(Q21992503)

Rap/Ran-GAP superfamily

1 reference

Armadillo-type fold

1 reference

Tuberin-type domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rap GTPase activating protein domain family

1 reference

based on heuristic

inferred from protein domain or family

Tuberin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

20 March 2016

language of work or name

English

Haplophyllum tuberculatum

1 reference

Alkaloids from Haplophyllum tuberculatum

1 reference

20 March 2016

language of work or name

English

molecular function

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

GTPase activator activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14-3-3 protein binding

1 reference

14 February 2019

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

small GTPase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein binding

3 references

14 February 2019

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein N-terminus binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

Hsp90 protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

cell component

cytoplasm

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61037&geneProductId=UniProtKB:Q61037

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61037&geneProductId=UniProtKB:Q61037

24 April 2018

24 April 2018

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61037&geneProductId=UniProtKB:Q61037

cytosol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

TSC1-TSC2 complex

perinuclear region of cytoplasm

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

lysosome

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

1 reference

14 February 2019

cytoskeleton

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

caveola

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

dendrite

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

growth cone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

cell projection

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

neuron projection

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

soma

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

intracellular membrane-bounded organelle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

membrane raft

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

cytoplasm

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

14 February 2019

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

postsynaptic density

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

glutamatergic synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

regulation of endocytosis

biological process

1 reference

14 February 2019

Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein localization

1 reference

14 February 2019

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

insulin-like growth factor receptor signaling pathway

negative regulation of protein kinase B signaling

response to hypoxia

1 reference

14 February 2019

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein import into nucleus

1 reference

14 February 2019

Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of protein kinase activity

1 reference

14 February 2019

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

positive regulation of autophagy

1 reference

14 February 2019

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of phosphatidylinositol 3-kinase signaling

1 reference

14 February 2019

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

regulation of cell cycle

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

heart development

1 reference

14 February 2019

Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

neural tube closure

1 reference

14 February 2019

Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

positive regulation of GTPase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

1 reference

14 February 2019

negative regulation of insulin receptor signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

cell projection organization

1 reference

14 February 2019

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

cellular response to insulin stimulus

1 reference

14 February 2019

The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

phosphatidylinositol 3-kinase signaling

1 reference

14 February 2019

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

glucose import

1 reference

14 February 2019

The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

positive chemotaxis

1 reference

14 February 2019

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

regulation of small GTPase mediated signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

1 reference

14 February 2019

negative regulation of TORC1 signaling

1 reference

14 February 2019

Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of cell size

1 reference

14 February 2019

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein transport into plasma membrane raft

1 reference

14 February 2019

The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

regulation of insulin receptor signaling pathway

1 reference

14 February 2019

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

positive regulation of macroautophagy

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of TOR signaling

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61037&geneProductId=UniProtKB:Q61037

24 April 2018

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61037&geneProductId=UniProtKB:Q61037

24 April 2018

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61037&geneProductId=UniProtKB:Q61037

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61037&geneProductId=UniProtKB:Q61037

24 April 2018

negative regulation of protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

ageing

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of cell population proliferation

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of epithelial to mesenchymal transition

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

positive regulation of fibroblast migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

positive regulation of neuron projection development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of macroautophagy

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

establishment of cell polarity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein localization to cell surface

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

social behavior

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of MAP kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

establishment of protein localization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

positive regulation of cell adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of fibroblast proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of pinocytosis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of epithelial cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of axonogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein homooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

protein heterooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

positive regulation of dendritic spine development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of vascular endothelial cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of TOR signaling

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

negative regulation of protein kinase B signaling

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

regulation of postsynapse organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61037

1 reference

Rap GTPase activating protein domain

1 reference

Tuberin-type domain

1 reference