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Wikidata

(Q21107568)

English

TLE family member 1, transcriptional corepressor

mammalian protein found in Homo sapiens

  • TLE1
  • E(Sp1) homolog
  • transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
  • transducin like enhancer of split 1
  • ESG1
  • transducin-like enhancer protein 1
  • enhancer of split groucho-like protein 1
  • TLE1 protein, human
  • Transducin-like enhancer protein 1
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
8 references
retrieved
8 April 2019
stated in
Six3 and Six6 activity is modulated by members of the groucho family
GOA
curator
UniProt
UniProt protein ID
Q04724
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
GOA
curator
UniProt
UniProt protein ID
Q04724
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IPI
retrieved
8 April 2019
stated in
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IPI
retrieved
8 April 2019
stated in
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IPI
retrieved
8 April 2019
stated in
TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular functions of the TLE tetramerization domain in Wnt target gene repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IPI
cell component
nucleus
determination method or standard
IBA
IDA
IEA
IMP
TAS
6 references
retrieved
8 April 2019
stated in
Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
TAS
retrieved
8 April 2019
stated in
TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells
GOA
curator
UniProt
UniProt protein ID
Q04724
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q04724
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IEA
retrieved
8 April 2019
stated in
Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724
determination method or standard
IBA
biological process

Identifiers

MeSH descriptor ID
C499043
subject named as
TLE1 protein, human
0 references
RefSeq protein ID
NP_005068
1 reference
stated in
NCBI Gene
retrieved
22 November 2019
Entrez Gene ID
7088
 
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