(Q15708271)

English

obeticholic acid

chemical compound

6-ECDCA
6-Et CDCA
6-ethylchenodeoxycholic acid
INT-747
OCA
Ocaliva®
Obeticholic acid
6-Ethyl-CDCA
6α-ethylchenodeoxycholic acid
6alpha-Ethyl-chenodeoxycholic acid

In more languages

default for all languages

No label defined

No description defined

Statements

type of chemical entity

0 references

chemical compound

0 references

0 references

chemical structure

Obeticholic acid.svg
512 × 305; 6 KB

0 references

420.324 dalton

1 reference

language of work or name

Obeticholic acid (English)

18 November 2016

chemical formula

C₂₆H₄₄O₄

1 reference

language of work or name

Obeticholic acid (English)

18 November 2016

canonical SMILES

CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O

1 reference

language of work or name

Obeticholic acid (English)

18 November 2016

isomeric SMILES

CC[C@@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3[C@@H]1O)CC[C@@H]4[C@H](C)CCC(=O)O)C)C)O

1 reference

language of work or name

Obeticholic acid (English)

18 November 2016

defined daily dose

10 milligram

route of administration

oral administration

1 reference

https://www.whocc.no/atc_ddd_index/?code=A05AA04

determination method or standard

Evidence & Conclusion Ontology ID

2 references

Therapeutic effects of obeticholic acid (OCA) treatment in a bleomycin-induced pulmonary fibrosis rat model

type of reference

Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases.

active ingredient in

1 reference

14 February 2018

World Health Organisation international non-proprietary name

acidum obeticholicum (Latin)

2 references

inventory number

9084

5 November 2015

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9084

Proposed international nonproprietary names: list 101

130

obeticholic acid (English)

2 references

inventory number

9084

5 November 2015

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9084

Proposed international nonproprietary names: list 101

130

acide obéticholique (French)

2 references

inventory number

9084

5 November 2015

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9084

Proposed international nonproprietary names: list 101

130

ácido obeticólico (Spanish)

2 references

inventory number

9084

5 November 2015

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9084

Proposed international nonproprietary names: list 101

130

обетихолевая кислота (Russian)

1 reference

inventory number

9084

5 November 2015

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9084

حمض أسيتوم أوبيتيكوليك (Arabic)

1 reference

inventory number

9084

5 November 2015

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9084

奥贝胆酸 (Chinese)

1 reference

inventory number

9084

5 November 2015

https://mednet-communities.net/inn/db/ViewINN.aspx?i=9084

medical condition treated

ascending cholangitis

1 reference

Drug Indications Extracted from FAERS

2 October 2018

liver cirrhosis

1 reference

Drug Indications Extracted from FAERS

2 October 2018

primary biliary cholangitis

1 reference

Drug Indications Extracted from FAERS

2 October 2018

physically interacts with

Nuclear receptor subfamily 1 group H member 4

subject has role

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

legal status (medicine)

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

LiverTox likelihood score

LiverTox toxicity likelihood category B

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/ObeticholicAcid

10 December 2019

Identifiers

InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1

1 reference

language of work or name

Obeticholic acid (English)

18 November 2016

ZXERDUOLZKYMJM-ZWECCWDJSA-N

2 references

language of work or name

Obeticholic acid (English)

18 November 2016

ChEBI release 2020-09-01

CAS Registry Number

2 references

Global Substance Registration System

language of work or name

obeticholic acid (English)

18 November 2016

ZXERDUOLZKYMJM-ZWECCWDJSA-N

CAS Common Chemistry

9 April 2021

https://commonchemistry.cas.org/detail?cas_rn=459789-99-2

1 reference

language of work or name

Obeticholic acid (English)

18 November 2016

2 references

language of work or name

Obeticholic acid (English)

18 November 2016

matched by identifier from

ZXERDUOLZKYMJM-ZWECCWDJSA-N

no value

0 references

mapping relation type

2 references

ChEBI release 2019-10-02

matched by identifier from

International Chemical Identifier

InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1

1 reference

language of work or name

OBETICHOLIC ACID (English)

18 November 2016

2 references

based on heuristic

inferred from InChIKey

matched by identifier from

ZXERDUOLZKYMJM-ZWECCWDJSA-N

UniChem compound ID

1 reference

DSSTox substance ID

2 references

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

matched by identifier from

ZXERDUOLZKYMJM-ZWECCWDJSA-N

DSSTOX compound identifier

0 references

ObeticholicAcid

0 references

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

(4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (English)

CAS no.: 459789-99-2 (English)

ECHA Substance Infocard ID

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

(4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (English)

CAS no.: 459789-99-2 (English)

0 references

Guide to Pharmacology Ligand ID

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

obeticholic acid (English)

18 November 2016

MeSH descriptor ID

subject named as

obeticholic acid

0 references

1 reference

Global Substance Registration System

language of work or name

obeticholic acid (English)

18 November 2016

1 reference

matched by identifier from

ZXERDUOLZKYMJM-ZWECCWDJSA-N

2 references

Global Substance Registration System

language of work or name

obeticholic acid (English)

18 November 2016

matched by identifier from

ZXERDUOLZKYMJM-ZWECCWDJSA-N

MedlinePlus drug identifier

0 references

1 reference

26 February 2018

Probes And Drugs ID

0 references

1 reference

1 reference

imported from Wikimedia project

English Wikipedia

0 references

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

Protein Data Bank

PDB structure ID

language of work or name

1OSV (English)

19 October 2016

1 reference

Protein Data Bank

PDB structure ID

language of work or name

1OT7 (English)

19 October 2016

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

WikiProjectMed ID

Obeticholic acid

0 references

Sitelinks

Wikipedia(8 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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