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Wikidata

(Q21985207)

English

Polycystin 2, transient receptor potential cation channel

mammalian protein found in Mus musculus

  • Pkd2
  • transient receptor potential cation channel subfamily P member 2
  • polycystin 2
  • polycystic kidney disease 2 protein homolog
  • polycystin-2
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
10 references
retrieved
9 May 2019
stated in
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
retrieved
9 May 2019
stated in
Nek8 regulates the expression and localization of polycystin-1 and polycystin-2
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
retrieved
9 May 2019
stated in
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
retrieved
9 May 2019
stated in
Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
retrieved
9 May 2019
stated in
PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
retrieved
9 May 2019
stated in
Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
retrieved
9 May 2019
stated in
Molecular cloning, genomic structure, and protein characterization of mouse optineurin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
retrieved
9 May 2019
stated in
In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
retrieved
9 May 2019
stated in
Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
retrieved
9 May 2019
stated in
Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IPI
calcium channel activity
determination method or standard
IBA
IDA
IEA
IMP
TAS
6 references
retrieved
7 November 2018
stated in
PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245
determination method or standard
TAS
retrieved
7 November 2018
stated in
The native TRPP2-dependent channel of murine renal primary cilia
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245
determination method or standard
IMP
retrieved
7 November 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245
determination method or standard
IEA
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245
determination method or standard
IEA
retrieved
7 November 2018
stated in
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
7 November 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245
determination method or standard
IBA
calcium channel activity
determination method or standard
IBA
IDA
IEA
IMP
ISO
TAS
7 references
retrieved
9 May 2019
stated in
PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
TAS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
ISO
retrieved
9 May 2019
stated in
The native TRPP2-dependent channel of murine renal primary cilia
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IEA
retrieved
9 May 2019
stated in
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IBA
cell component
cilium
determination method or standard
IDA
IEA
IMP
9 references
retrieved
14 February 2019
stated in
Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IEA
retrieved
14 February 2019
stated in
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
14 February 2019
stated in
Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
14 February 2019
stated in
A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
14 February 2019
stated in
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
14 February 2019
stated in
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
14 February 2019
stated in
A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
14 February 2019
stated in
Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
endoplasmic reticulum
determination method or standard
IEA
IDA
TAS
IMP
ISO
7 references
retrieved
9 May 2019
stated in
In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
TAS
retrieved
9 May 2019
stated in
Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
ISO
retrieved
9 May 2019
stated in
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IEA
retrieved
9 May 2019
stated in
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
9 May 2019
stated in
A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
cilium
determination method or standard
IDA
IEA
IMP
ISO
12 references
retrieved
9 May 2019
stated in
Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
ISO
retrieved
9 May 2019
stated in
Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IEA
retrieved
9 May 2019
stated in
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
O35245
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
9 May 2019
stated in
Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
9 May 2019
stated in
A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
9 May 2019
stated in
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
9 May 2019
stated in
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
9 May 2019
stated in
Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
9 May 2019
stated in
A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
retrieved
9 May 2019
stated in
Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245
determination method or standard
IDA
biological process

Identifiers

 
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