(Q24633063)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

0 references

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Michelle Pacholec

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

John E Bleasdale

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Boris Chrunyk

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

David Cunningham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Declan Flynn

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Robert S Garofalo

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

David Griffith

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Matt Griffor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Pat Loulakis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Brandon Pabst

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Xiayang Qiu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Venkataraman Thanabal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Alison Varghese

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Jessica Ward

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Jane Withka

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Kay Ahn

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

language of work or name

English

0 references

publication date

8 January 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

16 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

volume

285

1 reference

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16 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

page(s)

8340-8351

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

16 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Negative control of p53 by Sir2alpha promotes cell survival under stress

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Resveratrol improves health and survival of mice on a high-calorie diet

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Resveratrol is not a direct activator of SIRT1 enzyme activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Mechanism of human SIRT1 activation by resveratrol

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Substrate-specific activation of sirtuins by resveratrol

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Calorie restriction increases muscle mitochondrial biogenesis in healthy humans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Central administration of resveratrol improves diet-induced diabetes.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

SIRT1 and insulin resistance

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Mechanisms and molecular probes of sirtuins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

SirT1 gain of function increases energy efficiency and prevents diabetes in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Sirtuins: a conserved key unlocking AceCS activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Screening for positive allosteric modulators of biological targets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

The biochemistry of sirtuins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

The molecular biology of the SIR proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Kinetic Properties and Structural Characterization of Highly Purified Acetyl-CoA Synthetase from Bovine Heart and Tissue Distribution of the Enzyme in Rat Tissues

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Purification of recombinant p53 from Sf9 insect cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

Insulin resistance as a predictor of age-related diseases

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832984

28 November 2018

Identifiers

DOI

10.1074/JBC.M109.088682

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

20061378

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20061378%20AND%20SRC:MED&resulttype=core&format=json