(Q27697939)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

author name string

Subramaniapillai Kolappan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

David L Shen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Renee Mosi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Jianyu Sun

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Ernest J McEachern

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

publication date

23 January 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

Acta Crystallographica Section D: Biological Crystallography

29 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

issue

Pt 2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

page(s)

185-195

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

Refined crystal structure of dogfish M4 apo-lactate dehydrogenase

29 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Biological roles of nontypeable Haemophilus influenzae type IV pilus proteins encoded by the pil and com operons

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

MolProbity: all-atom structure validation for macromolecular crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Coot: model-building tools for molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Impairment of aerobic glycolysis by inhibitors of lactic dehydrogenase hinders the growth of human hepatocellular carcinoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Web-Ice: integrated data collection and analysis for macromolecular crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Targeting glucose metabolism for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

A deliberate approach to screening for initial crystallization conditions of biological macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Solvent content of protein crystals

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

REFMAC5 for the refinement of macromolecular crystal structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Modeling of isotope effects on binding oxamate to lactic dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Targeting cancer metabolism: a therapeutic window opens

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

On the Origin of Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Overview of the CCP4 suite and current developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1107%2FS1399004714024791

10.1107/S1399004714024791

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25664730%20AND%20SRC:MED&resulttype=core&format=json