(Q21139116)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q08117

Groucho/TLE, N-terminal Q-rich domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

7 references

8 April 2019

Six3 and Six6 activity is modulated by members of the groucho family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

transcription corepressor activity

Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08117&geneProductId=UniProtKB:Q08117

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08117&geneProductId=UniProtKB:Q08117

5 June 2018

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08117&geneProductId=UniProtKB:Q08117

identical protein binding

1 reference

5 June 2018

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08117&geneProductId=UniProtKB:Q08117

transcription corepressor activity

Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

transcription corepressor activity

Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

1 January 2018

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08117&geneProductId=UniProtKB:Q08117

3 references

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08117&geneProductId=UniProtKB:Q08117

5 June 2018

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08117&geneProductId=UniProtKB:Q08117

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

transcription regulator complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

animal organ morphogenesis

biological process

1 reference

8 April 2019

Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of Split Groucho protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

multicellular organism development

1 reference

8 April 2019

Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

positive regulation of anoikis

1 reference

8 April 2019

A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

response to interleukin-1

1 reference

8 April 2019

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

1 reference

8 April 2019

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

1 reference

8 April 2019

negative regulation of protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

negative regulation of canonical Wnt signaling pathway

1 reference

5 June 2018

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08117&geneProductId=UniProtKB:Q08117

negative regulation of gene expression

1 reference

8 April 2019

A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08117&geneProductId=UniProtKB:Q08117

1 reference

5 June 2018

negative regulation of response to cytokine stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

skeletal system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

cellular response to extracellular stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

regulation of growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

negative regulation of canonical Wnt signaling pathway

negative regulation of transcription, DNA-templated

1 reference

1 January 2018

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08117

Groucho/TLE, N-terminal Q-rich domain

has part(s)

1 reference

InterPro Release 71.0