(Q24534785)

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The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter

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The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter (English)

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Johnathan R Whetstine

1

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Robin M Flatley

2

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Larry H Matherly

3

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publication date

1 November 2002

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Biochemical Journal

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367

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Pt 3

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629-40

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Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium

1 reference

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Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues

1 reference

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24 March 2017

Molecular cloning of the human placental folate transporter

1 reference

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Toxic leukoencephalopathy

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Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects

1 reference

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Homocysteine and cardiovascular disease

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24 March 2017

The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure

2 references

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24 March 2017

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Folate and carcinogenesis: an integrated scheme

1 reference

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24 March 2017

Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene

1 reference

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MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

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Folate and cancer: A review of the literature

1 reference

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27 September 2017

Molecular and cellular biology of the human reduced folate carrier

1 reference

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A mutation in the 5' untranslated region increases stability of norA mRNA, encoding a multidrug resistance transporter of Staphylococcus aureus

1 reference

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Folic acid antagonists during pregnancy and the risk of birth defects.

1 reference

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Mutations in the reduced-folate carrier affect protein localization and stability

1 reference

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27 September 2017

Carrier-mediated membrane transport of folates in mammalian cells

1 reference

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27 September 2017

Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1).

1 reference

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27 September 2017

Structural organization of the human reduced folate carrier gene: evidence for 5' heterogeneity in lymphoblast mRNA.

1 reference

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27 September 2017

Gene amplification and increased expression of the reduced folate carrier in transport elevated K562 cells

1 reference

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27 September 2017

Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5' end heterogeneity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1222932

27 September 2017

Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line.

1 reference

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27 September 2017

Human intestinal folate transport: cloning, expression, and distribution of complementary RNA.

1 reference

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27 September 2017

Folic acid and the prevention of birth defects

1 reference

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27 September 2017

Organization and alternate splicing of the murine folylpolyglutamate synthetase gene. Different splice variants in L1210 cells encode mitochondrial or cytosolic forms of the enzyme

1 reference

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27 September 2017

Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells

1 reference

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1 reference

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The cellular pharmacology of methotrexate

1 reference

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1 reference

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27 September 2017

The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element. Basis for tissue-specific gene expression

1 reference

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30 May 2018

Tissue-specific expression of functional isoforms of mouse folypoly-gamma-glutamae synthetase: a basis for targeting folate antimetabolites.

1 reference

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30 May 2018

Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.

1 reference

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30 May 2018

Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characteriz

1 reference

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30 May 2018

Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates

1 reference

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30 May 2018

Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport.

1 reference

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30 May 2018

A novel class of genetic variants of the L1210 cell up-regulated for folate analogue transport inward. Isolation, characterization, and degree of metabolic instability of the system.

1 reference

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30 May 2018

Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis

1 reference

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29 November 2018

Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs

1 reference

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1 reference

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29 November 2018

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1 reference

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29 November 2018

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1 reference

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29 November 2018

Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression.

1 reference

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/12144527

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/12144527

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12144527

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https://pubmed.ncbi.nlm.nih.gov/12144527

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/12144527

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1 reference

https://pubmed.ncbi.nlm.nih.gov/12144527

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inferred from PubMed ID database lookup

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10.1042/BJ20020512

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