(Q21992241)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O54885

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

10 references

8 April 2019

Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

signaling receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

1 reference

8 April 2019

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

1 reference

8 April 2019

cell surface

3 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

1 reference

14 February 2019

TAS

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

1 reference

8 April 2019

cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

integrin-mediated signaling pathway

biological process

1 reference

8 April 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

macrophage activation involved in immune response

1 reference

8 April 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

regulation of osteoclast development

IGI

1 reference

8 April 2019

Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

neutrophil activation involved in immune response

IGI

1 reference

8 April 2019

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

osteoclast differentiation

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

myeloid leukocyte activation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54885&geneProductId=UniProtKB:O54885

positive regulation of natural killer cell activation

1 reference

8 April 2019

Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

positive regulation of microglial cell mediated cytotoxicity

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

positive regulation of protein localization to cell surface

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O54885&geneProductId=UniProtKB:O54885

positive regulation of osteoclast development

1 reference

8 April 2019

The signaling adapter protein DAP12 regulates multinucleation during osteoclast development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

microglial cell activation involved in immune response

positive regulation of gene expression

1 reference

8 April 2019

A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

actin cytoskeleton organization

1 reference

8 April 2019

DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

forebrain development

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

negative regulation of transforming growth factor beta1 production

1 reference

8 April 2019

A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

positive regulation of superoxide anion generation

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

positive regulation of macrophage fusion

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

Essential role of DAP12 signaling in macrophage programming into a fusion-competent state

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

response to axon injury

1 reference

8 April 2019

A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

protein stabilization

apoptotic signaling pathway

ISS

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

positive regulation of hippocampal neuron apoptotic process

1 reference

8 April 2019

Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

negative regulation of long-term synaptic potentiation

1 reference

8 April 2019

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

positive regulation of neuron death

1 reference

8 April 2019

A DAP12-dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

positive regulation of receptor localization to synapse

1 reference

8 April 2019

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

negative regulation of B cell proliferation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

apoptotic cell clearance

1 reference

8 April 2019

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54885

1 reference

8 April 2019