(Q21982891)

Cyclin-like, protein family

1 reference

Retinoblastoma-associated protein, N-terminal domain, protein family

1 reference

Retinoblastoma-associated protein, B-box family

1 reference

Retinoblastoma-associated protein, C-terminal domain, protein family

1 reference

Retinoblastoma-associated protein, A-box family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

1 reference

9 May 2019

transcription factor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

5 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

kinase binding

16 references

9 May 2019

Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

LEK1 is a potential inhibitor of pocket protein-mediated cellular processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Role of mammalian Ecdysoneless in cell cycle regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Binding of an interferon-inducible protein (p202) to the retinoblastoma protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

RB regulates pancreas development by stabilizing Pdx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Interaction of the pRB-family proteins with factors containing paired-like homeodomains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

LEK1 is a potential inhibitor of pocket protein-mediated cellular processes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

enzyme binding

1 reference

9 May 2019

The arginine methyltransferase PRMT2 binds RB and regulates E2F function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

cis-regulatory region sequence-specific DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

DNA-binding transcription repressor activity, RNA polymerase II-specific

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

cell component

PML body

transcription regulator complex

1 reference

5 June 2018

C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

spindle

1 reference

9 May 2019

Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

9 references

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

5 June 2018

C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

5 June 2018

Role of Fgf10 in cell proliferation in white adipose tissue

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

5 June 2018

Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

5 June 2018

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

cyclin/CDK positive transcription elongation factor complex

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

nucleoplasm

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

10 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Role of Fgf10 in cell proliferation in white adipose tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

Rb-E2F complex

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

biological process

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

1 reference

9 May 2019

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

1 reference

5 June 2018

negative regulation of smoothened signaling pathway

1 reference

9 May 2019

pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of protein kinase activity

cell morphogenesis involved in neuron differentiation

1 reference

5 June 2018

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

negative regulation of transcription involved in G1/S transition of mitotic cell cycle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

regulation of transcription by RNA polymerase II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

1 reference

9 May 2019

positive regulation of macrophage differentiation

1 reference

9 May 2019

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

cellular response to xenobiotic stimulus

1 reference

9 May 2019

RB tumor suppressive function in response to xenobiotic hepatocarcinogens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of cell cycle

1 reference

14 February 2019

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of transcription by RNA polymerase II

Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

1 reference

5 June 2018

glial cell apoptotic process

1 reference

9 May 2019

Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

neuron maturation

1 reference

9 May 2019

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

cell division

1 reference

9 May 2019

The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

enucleate erythrocyte differentiation

1 reference

9 May 2019

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

neuron differentiation

1 reference

5 June 2018

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

negative regulation of epithelial cell proliferation

1 reference

9 May 2019

pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

skeletal muscle cell differentiation

1 reference

9 May 2019

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

1 reference

9 May 2019

striated muscle cell differentiation

1 reference

9 May 2019

Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

Ras protein signal transduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

myoblast differentiation

digestive tract development

1 reference

9 May 2019

pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of transcription, DNA-templated

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

neuron projection development

1 reference

5 June 2018

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13405&geneProductId=UniProtKB:P13405

positive regulation of transcription by RNA polymerase II

Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of cell population proliferation

The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear.

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

regulation of lipid kinase activity

negative regulation of mitotic cell cycle

1 reference

9 May 2019

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

hepatocyte apoptotic process

1 reference

9 May 2019

Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

tissue homeostasis

1 reference

9 May 2019

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of gene expression

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

regulation of cell growth

1 reference

9 May 2019

Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

G1/S transition of mitotic cell cycle

1 reference

9 May 2019

Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

chromatin organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

1 reference

9 May 2019

negative regulation of hepatocyte apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

aortic valve morphogenesis

1 reference

9 May 2019

Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of inflammatory response

1 reference

9 May 2019

Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

positive regulation of extracellular matrix organization

1 reference

9 May 2019

Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

positive regulation of collagen fibril organization

1 reference

9 May 2019

Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of myofibroblast differentiation

1 reference

9 May 2019

Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

regulation of mitotic cell cycle

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

cell differentiation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

cell morphogenesis involved in neuron differentiation

negative regulation of cold-induced thermogenesis

1 reference

9 May 2019

Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of G1/S transition of mitotic cell cycle

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of protein serine/threonine kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of tau-protein kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

negative regulation of apoptotic signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13405

Retinoblastoma-associated protein, C-terminal

has part(s)

1 reference

Cyclin-like

1 reference

Retinoblastoma-associated protein, B-box

1 reference

Retinoblastoma-associated protein, A-box

1 reference

Retinoblastoma-associated protein, N-terminal

1 reference