(Q21132154)

http://www.ebi.ac.uk/interpro/protein/P20160

InterPro Release 71.0

reference URL

Peptidase S1, PA clan

1 reference

http://www.ebi.ac.uk/interpro/protein/P20160

InterPro Release 71.0

reference URL

Serine proteases, trypsin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Neutrophil-derived azurocidin cleaves insulin-like growth factor-binding protein-1, -2 and -4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

protein binding

IPI

1 reference

8 April 2019

Basic residues in azurocidin/HBP contribute to both heparin binding and antimicrobial activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

heparan sulfate proteoglycan binding

IPI

1 reference

8 April 2019

Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

toxic substance binding

1 reference

8 April 2019

Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

serine-type endopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20160&geneProductId=UniProtKB:P20160

1 reference

26 September 2017

serine-type endopeptidase activity

IBA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

1 reference

8 April 2019

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

1 reference

8 April 2019

azurophil granule

1 reference

26 September 2017

Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20160&geneProductId=UniProtKB:P20160

azurophil granule membrane

1 reference

8 April 2019

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

extracellular exosome

extrinsic component of membrane

1 reference

8 April 2019

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

extracellular space

azurophil granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

1 reference

8 April 2019

azurophil granule

IBA

positive regulation of MHC class II biosynthetic process

biological process

1 reference

8 April 2019

Activation of microglia: a neuroinflammatory role for CAP37

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

positive regulation of phagocytosis

1 reference

8 April 2019

Activation of microglia: a neuroinflammatory role for CAP37

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

negative regulation of apoptotic process

1 reference

8 April 2019

Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

protein kinase C signaling

1 reference

8 April 2019

CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

microglial cell activation

1 reference

8 April 2019

Activation of microglia: a neuroinflammatory role for CAP37

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

induction of positive chemotaxis

1 reference

8 April 2019

Activation of microglia: a neuroinflammatory role for CAP37

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

monocyte activation

1 reference

8 April 2019

Activation of microglia: a neuroinflammatory role for CAP37

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

1 reference

8 April 2019

regulation of vascular permeability

1 reference

8 April 2019

Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

positive regulation of gene expression

1 reference

8 April 2019

CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

macrophage chemotaxis

1 reference

8 April 2019

Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

protein kinase C-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Activation of microglia: a neuroinflammatory role for CAP37

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

defense response to bacterium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

1 reference

8 April 2019

positive regulation of peptidyl-threonine phosphorylation

1 reference

8 April 2019

CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

neutrophil-mediated killing of bacterium

1 reference

8 April 2019

Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

defense response to Gram-negative bacterium

1 reference

8 April 2019

Activation of microglia: a neuroinflammatory role for CAP37

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

cell chemotaxis

1 reference

8 April 2019

CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

cellular extravasation

1 reference

8 April 2019

Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

inflammatory response

1 reference

8 April 2019

Heparin binding protein (CAP37) differentially modulates endotoxin-induced cytokine production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

calcium-mediated signaling using intracellular calcium source

IGI

1 reference

8 April 2019

Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

IGI

glial cell migration

1 reference

8 April 2019

Activation of microglia: a neuroinflammatory role for CAP37

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

positive regulation of cell adhesion

positive regulation of protein kinase activity

1 reference

8 April 2019

CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20160

1 reference

8 April 2019

serine proteases, trypsin domain

has part(s)

1 reference

http://www.ebi.ac.uk/interpro/protein/P20160

InterPro Release 71.0

reference URL

Identifiers

MeSH descriptor ID

C062991

subject named as

AZU1 protein, human

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

1 reference

20 March 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023