(Q21981008)

Immunoglobulin-like fold

1 reference

Immunoglobulin-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Immunoglobulin subtype 2, protein family

1 reference

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

inferred from protein domain or family

Phosphorylated immunoreceptor signalling ITAM, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

signal transducer activity

1 reference

4 April 2017

Essential role for ZAP-70 in both positive and negative selection of thymocytes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

transmembrane signaling receptor activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

1 reference

4 April 2017

protein binding

IPI

1 reference

8 April 2019

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

integral component of membrane

IPI

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

1 reference

8 April 2019

cell-cell junction

1 reference

8 April 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

alpha-beta T cell receptor complex

plasma membrane

external side of plasma membrane

ISO

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection

14 references

4 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

Essential role for ZAP-70 in both positive and negative selection of thymocytes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

plasma membrane

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

external side of plasma membrane

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection

15 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

alpha-beta T cell receptor complex

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

dendritic spine

1 reference

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

cell body

1 reference

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

biological process

lymphocyte activation

1 reference

8 April 2019

Negative regulation of lymphocyte activation by the adaptor protein LAX

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

T cell costimulation

1 reference

8 April 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

T cell differentiation in thymus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

positive regulation of alpha-beta T cell proliferation

3 references

8 April 2019

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

positive regulation of interferon-gamma production

1 reference

8 April 2019

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

positive regulation of interleukin-4 production

1 reference

8 April 2019

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

positive regulation of T cell anergy

1 reference

8 April 2019

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

cell surface receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

3 references

4 April 2017

4 April 2017

Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

4 April 2017

Essential role for ZAP-70 in both positive and negative selection of thymocytes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

negative regulation of smoothened signaling pathway

1 reference

8 April 2019

Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

apoptotic signaling pathway

1 reference

8 April 2019

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

positive regulation of T cell activation

1 reference

8 April 2019

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

T cell receptor signaling pathway

1 reference

8 April 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

1 reference

8 April 2019

negative thymic T cell selection

1 reference

8 April 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

positive regulation of T cell proliferation

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

response to nutrient

1 reference

4 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P22646

positive regulation of cell-matrix adhesion

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

adaptive immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

1 reference

8 April 2019

cell surface receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

4 references

8 April 2019

8 April 2019

Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Essential role for ZAP-70 in both positive and negative selection of thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

response to nutrient

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

ISO

dendrite development

1 reference

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

cerebellum development

1 reference

8 April 2019

CD3 and immunoglobulin G Fc receptor regulate cerebellar functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

T cell differentiation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

positive regulation of cell-cell adhesion mediated by integrin

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

positive thymic T cell selection

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22646

Phosphorylated immunoreceptor signalling ITAM

has part(s)

1 reference

immunoglobulin subtype 2

1 reference

immunoglobulin-like domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016