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English
Factor XI as a target for antithrombotic therapy
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1 reference
stated in
PubMed
title
Factor XI as a target for antithrombotic therapy
(English)
1 reference
stated in
PubMed
author name string
Charles E. Bane
series ordinal
1
1 reference
stated in
Crossref
David Gailani
series ordinal
2
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stated in
Crossref
language of work or name
English
1 reference
stated in
PubMed
publication date
September 2014
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stated in
PubMed
published in
Drug Discovery Today
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stated in
PubMed
volume
19
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stated in
PubMed
issue
9
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stated in
PubMed
page(s)
1454-8
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stated in
PubMed
cites work
Defective thrombus formation in mice lacking coagulation factor XII
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
21 March 2017
Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
21 March 2017
Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
21 March 2017
Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
21 March 2017
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
21 March 2017
Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
21 March 2017
Factor XII inhibition reduces thrombus formation in a primate thrombosis model
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Evidence for factor IX-independent roles for factor XIa in blood coagulation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Factor XI anion-binding sites are required for productive interactions with polyphosphate.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Novel oral anticoagulants: a review of new agents.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Congenital factor XI deficiency: an update.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
A sequential mechanism for exosite-mediated factor IX activation by factor XIa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Tissue factor pathway inhibitor: structure-function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Factor XI: hemostasis, thrombosis, and antithrombosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Activation of factor XI by products of prothrombin activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Coagulation factor XI as a novel target for antithrombotic treatment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Structure and function of factor XI
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 September 2017
Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
31 May 2018
High levels of factor IX increase the risk of venous thrombosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
31 May 2018
Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 November 2018
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 November 2018
Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: Opposite and synergistic effects of factors XI and XII.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 November 2018
Variable bleeding manifestations characterize different types of surgery in patients with severe factor XI deficiency enabling parsimonious use of replacement therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 November 2018
Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167190
retrieved
28 November 2018
High levels of coagulation factor XI as a risk factor for venous thrombosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24886766
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Elevated factor XI activity levels are associated with an increased odds ratio for cerebrovascular events
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24886766
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24886766
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Reduced incidence of ischemic stroke in patients with severe factor XI deficiency
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24886766
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24886766
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24886766
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.DRUDIS.2014.05.018
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2437848
OpenCitations bibliographic resource ID
2437848
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2437848
PMC publication ID
4167190
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2437848
PubMed publication ID
24886766
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2437848
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