(Q24530352)

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Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

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Europe PubMed Central

PubMed publication ID

4 July 2017

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid (English)

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Europe PubMed Central

PubMed publication ID

4 July 2017

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Bruce N Ames

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Europe PubMed Central

PubMed publication ID

4 July 2017

author name string

Jiankang Liu

1

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Europe PubMed Central

PubMed publication ID

4 July 2017

Elizabeth Head

2

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Europe PubMed Central

PubMed publication ID

4 July 2017

Afshin M Gharib

3

1 reference

Europe PubMed Central

PubMed publication ID

4 July 2017

Wenjun Yuan

4

1 reference

Europe PubMed Central

PubMed publication ID

4 July 2017

Russell T Ingersoll

5

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Europe PubMed Central

PubMed publication ID

4 July 2017

Tory M Hagen

6

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Europe PubMed Central

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4 July 2017

Carl W Cotman

7

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Europe PubMed Central

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4 July 2017

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1 February 2002

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Europe PubMed Central

PubMed publication ID

4 July 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

4 July 2017

99

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Europe PubMed Central

PubMed publication ID

4 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

4 July 2017

2356-2361

1 reference

Europe PubMed Central

PubMed publication ID

4 July 2017

Oxidants, antioxidants, and the degenerative diseases of aging

1 reference

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24 March 2017

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Developments of a water-maze procedure for studying spatial learning in the rat

1 reference

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7 April 2017

Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122369

27 September 2017

Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

1 reference

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In search of molecular memory: experience-driven protein synthesis

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Protein oxidation.

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Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

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Neuroprotection by the metabolic antioxidant alpha-lipoic acid

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Possible confounding influence of strain, age and gender on cognitive performance in rats

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27 September 2017

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain

1 reference

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2 references

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27 September 2017

https://api.crossref.org/works/10.1073%2FPNAS.261709299

21 January 2018

Oxidative damage and mitochondrial decay in aging

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27 September 2017

Age-related reductions in human recognition memory due to impaired encoding.

1 reference

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27 September 2017

Oxidative base damage in RNA detected by reverse transcriptase

1 reference

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27 September 2017

Inactivation of key metabolic enzymes by mixed-function oxidation reactions: possible implication in protein turnover and ageing

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27 September 2017

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

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27 September 2017

Maze performance: a direct comparison of food vs. water mazes

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27 September 2017

The use of the Morris Water Maze in the study of memory and learning

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27 September 2017

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1 reference

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Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column

1 reference

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27 September 2017

Carnitine function and requirements during the life cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122369

27 September 2017

Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription.

1 reference

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27 September 2017

Norepinephrine infused into the basolateral amygdala posttraining enhances retention in a spatial water maze task

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30 May 2018

Psychomotor and spatial memory performance in aging male Fischer 344 rats.

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30 May 2018

Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task

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30 May 2018

Rotation of water in the Morris water maze interferes with path integration mechanisms of place navigation.

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30 May 2018

Antioxidant treatment with phenyl-alpha-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats

1 reference

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30 May 2018

The effects of AMPA-induced lesions of the medial septum and vertical limb nucleus of the diagonal band of Broca on spatial delayed non-matching to sample and spatial learning in the water maze.

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30 May 2018

Effects of Age on Long-term Memory: Retention of Fixed Interval Responding

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30 May 2018

Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions

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30 May 2018

Arginine vasopressin innoculates against age-related increases in sodium-dependent high affinity choline uptake and discrepancies in the content of temporal memory

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30 May 2018

Age-dependent deficits in radial maze performance in the rat: effect of chronic treatment with acetyl-L-carnitine

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30 May 2018

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30 May 2018

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30 May 2018

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Spatial memory in aged rats: population heterogeneity and effect of levocarnitine acetyl.

1 reference

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30 May 2018

Active avoidance learning in old rats chronically treated with levocarnitine acetyl.

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30 May 2018

Animal models of declining memory in the aged: short-term and spatial memory in the aged rat.

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Decline and preservation of reversal learning abilities and acquisition in the course of senescence.

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Role of protein oxidation in aging and in age-associated neurodegenerative diseases

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The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits.

1 reference

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21 January 2018

Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats

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21 January 2018

Dynamic morphology of the synaptic junctional areas during aging: the effect of chronic acetyl-L-carnitine administration.

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21 January 2018

Spatial memory and NGF levels in aged rats: natural variability and effects of acetyl-L-carnitine treatment

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21 January 2018

Alpha-lipoic acid as a new treatment option for Alzheimer [corrected] type dementia

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21 January 2018

Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone

1 reference

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21 January 2018

Quantification of swim patterns in the Morris water maze.

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21 January 2018

Chronic antioxidant treatment improves the cognitive performance of aged rats.

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https://api.crossref.org/works/10.1073%2FPNAS.261709299

21 January 2018

Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome.

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Mitochondrial abnormalities in Alzheimer's disease.

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RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

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29 November 2018

(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

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The effects of dietary antioxidants on psychomotor performance in aged mice

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12 December 2020

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1 reference

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12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/11854529

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Isolation of an internal clock

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854529

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inferred from PubMed ID database lookup

Characterization of enzymatic acetylcholine synthesis by mouse brain, rat sperm, and purified carnitine acetyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11854529

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Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine

1 reference

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Identifiers

10.1073/PNAS.261709299

1 reference

Europe PubMed Central

PubMed publication ID

4 July 2017

2002PNAS...99.2356L

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 July 2017

ResearchGate publication ID

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