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Links between metabolism and cancer

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Links between metabolism and cancer (English)

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Chi V Dang

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1 May 2012

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Genes & Development

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26

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9

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877-90

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Full-length human glutaminase in complex with an allosteric inhibitor

1 reference

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

1 reference

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7 April 2017

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

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7 April 2017

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

1 reference

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7 April 2017

Regulation of cellular metabolism by protein lysine acetylation

1 reference

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7 April 2017

Identification of small molecule inhibitors of pyruvate kinase M2

1 reference

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7 April 2017

HIF-1: upstream and downstream of cancer metabolism

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7 April 2017

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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7 April 2017

Caloric restriction delays disease onset and mortality in rhesus monkeys

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Tumours with PI3K activation are resistant to dietary restriction

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IDH1 and IDH2 mutations in gliomas

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An integrated genomic analysis of human glioblastoma multiforme

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Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

1 reference

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7 April 2017

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

1 reference

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Global mapping of c-Myc binding sites and target gene networks in human B cells

1 reference

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

1 reference

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7 April 2017

Hypoxia-inducible factors in physiology and medicine

1 reference

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7 April 2017

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

1 reference

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7 April 2017

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

1 reference

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7 April 2017

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

1 reference

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7 April 2017

Mechanisms of mitophagy

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7 April 2017

A role for E2F activities in determining the fate of Myc-induced lymphomagenesis

1 reference

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7 April 2017

On the Origin of Cancer Cells

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7 April 2017

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

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Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

1 reference

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7 April 2017

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

1 reference

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Molecular mechanisms of cancer development in obesity

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7 April 2017

Regulation of cancer cell metabolism

1 reference

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7 April 2017

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

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7 April 2017

Cancer cell metabolism: Warburg and beyond

1 reference

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p53 regulates mitochondrial respiration

1 reference

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7 April 2017

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

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7 April 2017

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

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Peto's Paradox: evolution's prescription for cancer prevention

1 reference

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1 reference

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7 April 2017

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

1 reference

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7 April 2017

Autophagy and aging

1 reference

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7 April 2017

Signal transduction by reactive oxygen species

1 reference

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7 April 2017

Otto Warburg's contributions to current concepts of cancer metabolism

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7 April 2017

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

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Circadian integration of metabolism and energetics

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7 April 2017

Autophagy and Metabolism

1 reference

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7 April 2017

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

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7 April 2017

p53 and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

7 April 2017

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

1 reference

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7 April 2017

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

7 April 2017

The impact of O2 availability on human cancer

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7 April 2017

Akt stimulates aerobic glycolysis in cancer cells

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7 April 2017

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

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Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.

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The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

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27 September 2017

Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis

1 reference

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27 September 2017

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

1 reference

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27 September 2017

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

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1 reference

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27 September 2017

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

1 reference

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27 September 2017

p53: exercise capacity and metabolism

1 reference

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27 September 2017

Metformin and cancer therapy.

1 reference

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27 September 2017

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

1 reference

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27 September 2017

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

1 reference

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27 September 2017

Metabolic cycling without cell division cycling in respiring yeast

1 reference

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27 September 2017

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation

1 reference

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27 September 2017

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene

1 reference

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27 September 2017

Metabolic flux and the regulation of mammalian cell growth

1 reference

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27 September 2017

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27 September 2017

Targeting cancer metabolism: a therapeutic window opens

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27 September 2017

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis

1 reference

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27 September 2017

Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors

1 reference

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27 September 2017

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms

1 reference

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27 September 2017

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

1 reference

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27 September 2017

The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine

1 reference

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27 September 2017

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors

1 reference

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27 September 2017

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

An extended Myc network contributes to glucose homeostasis in cancer and diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Autophagy in the cellular energetic balance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Principles and current strategies for targeting autophagy for cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Yeast cells can access distinct quiescent states

1 reference

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27 September 2017

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Hypoxia and energetic tumour metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha

1 reference

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27 September 2017

Regulation of intermediary metabolism by protein acetylation

1 reference

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27 September 2017

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

1 reference

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27 September 2017

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

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27 September 2017

Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate

1 reference

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27 September 2017

MYC as a regulator of ribosome biogenesis and protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

1 reference

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27 September 2017

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

1 reference

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27 September 2017

Rethinking the Warburg effect with Myc micromanaging glutamine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

1 reference

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27 September 2017

Using a functional enzyme model to understand the chemistry behind hydrogen sulfide induced hibernation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Metabolism and cancer: the circadian clock connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Dynamic FoxO transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

The c-Myc target gene network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Activation by c-Myc of transcription by RNA polymerases I, II and III.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Night work and risk of breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Akt-dependent transformation: there is more to growth than just surviving

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Clues to the functions of mammalian sleep

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Annual lipid cycles in hibernators: integration of physiology and behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

mtDNA mutations increase tumorigenicity in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Common scale-invariant patterns of sleep-wake transitions across mammalian species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

The key role of anaplerosis and cataplerosis for citric acid cycle function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Ras enhances Myc protein stability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Somatic mutations of the mitochondrial genome in human colorectal tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

27 September 2017

13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

30 May 2018

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

30 May 2018

Connecting threads: epigenetics and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

28 November 2018

Case-control study of shift-work and breast cancer risk in Danish nurses: impact of shift systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

28 November 2018

Why don't all whales have cancer? A novel hypothesis resolving Peto's paradox.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

28 November 2018

Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3347786

28 November 2018

Myc requires distinct E2F activities to induce S phase and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22549953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The energetics of mammalian cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/22549953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-myc transactivates the ornithine decarboxylase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22549953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1101/GAD.189365.112

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

Sitelinks

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