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Wikidata

(Q14914032)

English

Myosin VIIA

mammalian protein found in Mus musculus

  • myosin-VIIa
  • Myo7a
  • motor protein
  • shaker 1
  • uniprot:P97479
  • unconventional myosin-VIIa
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No label defined

No description defined

Statements

part of
molecular function
protein binding
determination method or standard
IPI
11 references
retrieved
14 February 2019
stated in
PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa
GOA
curator
UniProt
UniProt protein ID
P97479
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
PDZD7-MYO7A complex identified in enriched stereocilia membranes.
GOA
curator
UniProt
UniProt protein ID
P97479
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly
GOA
curator
UniProt
UniProt protein ID
P97479
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
Interactions in the network of Usher syndrome type 1 proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
Interactions in the network of Usher syndrome type 1 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
retrieved
14 February 2019
stated in
The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IPI
cell component
cytoplasm
determination method or standard
IDA
IEA
ISO
14 references
retrieved
14 February 2019
stated in
The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
ISO
retrieved
14 February 2019
stated in
Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97479
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IEA
retrieved
14 February 2019
stated in
Hes1 is a negative regulator of inner ear hair cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
Interactions in the network of Usher syndrome type 1 proteins
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
The small GTPase Rac1 regulates auditory hair cell morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
stereocilium
determination method or standard
EXP
IDA
5 references
retrieved
14 February 2019
stated in
PDZD7-MYO7A complex identified in enriched stereocilia membranes.
GOA
curator
UniProt
UniProt protein ID
P97479
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
The small GTPase Rac1 regulates auditory hair cell morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IDA
retrieved
14 February 2019
stated in
Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
EXP
biological process
hearing
determination method or standard
ISS
IEA
IMP
ISO
13 references
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97479
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
ISS
retrieved
14 February 2019
stated in
Defective myosin VIIA gene responsible for Usher syndrome type 1B
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
ISO
retrieved
14 February 2019
stated in
Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IMP
retrieved
14 February 2019
stated in
A type VII myosin encoded by the mouse deafness gene shaker-1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IMP
retrieved
14 February 2019
stated in
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IMP
retrieved
14 February 2019
stated in
The pattern of sensorineural degeneration in the cochlea of the deaf shaker-1 mouse: ultrastructural observations
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IMP
retrieved
14 February 2019
stated in
Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IMP
retrieved
14 February 2019
stated in
HEARING DEGENERATION IN SHAKER-1 MOUSE. CORRELATION OF PHYSIOLOGICAL OBSERVATIONS WITH BEHAVIORAL RESPONSES AND WITH COCHLEAR ANATOMY
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IMP
retrieved
14 February 2019
stated in
A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IMP
retrieved
14 February 2019
stated in
Mutation analysis of the mouse myosin VIIA deafness gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IMP
retrieved
14 February 2019
stated in
The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P97479
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97479
determination method or standard
IEA

Identifiers

 
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