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Neuroprotection for ischemic stroke: past, present and future

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Europe PubMed Central

Neuroprotection for ischemic stroke: past, present and future (English)

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Myron D Ginsberg

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September 2008

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Neuropharmacology

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55

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363-89

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Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites

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On the Analysis and Interpretation of Outcome Measures in Stroke Clinical Trials: Lessons From the SAINT I Study of NXY-059 for Acute Ischemic Stroke

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7 April 2017

NXY-059 for acute ischemic stroke

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7 April 2017

Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors

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7 April 2017

Mitochondrial permeability transition in acute neurodegeneration

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7 April 2017

Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

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7 April 2017

Mitochondrial participation in ischemic and traumatic neural cell death

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7 April 2017

Ebselen: prospective therapy for cerebral ischaemia

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7 April 2017

Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group

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7 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

CDP-choline: pharmacological and clinical review

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7 April 2017

1,026 experimental treatments in acute stroke

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7 April 2017

Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia

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7 April 2017

Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest

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7 April 2017

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials

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7 April 2017

Tissue plasminogen activator for acute ischemic stroke

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7 April 2017

Albumin therapy improves local vascular dynamics in a rat model of primary microvascular thrombosis: a two-photon laser-scanning microscopy study

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27 September 2017

Pathologically activated therapeutics for neuroprotection

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27 September 2017

New insights into the roles of metalloproteinases in neurodegeneration and neuroprotection

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27 September 2017

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke

1 reference

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27 September 2017

Life after cerovive: a personal perspective on ischemic neuroprotection in the post-NXY-059 era.

1 reference

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27 September 2017

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials

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27 September 2017

A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Regeneration and plasticity in the brain and spinal cord

1 reference

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27 September 2017

Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke

1 reference

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27 September 2017

Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

1 reference

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27 September 2017

Induced hypothermia for acute stroke

1 reference

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27 September 2017

Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Molecular targets in cerebral ischemia for developing novel therapeutics

1 reference

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27 September 2017

Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The inflammatory response in stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Acid sensing ion channels--novel therapeutic targets for ischemic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Equipment review: cooling catheters to induce therapeutic hypothermia?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Signalling pathways mediating inflammatory responses in brain ischaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Mechanisms of neuroprotection during ischemic preconditioning: lessons from anoxic tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Growth factors and stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Is magnesium neuroprotective following global and focal cerebral ischaemia? A review of published studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Cerebral preconditioning and ischaemic tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Hypothermic neuroprotection.

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27 September 2017

Bench to bedside: the quest for quality in experimental stroke research

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27 September 2017

Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement

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27 September 2017

Physiology and pathophysiology of Na+/H+ exchange and Na+ -K+ -2Cl- cotransport in the heart, brain, and blood.

1 reference

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27 September 2017

Dopamine in neurotoxicity and neuroprotection: what do D2 receptors have to do with it?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Estrogens and experimental ischemic stroke: a systematic review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Matrix metalloproteinases and diseases of the central nervous system with a special emphasis on ischemic brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Therapeutic hypothermia: from lab to NICU.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Endoplasmic reticulum dysfunction in brain pathology: critical role of protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Physiology and clinical relevance of induced hypothermia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Radiant Medical Reprieve Endovascular Temperature Therapy System

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27 September 2017

Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy

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27 September 2017

Role of reactive oxygen species and protein kinase C in ischemic tolerance in the brain

1 reference

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27 September 2017

Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair

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27 September 2017

Lipid signaling in neural plasticity, brain repair, and neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Piracetam: a review of pharmacological properties and clinical uses.

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27 September 2017

Adult neurogenesis and the ischemic forebrain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Matrix metalloproteinases and free radicals in cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Role of glial cells in cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Failure and function of intracellular pH regulation in acute hypoxic-ischemic injury of astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Potassium homeostasis in the ischemic brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Dose finding study of intravenous magnesium sulphate in transient focal cerebral ischemia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Apoptosis in cerebral ischemia: executional and regulatory signaling mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuroprotection in experimental stroke with targeted neurotrophins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Cell therapy for stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Clinical trials for cytoprotection in stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuroprotection for ischemic stroke: two decades of success and failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Clinical trial of a novel surface cooling system for fever control in neurocritical care patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The pharmacology of chlormethiazole: a potential neuroprotective agent?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Pathophysiology of stroke: lessons from animal models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Cerebral ischemia and the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Oxidants, antioxidants and the ischemic brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Single-dose ebselen does not afford sustained neuroprotection to rats subjected to severe focal cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

A novel system for mild hypothermia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Targeting eNOS for stroke protection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

What have genetically engineered mice taught us about ischemic injury?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Astrocyte influences on ischemic neuronal death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The rise and fall of NMDA antagonists for ischemic stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Excitotoxic versus apoptotic mechanisms of neuronal cell death in perinatal hypoxia/ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Treatment of fever in the neurologic intensive care unit with a catheter-based heat exchange system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Reactive Oxygen Radicals and Pathogenesis of Neuronal Death After Cerebral Ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The role of phospholipases, cyclooxygenases, and lipoxygenases in cerebral ischemic/traumatic injuries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Akt is a molecular target for signal transduction therapy in brain ischemic insult

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Cerebral microvessel responses to focal ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Magnesium sulphate and other anticonvulsants for women with pre-eclampsia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Effects of hypothermia on energy metabolism in Mammalian central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Ischemic tolerance and endogenous neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Signaling of Cell Death and Cell Survival Following Focal Cerebral Ischemia: Life and Death Struggle in the Penumbra

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Oligodendrocytes and ischemic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Ischemia and stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Astrocytes and brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuroprotective agents for the treatment of acute ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

YM872: a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Molecular mechanisms of cerebral ischemia-induced neuronal death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Ischemic tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Role of mitogen- and stress-activated kinases in ischemic injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neurogenesis following brain ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Albumin therapy of transient focal cerebral ischemia: in vivo analysis of dynamic microvascular responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Lubeluzole for acute ischaemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The effect of tirilazad mesylate on infarct volume of patients with acute ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: a bedside-to-bench study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuroprotective effect of treatment with human albumin in permanent focal cerebral ischemia: histopathology and cortical perfusion studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator-treated stroke (CLASS-T): final results

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Stroke genomics: approaches to identify, validate, and understand ischemic stroke gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Programmed cell death in cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Reactive oxygen radicals in signaling and damage in the ischemic brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Delayed neuronal death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Hyperthermia in the neurosurgical intensive care unit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Ischemic penumbra: evidence from functional imaging in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Multiple molecular penumbras after focal cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Calcium antagonists for acute ischemic stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Estrogen as a neuroprotectant in stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Temperature modulation (hypothermic and hyperthermic conditions) and its influence on histological and behavioral outcomes following cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Mediators of cerebral edema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Comparative neuroprotective efficacy of prolonged moderate intraischemic and postischemic hypothermia in focal cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Ischemic brain edema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Recommendations for standards regarding preclinical neuroprotective and restorative drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Inflammatory mediators and stroke: new opportunities for novel therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Piracetam: novelty in a unique mode of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Heat-shock protein protection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Diffusion-weighted magnetic resonance imaging confirms marked neuroprotective efficacy of albumin therapy in focal cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Lubeluzole protects hippocampal neurons from excitotoxicity in vitro and reduces brain damage caused by ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Combating hyperthermia in acute stroke: a significant clinical concern

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Anoxic and Ischemic Injury of Myelinated Axons in CNS White Matter: From Mechanistic Concepts to Therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Astroglial acid-base dynamics in hyperglycemic and normoglycemic global ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Altered Na(+)-channel function as an in vitro model of the ischemic penumbra: action of lubeluzole and other neuroprotective drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Calcium handling by hippocampal neurons under physiologic and pathologic conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Glucose modulation of ischemic brain injury: review and clinical recommendations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuronal apoptosis: current understanding of molecular mechanisms and potential role in ischemic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Transgenic mice and knockout mutants in the study of oxidative stress in brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Autoradiographic and biochemical imaging in cerebral ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Protein phosphorylation and the regulation of mRNA translation following cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Pharmacological effects of the non-competitive NMDA antagonist CNS 1102 in normal volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Glutamate-mediated injury in focal cerebral ischemia: the excitotoxin hypothesis revised.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neurotoxicity of NMDA receptor antagonists: an overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The importance of glutamate receptors in brain ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Calcium: still center-stage in hypoxic-ischemic neuronal death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Nitric oxide synthase inhibition and cerebrovascular regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Cell damage in the brain: a speculative synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Features of astrocytic function apparently involved in the response of central nervous tissue to ischemia-hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Cerebral circulatory and metabolic effects of perivascular neurotransmitters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Albumin--an important extracellular antioxidant?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neurochemical correlates to selective neuronal vulnerability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Pharmacological basis for the use of nimodipine in central nervous system disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Glutamate and the pathophysiology of hypoxic--ischemic brain damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Local metabolic responses to cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

The excitotoxin hypothesis in relation to cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Non-synaptic mechanisms of Ca(2+)-mediated injury in CNS white matter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Selective vulnerability of the hippocampus in brain ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Therapeutic modulation of brain temperature: relevance to ischemic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Experimental antileukocyte interventions in cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Neuroprotective signal transduction: relevance to stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Bright and dark sides of nitric oxide in ischemic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Apoptotic features of selective neuronal death in ischemia, epilepsy and gp 120 toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Brain cooling during transient focal ischemia provides complete neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

27 September 2017

Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--I: Physiological responses and safety results

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--II: neurologic outcome and efficacy analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Long-term effects of clomethiazole in a model of global ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Fiblast (trafermin) in acute stroke: results of the European-Australian phase II/III safety and efficacy trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Use of the CONSORT statement and quality of reports of randomized trials: a comparative before-and-after evaluation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Survival and histological evaluation of therapeutic window of post-ischemia treatment with magnesium sulfate in embolic stroke model of rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

The neuroprotective glycine receptor antagonist GV150526 does not produce neuronal vacuolization or cognitive deficits in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Mechanisms of NO neurotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Pathophysiology of the ischemic penumbra--revision of a concept

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

The effect of high-dose albumin therapy on local cerebral perfusion after transient focal cerebral ischemia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Regulation of the cerebral circulation: role of endothelium and potassium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Neuroprotective efficacy of ebselen, an anti‐oxidant with anti‐inflammatory actions, in a rodent model of permanent middle cerebral artery occlusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Transient Middle Cerebral Artery Occlusion by Intraluminal Suture: II. Neurological Deficits, and Pixel-Based Correlation of Histopathology with Local Blood Flow and Glucose Utilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

The GluR2 (GluR-B) hypothesis: Ca2+-permeable AMPA receptors in neurological disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Postischemic hypothermia. A critical appraisal with implications for clinical treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Gene Expression Induced by Cerebral Ischemia: An Apoptotic Perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Roles of phospholipases A2 in brain cell and tissue injury associated with ischemia and excitotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Blood Flow in the Cerebral Capillary Network: A Review Emphasizing Observations with Intravital Microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

The Glycine Antagonist GV150526 Protects Somatosensory Evoked Potentials and Reduces the Infarct Area in the MCAo Model of Focal Ischemia in the Rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Comparative analysis of brain protection by N-methyl-D-aspartate receptor antagonists after transient focal ischemia in cats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Citicoline for treatment of experimental focal ischemia: histologic and behavioral outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

The effect of chlormethiazole on neuronal damage in a model of transient focal ischaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Quantitative measurement of the total, peroxyl radical-trapping antioxidant capability of human blood plasma by controlled peroxidation. The important contribution made by plasma proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Pentoxifylline in acute nonhemorrhagic stroke. A randomized, placebo-controlled double-blind trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

A controlled trial of nimodipine in acute ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

N-methyl-D-aspartate antagonist reduces stroke size and regional glucose metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Reduction of infarct volume by magnesium after middle cerebral artery occlusion in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Custom-tailored hemodilution with albumin and crystalloids in acute ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

30 May 2018

Cervene in acute ischemic stroke: results of a double-blind, placebo-controlled, dose-comparison study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Overhauling clinical trials.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

A chronic treatment with CDP-choline improves functional recovery and increases neuronal plasticity after experimental stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

The ALIAS (ALbumin In Acute Stroke) Phase III randomized multicentre clinical trial: design and progress report

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Magnesium sulfate neither potentiates nor inhibits tissue plasminogen activator-induced thrombolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Effect of combined therapy with thrombolysis and citicoline in a rat model of embolic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke: methodology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Physician-investigator phone elicitation of consent in the field: a novel method to obtain explicit informed consent for prehospital clinical research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Rectal temperature reflects tympanic temperature during mild induced hypothermia in nonintubated subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy-Magnesium (FAST-MAG) pilot trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Effectively bridging the preclinical/clinical gap: the results of the ASTIN trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Phospholipase A2, Hydroxyl Radicals, and Lipid Peroxidation in Transient Cerebral Ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Haemodilution for acute ischaemic stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Clinical trial of the neuroprotectant clomethiazole in coronary artery bypass graft surgery: a randomized controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on intracerebral hemorrhage in a rabbit Large clot embolic stroke model: combination studies with tissue plasminogen activator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Stilbazulenyl nitrone (STAZN): a nitronyl-substituted hydrocarbon with the potency of classical phenolic chain-breaking antioxidants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Gangliosides for acute ischaemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Buspirone and meperidine synergistically reduce the shivering threshold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Ebselen reduces cytochrome c release from mitochondria and subsequent DNA fragmentation after transient focal cerebral ischemia in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

The neuroprotective activity of the glycine receptor antagonist GV150526: an in vivo study by magnetic resonance imaging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

A randomized efficacy trial of citicoline in patients with acute ischemic stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Posttreatment with high-dose albumin reduces histopathological damage and improves neurological deficit following fluid percussion brain injury in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Clinical stroke trials: guarding against bias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Physiological and pathological operation of glutamate transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Nitric oxide in cerebral ischemic neurodegeneration and excitotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Timing for fever-related brain damage in acute ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Matrix metalloproteinases in cerebrovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Magnesium sulfate therapy in preeclampsia and eclampsia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Multinational randomised controlled trial of lubeluzole in acute ischaemic stroke. European and Australian Lubeluzole Ischaemic Stroke Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Treatment of acute ischemic stroke with piracetam. Members of the Piracetam in Acute Stroke Study (PASS) Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Effect of delayed albumin hemodilution on infarction volume and brain edema after transient middle cerebral artery occlusion in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Neuroprotective effects of preischemia intraarterial magnesium sulfate in reversible focal cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Albumin modulation of capillary permeability: role of endothelial cell [Ca2+]i.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Early treatment of stroke with monosialoganglioside GM-1. Efficacy and safety results of the Early Stroke Trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Nimodipine: a new calcium antagonistic drug with a preferential cerebrovascular action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Functional recovery of cortical neurons as related to degree and duration of ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631228

28 November 2018

Dextran 40 or HES 200/0.5? Hemorheology of the long-term treatment of ischemic cerebral attacks

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GM1 ganglioside therapy in acute ischemic stroke. Italian Acute Stroke Study--Hemodilution + Drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection with lubeluzole against delayed ischemic brain damage in rats. A quantitative histopathologic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diazepam to improve acute stroke outcome: results of the early GABA-Ergic activation study in stroke trial. a randomized double-blind placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potentially critical role of phospholipases in central nervous system ischemic, traumatic, and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of admission body temperature on stroke mortality

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reports of randomized trials in acute stroke, 1955 to 1995. What proportions were commercially sponsored?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II studies of the glycine antagonist GV150526 in acute stroke : the North American experience. The North American Glycine Antagonist in Neuroprotection (GAIN) Investigators

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NXY-059 for the treatment of acute ischemic stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haemodilution in acute stroke: results of the Italian haemodilution trial. Italian Acute Stroke Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of experimental focal ischemia in rats with lubeluzole

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with an AMPA Antagonist 12 Hours following Severe Normothermic Forebrain Ischemia Prevents CA1 Neuronal Injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Termination of Acute Stroke Studies Involving Selfotel Treatment. ASSIST Steering Committed

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti–Intercellular Adhesion Molecule–1 Antibody Reduces Ischemic Cell Damage After Transient But Not Permanent Middle Cerebral Artery Occlusion in the Wistar Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of prolonged treatment with citicoline in temporary experimental focal ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection in acute ischaemic stroke: a tale of for whom the bell tolls?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole International Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusion-weighted MRI of infarct growth in a rat photochemical stroke model: effect of lubeluzole

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multicenter trial of hemodilution in acute ischemic stroke. I. Results in the total patient population. Scandinavian Stroke Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Very Early Nimodipine Use in Stroke (VENUS): a randomized, double-blind, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient Middle Cerebral Artery Occlusion by Intraluminal Suture: I. Three-Dimensional Autoradiographic Image-Analysis of Local Cerebral Glucose Metabolism—Blood Flow Interrelationships during Ischemia and Early Recirculation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flunarizine in stroke treatment (FIST): a double-blind, placebo-controlled trial in Scandinavia and the Netherlands

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: A case-control study: the Copenhagen Stroke Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multicenter trial of hemodilution in acute ischemic stroke. Results of subgroup analyses. Scandinavian Stroke Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypervolemic hemodilution in acute ischemic stroke: the Multicenter Austrian Hemodilution Stroke Trial (MAHST)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clomethiazole protects against hemineglect in a primate model of stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and tolerability of GV150526 (a glycine site antagonist at the N-methyl-D-aspartate receptor) in patients with acute stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety, tolerability, and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke. Dextrorphan Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viability thresholds and the penumbra of focal ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomised, double-blind, placebo-controlled trial of nimodipine in acute stroke. Trust Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trial of nimodipine in acute ischemic stroke. The American Nimodipine Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cervene (Nalmefene) in acute ischemic stroke : final results of a phase III efficacy study. The Cervene Stroke Study Investigators

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stroke treatment--light at the end of the tunnel?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, double-blind, placebo-controlled trial of nimodipine in acute ischemic hemispheric stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical Impact of NXY-059 Demonstrated in the SAINT I Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). The RANTTAS Investigators

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside GM1 in acute ischemic stroke. The SASS Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. GAIN International Investigators

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonergic innervation of the cerebral vasculature: relevance to migraine and ischaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypokalemia, cardiac failure, and reporting NXY-059 safety for acute stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacology of CNS 1102 in volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Albumin affects erythrocyte aggregation and sedimentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18308347

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemia and Stroke

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEUROPHARM.2007.12.007

7 January 2021

based on heuristic

inferred from DOI database lookup

Chapter 12 Protein phosphorylation and the regulation of mRNA translation following cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEUROPHARM.2007.12.007

7 January 2021

based on heuristic

inferred from DOI database lookup

Circadian cholinergic rhythms: implications for cholinesterase inhibitor therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.NEUROPHARM.2007.12.007

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.NEUROPHARM.2007.12.007

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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