(Q21494765)

P-loop containing nucleoside triphosphate hydrolase

1 reference

inferred from protein domain or family

AAA proteins

1 reference

based on heuristic

ABC transporter-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

ABC transporter, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

1 reference

9 May 2019

phospholipid transporter activity

1 reference

9 May 2019

Potential role of ABCA7 in cellular lipid efflux to apoA-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

protein binding

IPI

1 reference

9 May 2019

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

phosphatidylcholine floppase activity

IPI

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

phosphatidylserine floppase activity

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

lipid transporter activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

protein binding

apolipoprotein A-I receptor activity

IPI

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

cell component

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

1 reference

9 May 2019

early endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

1 reference

9 May 2019

intracellular membrane-bounded organelle

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

Golgi membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

1 reference

9 May 2019

plasma membrane

ISS

intracellular anatomical structure

1 reference

10 September 2018

Potential role of ABCA7 in cellular lipid efflux to apoA-I

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

ruffle membrane

1 reference

1 January 2018

ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

cell surface

2 references

9 May 2019

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

apical plasma membrane

1 reference

9 May 2019

Potential role of ABCA7 in cellular lipid efflux to apoA-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

phagocytic cup

1 reference

1 January 2018

ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

cell junction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

cytoplasm

1 reference

1 January 2018

ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

glial cell projection

1 reference

9 May 2019

ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

1 reference

9 May 2019

positive regulation of phagocytosis

biological process

positive regulation of amyloid-beta clearance

1 reference

9 May 2019

Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

negative regulation of amyloid-beta formation

memory

1 reference

9 May 2019

Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

positive regulation of engulfment of apoptotic cell

1 reference

9 May 2019

ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

peptide cross-linking

1 reference

9 May 2019

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

positive regulation of cholesterol efflux

1 reference

9 May 2019

ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

negative regulation of amyloid precursor protein biosynthetic process

1 reference

9 May 2019

ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

1 reference

9 May 2019

protein localization to nucleus

1 reference

9 May 2019

ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

positive regulation of phospholipid efflux

1 reference

9 May 2019

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

1 reference

9 May 2019

apolipoprotein A-I-mediated signaling pathway

2 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

11 October 2018

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

phospholipid translocation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

lipid transport

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

cholesterol efflux

3 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

phospholipid efflux

3 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

11 October 2018

Potential role of ABCA7 in cellular lipid efflux to apoA-I

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

cholesterol efflux

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

phospholipid efflux

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

Potential role of ABCA7 in cellular lipid efflux to apoA-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

amyloid-beta formation

1 reference

1 January 2018

ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q91V24&geneProductId=UniProtKB:Q91V24

apolipoprotein A-I-mediated signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

9 May 2019

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

negative regulation of endocytosis

1 reference

9 May 2019

ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

amyloid-beta clearance by cellular catabolic process

1 reference

9 May 2019

ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

plasma membrane raft organization

1 reference

9 May 2019

ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

regulation of amyloid precursor protein catabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

positive regulation of protein localization to cell surface

1 reference

9 May 2019

ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91V24

1 reference

ABC transporter-like

1 reference

ABC transporter, conserved site

1 reference