(Q22010813)

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The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

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The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity (English)

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Furin, paired basic amino acid cleaving enzyme

1 reference

GOA release 2020-03-11

negative regulation of nerve growth factor production

1 reference

GOA release 2020-03-11

author name string

M Zhong

1

author given names

M

author last names

Zhong

1 reference

PubMed publication ID

7 February 2023

J S Munzer

2

author given names

J S

author last names

Munzer

1 reference

PubMed publication ID

7 February 2023

A Basak

3

author given names

A

author last names

Basak

1 reference

PubMed publication ID

7 February 2023

S Benjannet

4

author given names

S

author last names

Benjannet

1 reference

PubMed publication ID

7 February 2023

S J Mowla

5

author given names

S J

author last names

Mowla

1 reference

PubMed publication ID

7 February 2023

E Decroly

6

author given names

E

author last names

Decroly

1 reference

PubMed publication ID

7 February 2023

M Chrétien

7

author given names

M

author last names

Chrétien

1 reference

PubMed publication ID

7 February 2023

N G Seidah

8

author given names

N G

author last names

Seidah

1 reference

PubMed publication ID

7 February 2023

language of work or name

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publication date

26 November 1999

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Journal of Biological Chemistry

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274

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48

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33913-20

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Inhibition of processing of parathyroid hormone‐related peptide by anti‐sense furin: Effect in vitro and in vivo on rat leydig (H‐500) tumor cells

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A novel peptide designated PYLa and its precursor as predicted from cloned mRNA of Xenopus laevis skin

1 reference

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Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Subtilases: the superfamily of subtilisin-like serine proteases

1 reference

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7 January 2021

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Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

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Folding Pathway Mediated by an Intramolecular Chaperone: Characterization of the Structural Changes in Pro-subtilisin E Coincident with Autoprocess ing

1 reference

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Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells

1 reference

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A novel Kex2 enzyme can process the proregion of the yeast alpha-factor leader in the endoplasmic reticulum instead of in the Golgi

1 reference

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Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

1 reference

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Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform

1 reference

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based on heuristic

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Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160

1 reference

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7 January 2021

based on heuristic

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The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: comparison with PC5, furin and PC7, implication in pro-BDNF processing

1 reference

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based on heuristic

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Eukaryotic protein processing: endoproteolysis of precursor proteins

1 reference

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7 January 2021

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Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

1 reference

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based on heuristic

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The proprotein convertases

1 reference

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Catalysis of a protein folding reaction: thermodynamic and kinetic analysis of subtilisin BPN' interactions with its propeptide fragment.

1 reference

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Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family

1 reference

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based on heuristic

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Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

1 reference

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based on heuristic

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The effect of pH on the affinities of enzymes for substrates and inhibitors

1 reference

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7 January 2021

based on heuristic

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A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of intracellular proteolytic processing of soluble proproteins by an engineered α2-macroglobulin containing a furin recognition sequence in the bait region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Secretion and autoproteolytic maturation of subtilisin

1 reference

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Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

1 reference

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Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease

1 reference

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based on heuristic

inferred from DOI database lookup

cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Processing of the Ebola virus glycoprotein by the proprotein convertase furin

1 reference

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based on heuristic

inferred from DOI database lookup

alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

1 reference

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based on heuristic

inferred from DOI database lookup

Fluorescent Peptidyl Substrates as an Aid in Studying the Substrate Specificity of Human Prohormone Convertase PC1 and Human Furin and Designing a Potent Irreversible Inhibitor

1 reference

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based on heuristic

inferred from DOI database lookup

Structural Elements That Direct Specific Processing of Different Mammalian Subtilisin-like Prohormone Convertases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

1 reference

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Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing

1 reference

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based on heuristic

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In vitro characterization of the novel proprotein convertase PC7.

1 reference

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based on heuristic

inferred from DOI database lookup

Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

1 reference

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7 January 2021

based on heuristic

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Biosynthesis, Distinct Post-translational Modifications, and Functional Characterization of Lymphoma Proprotein Convertase

1 reference

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based on heuristic

inferred from DOI database lookup

Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of Soluble Recombinant Furin by Human Proteinase Inhibitor 8

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The Pore-forming Toxin Proaerolysin Is Activated by Furin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of mouse CPX-1, a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.48.33913

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

1 reference

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7 January 2021

based on heuristic

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New vaccinia virus recombination plasmids incorporating a synthetic late promoter for high level expression of foreign proteins

1 reference

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based on heuristic

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Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Histidine‐rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Determinants for protein translocation across mammalian endoplasmic reticulum. Membrane insertion of truncated and full-length prelysozyme molecules

1 reference

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based on heuristic

inferred from DOI database lookup

Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

inferred from DOI database lookup

Activation of the Kexin from Schizosaccharomyces pombe Requires Internal Cleavage of Its Initially Cleaved Prosequence

1 reference

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based on heuristic

inferred from DOI database lookup

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10.1074/JBC.274.48.33913

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