(Q24650163)

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Tubulin-interactive natural products as anticancer agents

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Europe PubMed Central

Tubulin-interactive natural products as anticancer agents (English)

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organic chemistry

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natural product

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based on heuristic

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David G.I. Kingston

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David G I Kingston

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publication date

27 March 2009

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Journal of Natural Products

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72

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3

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507-15

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28 September 2017

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28 September 2017

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28 September 2017

Targeting the microtubules in breast cancer beyond taxanes: the epothilones

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28 September 2017

Oral vinorelbine: role in the management of metastatic breast cancer

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28 September 2017

Vascular disrupting agents in clinical development

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28 September 2017

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28 September 2017

NK105, a paclitaxel-incorporating micellar nanoparticle, is a more potent radiosensitising agent compared to free paclitaxel

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

EPO906 (epothilone B): a promising novel microtubule stabilizer

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28 September 2017

Nonlinear accumulation in the brain of the new taxoid TXD258 following saturation of P-glycoprotein at the blood-brain barrier in mice and rats.

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28 September 2017

Docetaxel in non-small cell lung cancer: a review

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28 September 2017

Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.

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28 September 2017

Epothilone B and its analogs - a new family of anticancer agents

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28 September 2017

Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry

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28 September 2017

Docetaxel: an update of its use in advanced breast cancer

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28 September 2017

Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.

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28 September 2017

Antineoplastic agents 389. New syntheses of the combretastatin A-4 prodrug.

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

The role of vindesine in oncology--recommendations after 10 years' experience.

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28 September 2017

The comparative clinical pharmacology of vincristine and vindesine: does vindesine offer any advantage in clinical use?

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28 September 2017

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

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28 September 2017

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

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28 September 2017

Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum

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28 September 2017

Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp.

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28 September 2017

Phase II Trial of Taxol, an Active Drug in the Treatment of Metastatic Breast Cancer

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28 September 2017

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

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28 September 2017

Promotion of microtubule assembly in vitro by taxol

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28 September 2017

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30 May 2018

3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin

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30 May 2018

Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin

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30 May 2018

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.

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30 May 2018

Interaction of rhizoxin with bovine brain tubulin

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30 May 2018

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites

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30 May 2018

Epothilones and new analogues of the microtubule modulators in taxane-resistant disease

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28 November 2018

Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development.

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28 November 2018

Natural products as drug leads: an old process or the new hope for drug discovery?

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28 November 2018

Chemistry. The renaissance of natural products as drug candidates

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28 November 2018

New microtubule stabilizers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

Drugs from nature. The biology of taxane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

Significance of docetaxel in the chemotherapy of hormone-refractory prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

Phase I and pharmacokinetic trial of the novel taxane BMS-184476 administered as a 1-hour intravenous infusion in combination with cisplatin every 21 days

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

Total synthesis of the microtubule stabilizing antitumor agent laulimalide and some nonnatural analogues: the power of Sharpless' asymmetric epoxidation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

Vascular-targeting activity of ZD6126, a novel tubulin-binding agent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

Phase I and pharmacokinetic study of anhydrovinblastine every 3 weeks in patients with refractory solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

Total synthesis of microtubule-stabilizing agent (-)-laulimalide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

Localization of the vinblastine-binding site on beta-tubulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765517

28 November 2018

EndoTAG-1. MediGene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DHA-paclitaxel (Taxoprexin) as first-line treatment in patients with stage IIIB or IV non-small cell lung cancer: report of a phase II open-label multicenter trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and antitumor activities of amino acid prodrugs of amino-combretastatins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total synthesis of the microtubule-stabilizing agent (-)-laulimalide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical pharmacokinetics and oral bioavailability of BMS-310705, a novel epothilone B analog

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on macrocyclic lactone antibiotics. VII Structure of a phytotoxin "rhizoxin" produced by Rhizopus chinensis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current status of research on the alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Marine Animal Biosynthetic Constituents For Cancer Chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sagopilone (ZK-EPO): from a natural product to a fully synthetic clinical development candidate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic peptides hemiasterlin, hemiasterlin A and hemiasterlin B induce mitotic arrest and abnormal spindle formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New taxanes in development

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of chance observations in chemotherapy: Vinca rosea

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initial studies on the cytotoxic action of maytansine, a novel ansa macrolide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of the taxane BMS-188797 in combination with carboplatin administered every 3 weeks in patients with solid malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenously on days 1, 3, and 5 every 3 weeks in patients with advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/19125622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Halichondrins - antitumor polyether macrolides from a marine sponge

1 reference

20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC198658050701

Identifiers

10.1021/NP800568J

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