estrogen receptor-negative breast cancers.

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Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.

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Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial

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KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism

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Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With [...]

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NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer

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Osimertinib Responses After Disease Progression in Patients Who Had Been Receiving Rociletinib

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Epidermal Growth Factor Receptor Gene Amplification in Patients with Advanced-stage NSCLC.

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Response to Crizotinib Observed in Lung Adenocarcinoma with MET Copy Number Gain but without a High-Level MET/CEP7 Ratio, MET Overexpression, or Exon 14 Splicing Mutations

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Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

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Osimertinib: First Global Approval

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MET Exon 14 Mutations in Non-Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met Overexpression

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Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.

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Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer

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BRCA1/2 mutations associated with progression-free survival in ovarian cancer patients in the AGO-OVAR 16 study.

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TOPK promotes lung cancer resistance to EGFR tyrosine kinase inhibitors by phosphorylating and activating c-Jun

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TERT mutation in glioma: Frequency, prognosis and risk

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TP53 mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation

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Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage III non-small cell lung cancer patients receiving concurrent chemoradiotherapy

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A novel acquired ALK F1245C mutation confers resistance to crizotinib in ALK-positive NSCLC but is sensitive to ceritinib

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Nimotuzumab enhances temozolomide-induced growth suppression of glioma cells expressing mutant EGFR in vivo

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Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis.

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Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors

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Assessment of Minimal Residual Disease in Standard-Risk AML.

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CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer

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Low thrombospondin 2 expression is predictive of low tumor regression after neoadjuvant chemoradiotherapy in rectal cancer

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Serum Human Epidermal Growth Factor 2 Extracellular Domain as a Predictive Biomarker for Lapatinib Treatment Efficacy in Patients With Advanced Breast Cancer

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Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours.

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Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma

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Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.

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Afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one previous trastuzumab treatment (LUX-Breast 1): an open-label, randomised, phase 3 trial

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Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.

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Complete loss of STAG2 expression is an indicator of good prognosis in patients with bladder cancer

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Combined Epiregulin and Amphiregulin Expression Levels as a Predictive Biomarker for Panitumumab Therapy Benefit or Lack of Benefit in Patients With RAS Wild-Type Advanced Colorectal Cancer

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Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes

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Neratinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (ExteNET): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

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CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

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Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

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The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer

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Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy.

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Downregulation of cytokeratin 18 is associated with paclitaxel‑resistance and tumor aggressiveness in prostate cancer.

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A genetic variation in microRNA target site of ETS2 is associated with clinical outcomes of paclitaxel-cisplatin chemotherapy in non-small cell lung cancer

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High expression of HEF1 predicts a poorer prognosis of hepatocellular carcinoma: A retrospective study

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CIP2A down regulation enhances the sensitivity of pancreatic cancer cells to gemcitabine

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Epiregulin is required for lung tumor promotion in a murine two-stage carcinogenesis model

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Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade

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PSMB8 and PBK as potential gastric cancer subtype-specific biomarkers associated with prognosis

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Prognostic and Predictive Effect of TP53 Mutations in Patients with Non-Small Cell Lung Cancer from Adjuvant Cisplatin-Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis

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Correlation of TP53 and MDM2 genotypes and clinical outcome in platinum-treated head and neck cancer patients with more than 10 years' follow-up

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Clinical activity of ceritinib in ROS1-rearranged non-small cell lung cancer: Bench to bedside report

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Association of Nuclear PIM1 Expression with Lymph Node Metastasis and Poor Prognosis in Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma

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PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis

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MMP2 and MMP9 serum levels are associated with favorable outcome in patients with inflammatory breast cancer treated with bevacizumab-based neoadjuvant chemotherapy in the BEVERLY-2 study.

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Rapid and dramatic response to alectinib in an anaplastic lymphoma kinase rearranged non-small-cell lung cancer patient who is critically ill.

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Nuclear heat shock protein 110 expression is associated with poor prognosis and chemotherapy resistance in gastric cancer

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High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma.

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Biomarkers of evasive resistance predict disease progression in cancer patients treated with antiangiogenic therapies

0 references

Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial

0 references

Activity and safety of ceritinib in patients with ALK-rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial

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Long Term Survival and Continued Complete Response of Vemurafenib in a Metastatic Melanoma Patient with BRAF V600K Mutation

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Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency.

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KDR Mutation as a Novel Predictive Biomarker of Exceptional Response to Regorafenib in Metastatic Colorectal Cancer

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PD-L1 is an independent prognostic predictor in gastric cancer of Western patients

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KRAS G12D Mutation Subtype Is A Prognostic Factor for Advanced Pancreatic Adenocarcinoma

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Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults

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Intracranial Efficacy of Crizotinib Versus Chemotherapy in Patients With Advanced ALK-Positive Non-Small-Cell Lung Cancer: Results From PROFILE 1014.

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The MKK7 p.Glu116Lys Rare Variant Serves as a Predictor for Lung Cancer Risk and Prognosis in Chinese

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An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

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Nanofluidic Digital PCR and Extended Genotyping of RAS and BRAF for Improved Selection of Metastatic Colorectal Cancer Patients for Anti-EGFR Therapies.

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BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination Therapy

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Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice

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Molecular correlates of anemia in primary myelofibrosis: a significant and independent association with U2AF1 mutations

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The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

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Programmed death-ligand 1 overexpression is a prognostic marker for aggressive papillary thyroid cancer and its variants

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Molecular Alterations and Everolimus Efficacy in Human Epidermal Growth Factor Receptor 2-Overexpressing Metastatic Breast Cancers: Combined Exploratory Biomarker Analysis From BOLERO-1 and BOLERO-3.

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Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma.

0 references

PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.

0 references

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial

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RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features

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Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G1 Arrest/S Phase Delay and Inhibition of Apoptosis During Chemotherapy in Bone Marrow

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The AXL receptor tyrosine kinase is associated with adverse prognosis and distant metastasis in esophageal squamous cell carcinoma

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Feasibility of novel PPP1R15A and proposed ANXA11 single nucleotide polymorphisms as predictive markers for bevacizumab regimen in metastatic colorectal cancer

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Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia

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Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients

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Complex karyotypes and KRAS and POT1 mutations impact outcome in CLL after chlorambucil-based chemotherapy or chemoimmunotherapy

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High CDK6 Protects Cells from Fulvestrant-Mediated Apoptosis and is a Predictor of Resistance to Fulvestrant in Estrogen Receptor-Positive Metastatic Breast Cancer

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Genomic Classification and Prognosis in Acute Myeloid Leukemia

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Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.

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Heterogeneity of resistance mutations detectable by next-generation sequencing in TKI-treated lung adenocarcinoma

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Comprehensive mutation profiling of mucinous gastric carcinoma

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MET-Driven Resistance to Dual EGFR and BRAF Blockade May Be Overcome by Switching from EGFR to MET Inhibition in BRAF-Mutated Colorectal Cancer.

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Colorectal Cancer with BRAF D594G Mutation Is Not Associated with Microsatellite Instability or Poor Prognosis

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Genetic Variants in the p14ARF/MDM2/TP53 Pathway Are Associated with the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated with Radical Resection

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Vemurafenib in patients with BRAF(V600E)-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial

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Toward the molecular dissection of peritoneal pseudomyxoma.

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Clinical Improvement with JAK2 Inhibition in Chuvash Polycythemia

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The PML/RAR alpha fusion gene in the diagnosis and monitoring of acute promyelocytic leukemia.

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p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

0 references

Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway

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p53 mutation and locoregional treatment failure in head and neck squamous cell carcinoma

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The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: ...

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Wikidata property

CIViC variant ID

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https://www.wikidata.org/wiki/Wikidata:Property_proposal/CIViC_gene_ID

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