(Q21986192)

Notch-like domain superfamily

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Ankyrin repeat-containing domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Notch, NODP domain, protein family

1 reference

Notch proteins

1 reference

Notch, NOD domain, protein family

1 reference

Domain of unknown function DUF3454, notch, protein family

1 reference

Ankyrin repeat-containing domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

Ankyrin repeat, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

9 May 2019

NF-kappaB binding

1 reference

9 May 2019

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

protein binding

4 references

9 May 2019

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

9 May 2019

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

9 May 2019

Notch signaling in kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

9 May 2019

RBP-L, a transcription factor related to RBP-Jkappa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

enzyme binding

1 reference

9 May 2019

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

signaling receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

9 May 2019

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

9 May 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

9 May 2019

receptor complex

1 reference

9 May 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

plasma membrane

1 reference

9 May 2019

A role for the primary cilium in Notch signaling and epidermal differentiation during skin development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

9 May 2019

nucleus

3 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

9 May 2019

biological process

Notch signaling pathway

Segmental expression of Notch and Hairy genes in nephrogenesis

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

9 May 2019

9 May 2019

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

pulmonary valve morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

9 May 2019

glomerular visceral epithelial cell development

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

inflammatory response to antigenic stimulus

1 reference

9 May 2019

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

multicellular organism growth

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

placenta development

1 reference

9 May 2019

Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

placenta blood vessel development

1 reference

9 May 2019

Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

wound healing

1 reference

9 May 2019

Notch signaling in kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

myeloid dendritic cell differentiation

1 reference

9 May 2019

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

positive regulation of osteoclast differentiation

1 reference

9 May 2019

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

in utero embryonic development

1 reference

9 May 2019

Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

marginal zone B cell differentiation

1 reference

9 May 2019

Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

ciliary body morphogenesis

1 reference

9 May 2019

Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

glomerular capillary formation

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35516&geneProductId=UniProtKB:O35516

1 reference

24 April 2018

heart looping

1 reference

9 May 2019

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

proximal tubule development

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

intrahepatic bile duct development

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

determination of left/right symmetry

1 reference

9 May 2019

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

hepatocyte proliferation

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

regulation of developmental process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

9 May 2019

humoral immune response

1 reference

9 May 2019

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

embryonic limb morphogenesis

1 reference

9 May 2019

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

defense response to bacterium

1 reference

9 May 2019

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

bone remodeling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

positive regulation of cell population proliferation

1 reference

9 May 2019

Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

positive regulation of BMP signaling pathway

1 reference

9 May 2019

Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

animal organ morphogenesis

1 reference

9 May 2019

Notch signaling in kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

positive regulation of apoptotic process

1 reference

9 May 2019

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

cholangiocyte proliferation

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

liver development

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

morphogenesis of an epithelial sheet

1 reference

9 May 2019

A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

left/right axis specification

1 reference

9 May 2019

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

liver morphogenesis

1 reference

9 May 2019

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

negative regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

positive regulation of keratinocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

8 April 2019

regulation of actin cytoskeleton reorganization

ISS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35516

1 reference

8 April 2019

ankyrin repeat-containing domain

ISS

has part(s)

1 reference

Notch domain

1 reference

EGF-like calcium-binding, conserved site

1 reference

EGF-like calcium-binding domain

1 reference

EGF-like, conserved site

1 reference

Notch, NOD domain

1 reference

EGF-type aspartate/asparagine hydroxylation site

1 reference

Notch, NODP domain

1 reference

EGF-like domain

1 reference

ankyrin repeat

1 reference

Domain of unknown function DUF3454, notch

1 reference