(Q24645752)

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David W Borhani

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Morten Ø Jensen

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Stefano Piana

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David E Shaw

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

24 March 2009

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published in

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volume

106

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issue

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page(s)

4689-94

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cites work

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

7 April 2017

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Crystal structure of opsin in its G-protein-interacting conformation

7 April 2017

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Structure of a beta1-adrenergic G-protein-coupled receptor

7 April 2017

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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

7 April 2017

1 reference

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

7 April 2017

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Crystal structure of rhodopsin: A G protein-coupled receptor

7 April 2017

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

7 April 2017

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VMD: visual molecular dynamics

7 April 2017

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

7 April 2017

1 reference

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Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

7 April 2017

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Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery.

7 April 2017

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Atomistic insights into rhodopsin activation from a dynamic model

27 September 2017

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Internal hydration increases during activation of the G-protein-coupled receptor rhodopsin

27 September 2017

1 reference

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High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

27 September 2017

1 reference

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Conformational complexity of G-protein-coupled receptors

27 September 2017

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The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

27 September 2017

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Latest development in drug discovery on G protein-coupled receptors

27 September 2017

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Sugar binding and protein conformational changes in lactose permease

27 September 2017

1 reference

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Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

27 September 2017

1 reference

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The midpoint method for parallelization of particle simulations

27 September 2017

1 reference

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Dynamic behavior of fully solvated beta2-adrenergic receptor, embedded in the membrane with bound agonist or antagonist.

27 September 2017

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Structure of bovine rhodopsin in a trigonal crystal form.

27 September 2017

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Molecular dynamics investigation of primary photoinduced events in the activation of rhodopsin

27 September 2017

1 reference

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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

The superfamily of heptahelical receptors

27 September 2017

1 reference

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Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

27 September 2017

1 reference

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Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

27 September 2017

1 reference

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Mutagenesis of the beta2-Adrenergic Receptor: How Structure Elucidates Function

27 September 2017

1 reference

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Structural biology: A moving story of receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

Insights into signaling from the β2-adrenergic receptor structure

28 November 2018

1 reference

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Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

Biochemistry. Signaling across the cell membrane

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

G protein-coupled receptors show unusual patterns of intrinsic unfolding

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

A molecular spring for vision.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

Electrostatic properties of membrane lipids coupled to metarhodopsin II formation in visual transduction

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650503

A crystal clear view of the beta2-adrenergic receptor

28 November 2018

1 reference

12 December 2020

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

1 reference

12 December 2020

A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7

1 reference

12 December 2020

Potassium and sodium binding to the outer mouth of the K+ channel

1 reference

12 December 2020

Retinal counterion switch mechanism in vision evaluated by molecular simulations

1 reference

12 December 2020

The hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiols

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0811065106

1 reference

ADS bibcode

2009PNAS..106.4689D

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1 reference

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PubMed publication ID

19258456

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