(Q24324360)

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Activation of Raf-1 by 14-3-3 proteins

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Activation of Raf-1 by 14-3-3 proteins (English)

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1

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W J Fantl

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Lewis T. Williams

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L T Williams

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A J Muslin

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A Kikuchi

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J A Martin

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A M MacNicol

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R W Gross

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publication date

13 October 1994

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371

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6498

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612-4

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Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

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Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF

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Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

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Activation of the MAP kinase pathway by the protein kinase raf

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Raf-1 activates MAP kinase-kinase

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Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

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Complex formation between RAS and RAF and other protein kinases

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

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Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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Activation of Raf as a result of recruitment to the plasma membrane

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A novel genetic system to detect protein-protein interactions

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins

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14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins

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Primary structure of a human protein kinase regulator protein

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Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway

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14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast

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Association of polyomavirus middle tumor antigen with 14-3-3 proteins

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Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

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Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos

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The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

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10.1038/371612A0

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