(Q26752535)

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Pyruvate Kinase M2: A Potential Target for Regulating Inflammation

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Europe PubMed Central

Pyruvate Kinase M2: A Potential Target for Regulating Inflammation (English)

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Jose C Alves-Filho

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Eva M Pålsson-McDermott

2

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2016

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Frontiers in Immunology

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7

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145

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No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Identification of small molecule inhibitors of pyruvate kinase M2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Isolation and characterization of the human pyruvate kinase M gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Pyruvate kinase: Function, regulation and role in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Serine and glycine metabolism in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Pyruvate kinase M2 at a glance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

Homeostasis, inflammation, and disease susceptibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

7 April 2017

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Lack of Evidence for PKM2 Protein Kinase Activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Pyruvate kinase M2 and cancer: an updated assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Activation of Akt protects cancer cells from growth inhibition induced by PKM2 knockdown

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Control of glioma cell death and differentiation by PKM2-Oct4 interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

PKM2 regulates chromosome segregation and mitosis progression of tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

The Warburg effect then and now: from cancer to inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Nuclear PKM2 regulates the Warburg effect.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Proteomic analysis of synovial fibroblast-like synoviocytes from rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Emerging roles of PKM2 in cell metabolism and cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Inhibition of human brain pyruvate kinase and hexokinase by phenylalanine and phenylpyruvate: possible relevance to phenylketonuric brain damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Alternative splicing of the pyruvate kinase M gene in a minigene system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 September 2017

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

31 May 2018

Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

31 May 2018

An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1,6-bisphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

31 May 2018

Eukaryotic initiation factor 6 modulates myofibroblast differentiation at transforming growth factor-β1 transcription level via H2A.Z occupancy and Sp1 recruitment.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00145

21 January 2018

miR-122 inhibits cancer cell malignancy by targeting PKM2 in gallbladder carcinoma

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00145

21 January 2018

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00145

21 January 2018

Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00145

21 January 2018

The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00145

21 January 2018

Glutamine enema regulates colonic ubiquitinated proteins but not proteasome activities during TNBS-induced colitis leading to increased mitochondrial activity.

1 reference

https://api.crossref.org/works/10.3389%2FFIMMU.2016.00145

21 January 2018

Structural and kinetic differences between the M2 type pyruvate kinases from lung and various tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838608

28 November 2018

Subunit Structure of Rabbit Muscle Pyruvate Kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/27148264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate kinase M2 regulates apoptosis of intestinal epithelial cells in Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27148264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fecal M2-PK in children with Crohn's disease: a preliminary report

1 reference

https://pubmed.ncbi.nlm.nih.gov/27148264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate kinase: modulation by L-phenylalanine and L-alanine

1 reference

https://pubmed.ncbi.nlm.nih.gov/27148264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fecal M2-pyruvate kinase (M2-PK): a novel marker of intestinal inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27148264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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