(Q27682496)

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Xuan Cao

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Xing Li

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Chengjun Li

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Courtney Voss

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Sachdev S Sidhu

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Shawn S C Li

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

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publication date

25 September 2012

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243

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page(s)

ra68

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cites work

1 reference

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The SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotes

21 April 2017

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Loops govern SH2 domain specificity by controlling access to binding pockets

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Defining the specificity space of the human SRC homology 2 domain

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

A quantitative protein interaction network for the ErbB receptors using protein microarrays

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

The protein kinase complement of the human genome

21 April 2017

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https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

The language of SH2 domain interactions defines phosphotyrosine-mediated signal transduction

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Optimization of specificity in a cellular protein interaction network by negative selection

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Version 1.2 of the Crystallography and NMR system

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Three-dimensional structure of the tyrosine kinase c-Src

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Simplified screening for the detection of soluble fusion constructs expressed in E. coli using a modular set of vectors

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Molecular replacement with MOLREP

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Requirements for Specific Binding of Low Affinity Inhibitor Fragments to the SH2 Domain ofpp60Src Are Identical to Those for High Affinity Binding of Full Length Inhibitors

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

REFMAC5 for the refinement of macromolecular crystal structures

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Features and development of Coot

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Overview of the CCP4 suite and current developments

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

WebLogo: A Sequence Logo Generator

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.2003021

An introduction to data reduction: space-group determination, scaling and intensity statistics

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Reading protein modifications with interaction domains

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Cell signaling in space and time: where proteins come together and when they're apart

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

SH2 domains: role, structure and implications for molecular medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Profiling the global tyrosine phosphorylation state by Src homology 2 domain binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Recognition and specificity in protein tyrosine kinase-mediated signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Defining SH2 domain and PTP specificity by screening combinatorial peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

PDZ domain binding selectivity is optimized across the mouse proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

A Single Point Mutation Switches the Specificity of Group III Src Homology (SH) 2 Domains to That of Group I SH2 Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Phage display for selection of novel binding peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

The ShcA adaptor protein is a critical regulator of breast cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

ErbB family receptor inhibitors as therapeutic agents in breast cancer: current status and future clinical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

New driver mutations in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

ErbB receptors and signaling pathways in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

The molecular and genetic basis of neurological tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Evolving specificity from variability for protein interaction domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Positive selection of tyrosine loss in metazoan evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Host cell interactome of tyrosine-phosphorylated bacterial proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Designing customized cell signalling circuits

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Engineering synthetic signaling proteins with ultrasensitive input/output control

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Kinase mutations in human disease: interpreting genotype-phenotype relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Studying Binding Specificities of Peptide Recognition Modules by High-Throughput Phage Display Selections

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Expression and purification of soluble His(6)-tagged TEV protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

LAFIRE: software for automating the refinement process of protein-structure analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

NQ-Flipper: recognition and correction of erroneous asparagine and glutamine side-chain rotamers in protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

PROMALS3D web server for accurate multiple protein sequence and structure alignments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021

Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003021