(Q21115359)

http://www.ebi.ac.uk/interpro/protein/Q96D31

Transporter Classification Database ID

1.A.52.1.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

Orai superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96D31

1 reference

13 November 2019

1 reference

13 November 2019

store-operated calcium channel activity

6 references

31 October 2017

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Orai1 and STIM reconstitute store-operated calcium channel function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

calcium channel activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

1 reference

31 October 2017

calmodulin binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

1 reference

31 October 2017

protein binding

19 references

31 October 2017

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Orai proteins interact with TRPC channels and confer responsiveness to store depletion.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Store-independent activation of Orai1 by SPCA2 in mammary tumors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

identical protein binding

5 references

31 October 2017

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Structural determinants of ion permeation in CRAC channels

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Pore architecture of the ORAI1 store-operated calcium channel.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Functional stoichiometry of the unitary calcium-release-activated calcium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

1 reference

31 October 2017

integral component of plasma membrane

regulation of calcium ion transport

biological process

IMP

1 reference

31 October 2017

Orai1 is an essential pore subunit of the CRAC channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

IMP

adaptive immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

1 reference

31 October 2017

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

1 reference

31 October 2017

ion transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

1 reference

31 October 2017

calcium ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

1 reference

31 October 2017

calcium ion transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

1 reference

31 October 2017

positive regulation of calcium ion transport

4 references

31 October 2017

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Orai1 and STIM reconstitute store-operated calcium channel function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

31 October 2017

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96D31&geneProductId=UniProtKB:Q96D31

1 reference

31 October 2017

D12.776.157.530.400.150.740.500

Identifiers

MeSH descriptor ID

D000071740

subject named as

ORAI1 Protein

0 references

MeSH tree code

0 references

D12.776.543.550.450.150.740.500

0 references

D12.776.543.585.400.150.740.500

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

4 August 2016

language of work or name

1 reference

4 August 2016

language of work or name

English

Transporter Classification Database ID

1.A.52.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023