(Q21984127)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70444

Blc2-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70444

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Apoptosis regulator, Bcl-2, BH3 motif, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

7 references

14 February 2019

Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

An interconnected hierarchical model of cell death regulation by the BCL-2 family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Structural plasticity underpins promiscuous binding of the prosurvival protein A1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

ubiquitin protein ligase binding

1 reference

14 February 2019

The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

27 February 2018

27 February 2018

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

tBid undergoes multiple conformational changes at the membrane required for Bax activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

mitochondrial membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

1 reference

14 February 2019

integral component of mitochondrial membrane

1 reference

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

4 references

27 February 2018

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

27 February 2018

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

27 February 2018

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

cytosol

5 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

27 February 2018

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

27 February 2018

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

mitochondrion

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

mitochondrial outer membrane

HDA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

cytosol

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

positive regulation of protein homooligomerization

biological process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

BH3 domains other than Bim and Bid can directly activate Bax/Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

response to estradiol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

extrinsic apoptotic signaling pathway

1 reference

14 February 2019

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

signal transduction in response to DNA damage

TAS

1 reference

14 February 2019

No death without life: vital functions of apoptotic effectors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

regulation of protein oligomerization

TAS

1 reference

14 February 2019

Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

protein targeting to mitochondrion

1 reference

14 February 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

regulation of mitochondrial membrane permeability involved in apoptotic process

glial cell apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

regulation of G1/S transition of mitotic cell cycle

1 reference

14 February 2019

Deletion of Bid impedes cell proliferation and hepatic carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

brain development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

regulation of cell population proliferation

1 reference

14 February 2019

Deletion of Bid impedes cell proliferation and hepatic carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

apoptotic mitochondrial changes

1 reference

27 February 2018

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

positive regulation of release of cytochrome c from mitochondria

4 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

ISO

27 February 2018

BH3 domains other than Bim and Bid can directly activate Bax/Bak

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

27 February 2018

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

protein homooligomerization

1 reference

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

27 February 2018

Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70444&geneProductId=UniProtKB:P70444

mitochondrial outer membrane permeabilization

1 reference

14 February 2019

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

hepatocyte apoptotic process

1 reference

14 February 2019

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

release of cytochrome c from mitochondria

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

ISO

14 February 2019

Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

1 reference

14 February 2019

positive regulation of mitochondrial membrane potential

1 reference

14 February 2019

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

mitochondrial ATP synthesis coupled electron transport

1 reference

14 February 2019

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

positive regulation of apoptotic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

14 February 2019

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

positive regulation of fibroblast apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

positive regulation of apoptotic signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

response to ischemia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

activation of cysteine-type endopeptidase activity involved in apoptotic process

apoptotic mitochondrial changes

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

positive regulation of release of cytochrome c from mitochondria

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

ISO

14 February 2019

BH3 domains other than Bim and Bid can directly activate Bax/Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

positive regulation of extrinsic apoptotic signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

positive regulation of intrinsic apoptotic signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70444

Apoptosis regulator, Bcl-2, BH3 motif, conserved site

has part(s)

1 reference

InterPro Release 71.0