(Q24561388)

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Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

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scholarly article

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Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages (English)

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author name string

K Pahan

1

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F G Sheikh

2

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A M Namboodiri

3

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I Singh

4

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language of work or name

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publication date

1 December 1997

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Journal of Clinical Investigation

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100

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11

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2671-9

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Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

24 March 2017

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

24 March 2017

Regulation of the mevalonate pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

7 April 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

7 April 2017

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

7 April 2017

Nitric oxide as a secretory product of mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

7 April 2017

Nitric oxide: a neural messenger

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

p21ras is modified by a farnesyl isoprenoid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

DNA deaminating ability and genotoxicity of nitric oxide and its progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5'-methylthioadenosine: roles of protein isoprenylation and carboxyl methylation reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

The post-translational modification of ras p21 is important for Raf-1 activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Induction of nitric oxide synthase in rat C6 glioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

27 September 2017

Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

30 May 2018

Transcriptional and post-transcriptional analysis of peroxisomal protein encoding genes from rat treated with an hypolipemic agent, ciprofibrate. Effect of an intermittent treatment and influence of obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

30 May 2018

Characterization of ameboid microglia isolated from developing mammalian brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

30 May 2018

Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

30 May 2018

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

30 May 2018

Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

30 May 2018

Phenylacetate: a novel nontoxic inducer of tumor cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

30 May 2018

Increasing cAMP attenuates induction of inducible nitric-oxide synthase in rat primary astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

28 November 2018

Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

28 November 2018

Herbimycin A suppresses NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

28 November 2018

Nitric oxide synthase expression in glial cells: suppression by tyrosine kinase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508470

28 November 2018

Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/9389730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of phenylalanine derivatives on the main regulatory enzymes of hepatic cholesterogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9389730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human astrocyte production of tumour necrosis factor-alpha, interleukin-1 beta, and interleukin-6 following exposure to lipopolysaccharide endotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9389730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/9389730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn

1 reference

https://pubmed.ncbi.nlm.nih.gov/9389730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/9389730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of phenylacetate administered twice daily to patients with cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/9389730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation by cytokines of human astrocyte nitric oxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/9389730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9389730

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI119812

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