(Q24563393)

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Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes

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Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes (English)

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crystal structure

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protein structure

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endosomal scaffold complex

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Gene Ontology release 2020-05-02

Gene Ontology ID

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

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GOA release 2020-03-11

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

1 reference

GOA release 2020-03-11

Frank Eisenhaber

5

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Sebastian Maurer-Stroh

4

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object named as

David Teis

2

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object named as

Tim Clausen

11

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object named as

Gleb P Bourenkov

6

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object named as

Lukas A Huber

10

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author name string

Robert Kurzbauer

1

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Mariana E G de Araujo

3

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Hans D Bartunik

7

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Mirko Hekman

8

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Ulf R Rapp

9

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language of work or name

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publication date

27 July 2004

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Proceedings of the National Academy of Sciences of the United States of America

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101

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30

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10984-9

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A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

24 March 2017

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

1 reference

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24 March 2017

CNK, a RAF-binding multidomain protein required for RAS signaling

1 reference

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24 March 2017

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

1 reference

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Raster3D: photorealistic molecular graphics

2 references

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24 March 2017

https://api.crossref.org/works/10.1073%2FPNAS.0403435101

22 April 2017

Methods used in the structure determination of bovine mitochondrial F1 ATPase

1 reference

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24 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

2 references

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24 March 2017

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22 April 2017

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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24 March 2017

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1 reference

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24 March 2017

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

24 March 2017

Mammalian MAP kinase signalling cascades

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

24 March 2017

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

24 March 2017

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

24 March 2017

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

7 April 2017

A conserved docking motif in MAP kinases common to substrates, activators and regulators

1 reference

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7 April 2017

Reduced surface: an efficient way to compute molecular surfaces

1 reference

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7 April 2017

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

27 September 2017

The odd couple: signal transduction and endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

27 September 2017

KSR is a scaffold required for activation of the ERK/MAPK module

1 reference

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27 September 2017

The Ste5p scaffold.

1 reference

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27 September 2017

AL2CO: calculation of positional conservation in a protein sequence alignment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

27 September 2017

KSR: a MAPK scaffold of the Ras pathway?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=503730

27 September 2017

Organization and regulation of mitogen-activated protein kinase signaling pathways

1 reference

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27 September 2017

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

1 reference

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27 September 2017

Electrostatic calculations of the pKa values of ionizable groups in bacteriorhodopsin

1 reference

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30 May 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

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21 January 2018

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1 reference

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21 January 2018

Accurate bond and angle parameters for X-ray protein structure refinement

1 reference

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21 January 2018

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

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21 January 2018

Identifiers

10.1073/PNAS.0403435101

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2004PNAS..10110984K

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