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Wikidata

(Q21118353)

English

fms related receptor tyrosine kinase 4

mammalian protein found in Homo sapiens

  • FLT4
  • VEGF receptor-3
  • vascular endothelial growth factor receptor 3
  • fms-like tyrosine kinase 4
  • tyrosine-protein kinase receptor FLT4
  • primary congenital lymphedema
  • fms related tyrosine kinase 4
  • FLT-4
  • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
In more languages
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No label defined

No description defined

Statements

part of
molecular function
vascular endothelial growth factor-activated receptor activity
determination method or standard
IDA
IEA
IMP
TAS
6 references
retrieved
16 July 2018
stated in
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
TAS
retrieved
16 July 2018
stated in
Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
16 July 2018
stated in
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IEA
retrieved
16 July 2018
stated in
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IDA
protein binding
determination method or standard
IPI
5 references
retrieved
8 April 2019
stated in
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IPI
retrieved
8 April 2019
stated in
The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IPI
retrieved
8 April 2019
stated in
VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IPI
retrieved
8 April 2019
stated in
Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IPI
vascular endothelial growth factor-activated receptor activity
determination method or standard
IBA
IDA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
TAS
retrieved
8 April 2019
stated in
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
8 April 2019
stated in
Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IEA
retrieved
8 April 2019
stated in
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IBA
cell component
biological process
vascular endothelial growth factor receptor signaling pathway
determination method or standard
IDA
IGI
TAS
IMP
IEA
6 references
retrieved
10 September 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
TAS
retrieved
10 September 2018
stated in
Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
10 September 2018
stated in
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
10 September 2018
stated in
Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IGI
retrieved
10 September 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IEA
retrieved
10 September 2018
stated in
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P35916&geneProductId=UniProtKB:P35916
determination method or standard
IDA
positive regulation of cell population proliferation
determination method or standard
IBA
IEA
IGI
IMP
5 references
retrieved
8 April 2019
stated in
Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
8 April 2019
stated in
Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
8 April 2019
stated in
Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IBA
vascular endothelial growth factor receptor signaling pathway
determination method or standard
IBA
IDA
IEA
IGI
IMP
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
TAS
retrieved
8 April 2019
stated in
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
8 April 2019
stated in
Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
GOA
curator
UniProt
UniProt protein ID
P35916
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IMP
retrieved
8 April 2019
stated in
Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IEA
retrieved
8 April 2019
stated in
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35916
determination method or standard
IBA
physically interacts with

Identifiers

MeSH descriptor ID
D040321
subject named as
Vascular Endothelial Growth Factor Receptor-3
0 references
 
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