(Q27022248)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

The lysosome: from waste bag to potential therapeutic target (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Hanna Appelqvist

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Katarina Kågedal

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Karin Öllinger

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

language of work or name

1 reference

1 August 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

Journal of Molecular Cell Biology

6 March 2020

published in

2 references

PubMed

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

page(s)

214-226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

Regulated secretion of conventional lysosomes

6 March 2020

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Tissue fractionation studies. 5. The association of acid phosphatase with a special class of cytoplasmic granules in rat liver

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Attenuation of the Lysosomal Death Pathway by Lysosomal Cholesterol Accumulation

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Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases

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Lysosomal disorders: from storage to cellular damage

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Pathophysiology of neuropathic lysosomal storage disorders

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Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease?

21 January 2018

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Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice.

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Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis

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UVA/B-induced apoptosis in human melanocytes involves translocation of cathepsins and Bcl-2 family members

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Hsp70 protects against UVB induced apoptosis by preventing release of cathepsins and cytochrome c in human melanocytes

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Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization.

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Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion

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Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells.

21 January 2018

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A receptor-mediated pathway for cholesterol homeostasis

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Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes

21 January 2018

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Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak

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Rab7: a key to lysosome biogenesis

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Programmed cell death (PCD). Apoptosis, autophagic PCD, or others?

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Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models

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What is the concentration of calcium ions in the endoplasmic reticulum?

21 January 2018

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

21 January 2018

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Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy

21 January 2018

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Aryl hydrocarbon receptor modulation of tumor necrosis factor-alpha-induced apoptosis and lysosomal disruption in a hepatoma model that is caspase-8-independent

21 January 2018

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Cyclodextrin Induces Calcium-Dependent Lysosomal Exocytosis

21 January 2018

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Localization of cysteine protease, cathepsin S, to the surface of vascular smooth muscle cells by association with integrin alphanubeta3

21 January 2018

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Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications

21 January 2018

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Autophagy deregulation in neurodegenerative diseases – recent advances and future perspectives

21 January 2018

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NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

21 January 2018

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Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins

21 January 2018

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Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.

21 January 2018

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Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

21 January 2018

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Plasma membrane signaling induced by ionizing radiation

21 January 2018

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A receptor for the selective uptake and degradation of proteins by lysosomes

21 January 2018

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The recovery of resting potential and input resistance in sheep heart injured by knife or laser

21 January 2018

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Peptide sequences that target cytosolic proteins for lysosomal proteolysis

21 January 2018

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Depletion of TSG101 forms a mammalian "Class E" compartment: a multicisternal early endosome with multiple sorting defects.

21 January 2018

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Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues

21 January 2018

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

21 January 2018

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Amino acids and mTORC1: from lysosomes to disease

21 January 2018

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Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease

21 January 2018

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Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis

21 January 2018

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The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis

21 January 2018

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At the acidic edge: emerging functions for lysosomal membrane proteins

21 January 2018

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Sensitization to the lysosomal cell death pathway upon immortalization and transformation

21 January 2018

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Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.

21 January 2018

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Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

21 January 2018

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Distinct roles for cysteine cathepsin genes in multistage tumorigenesis

21 January 2018

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Bacterial pore-forming toxins: the (w)hole story?

21 January 2018

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Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase

21 January 2018

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Combating apoptosis and multidrug resistant cancers by targeting lysosomes.

21 January 2018

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Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

21 January 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

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Control of autophagy as a therapy for neurodegenerative disease

21 January 2018

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Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation

21 January 2018

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Vectorial budding of vesicles by asymmetrical enzymatic formation of ceramide in giant liposomes

21 January 2018

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Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1).

21 January 2018

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Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics

21 January 2018

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21 January 2018

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Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis

21 January 2018

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MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis

21 January 2018

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Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells

21 January 2018

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Regulation of apoptosis-associated lysosomal membrane permeabilization

21 January 2018

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Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice

21 January 2018

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Lysosomal membrane permeabilization during apoptosis--involvement of Bax?

21 January 2018

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Cancer-associated lysosomal changes: friends or foes?

21 January 2018

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Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis

21 January 2018

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Chaperone-mediated autophagy: a unique way to enter the lysosome world

21 January 2018

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Lysosomal involvement in cell death and cancer.

21 January 2018

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Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.

21 January 2018

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Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.

21 January 2018

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A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

21 January 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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Lysosomal positioning coordinates cellular nutrient responses.

21 January 2018

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Stat3 controls lysosomal-mediated cell death in vivo

21 January 2018

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Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

21 January 2018

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Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.

21 January 2018

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Conformational switching in an aspartic proteinase

21 January 2018

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

21 January 2018

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Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

21 January 2018

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Autophagy in the Pathogenesis of Disease

21 January 2018

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Increased expression and translocation of lysosomal cathepsins contribute to macrophage apoptosis in atherogenesis

21 January 2018

1 reference

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Uptake of Oxidized LDL by Macrophages Results in Partial Lysosomal Enzyme Inactivation and Relocation

21 January 2018

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Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis

21 January 2018

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Microautophagy: lesser-known self-eating

21 January 2018

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Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells

21 January 2018

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Increased serum cathepsin S in patients with atherosclerosis and diabetes

21 January 2018

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Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion

21 January 2018

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Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases

21 January 2018

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Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Proteomics of the lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation

21 January 2018

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Cathepsin cysteine proteases in cardiovascular disease.

21 January 2018

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The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function

21 January 2018

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Synaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblasts

21 January 2018

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Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

21 January 2018

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Transcriptional activation of lysosomal exocytosis promotes cellular clearance

21 January 2018

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Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.

21 January 2018

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Lysosomal acidification mechanisms

21 January 2018

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Mobilization of lysosomal calcium regulates the externalization of phosphatidylserine during apoptosis

21 January 2018

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Autophagy: renovation of cells and tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

21 January 2018

1 reference

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EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif

21 January 2018

1 reference

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The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo

21 January 2018

1 reference

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Cytosolic acidification and lysosomal alkalinization during TNF-alpha induced apoptosis in U937 cells.

21 January 2018

1 reference

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Intrinsic differences in cisplatin sensitivity of head and neck cancer cell lines: Correlation to lysosomal pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Autophagy failure in Alzheimer's disease—locating the primary defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Neurodegenerative lysosomal disorders: a continuum from development to late age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Identification and characterization of a proton pump on lysosomes by fluorescein-isothiocyanate-dextran fluorescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Cysteine cathepsin proteases as pharmacological targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Lysosomal storage disease: revealing lysosomal function and physiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Studies of pH regulation by Btn1p, the yeast homolog of human Cln3p

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Mitochondrial degradation in acetic acid-induced yeast apoptosis: the role of Pep4 and the ADP/ATP carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Prevention of oxidant-induced cell death by lysosomotropic iron chelators

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction

21 January 2018

1 reference

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The birth prevalence of lysosomal storage disorders in the Czech Republic: comparison with data in different populations

21 January 2018

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M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues

21 January 2018

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Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Destabilizing role of cathepsin S in murine atherosclerotic plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Comprehensive search for cysteine cathepsins in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Lysosomal membrane proteins: life between acid and neutral conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Use of acid sphingomyelinase for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

The catalytically inactive precursor of cathepsin D induces apoptosis in human fibroblasts and HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Clarifying lysosomal storage diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

TFEB links autophagy to lysosomal biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Cystatin C deficiency in human atherosclerosis and aortic aneurysms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Mycobacteria and the intraphagosomal environment: take it with a pinch of salt(s)!

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Cell membrane resealing by a vesicular mechanism similar to neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Endocytosis and the recycling of plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Lysosomes as "suicide bags" in cell death: myth or reality?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Treatment options for lysosomal storage disorders: developing insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Niemann-Pick disease type C

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Redox-dependent translocation of p53 to mitochondria or nucleus in human melanocytes after UVA- and UVB-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

The endosome-lysosome pathway and information generation in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Increased urine concentration of subunit c of mitochondrial ATP synthase in neuronal ceroid lipofuscinoses patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Multivesicular bodies: co-ordinated progression to maturity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Transient brain ischaemia provokes Ca2+, PIP2 and calpain responses prior to delayed neuronal death in monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Lysosomal destabilization in p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Regulated ATP release from astrocytes through lysosome exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

Membrane trafficking in osteoblasts and osteoclasts: new avenues for understanding and treating skeletal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJT022

21 January 2018

Identifiers

DOI

10.1093/JMCB/MJT022

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23918283%20AND%20SRC:MED&resulttype=core&format=json