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Wikidata

(Q21115853)

English

Epithelial cell transforming 2

mammalian protein found in Homo sapiens

  • ECT2
  • epithelial cell-transforming sequence 2 oncogene
  • protein ECT2
In more languages
default for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
17 references
retrieved
31 October 2017
stated in
Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
The armadillo protein p0071 regulates Rho signalling during cytokinesis
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
An ECT2-centralspindlin complex regulates the localization and function of RhoA
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Dissecting the role of Rho-mediated signaling in contractile ring formation
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Plk4 is required for cytokinesis and maintenance of chromosomal stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
retrieved
31 October 2017
stated in
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IPI
cell component
midbody
determination method or standard
IDA
IEA
5 references
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IEA
retrieved
31 October 2017
stated in
Downregulation of cough by exercise and voluntary hyperpnea
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA
retrieved
31 October 2017
stated in
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA
retrieved
31 October 2017
stated in
An ECT2-centralspindlin complex regulates the localization and function of RhoA
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA
retrieved
31 October 2017
stated in
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA
nucleus
determination method or standard
IDA
IEA
8 references
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IEA
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IEA
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IEA
retrieved
31 October 2017
stated in
Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA
retrieved
31 October 2017
stated in
Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA
retrieved
31 October 2017
stated in
An ECT2-centralspindlin complex regulates the localization and function of RhoA
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA
retrieved
31 October 2017
stated in
Downregulation of cough by exercise and voluntary hyperpnea
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA
retrieved
31 October 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA
biological process
positive regulation of cytokinesis
determination method or standard
IDA
IMP
6 references
retrieved
31 October 2017
stated in
Downregulation of cough by exercise and voluntary hyperpnea
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IMP
retrieved
31 October 2017
stated in
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IMP
retrieved
31 October 2017
stated in
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IMP
retrieved
31 October 2017
stated in
An ECT2-centralspindlin complex regulates the localization and function of RhoA
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IMP
retrieved
31 October 2017
stated in
The armadillo protein p0071 regulates Rho signalling during cytokinesis
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IMP
retrieved
31 October 2017
stated in
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis
GOA
curator
UniProt
UniProt protein ID
Q9H8V3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H8V3&geneProductId=UniProtKB:Q9H8V3
determination method or standard
IDA

Identifiers

RefSeq protein ID
 
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