(Q14905130)

IPI

1 reference

14 February 2019

Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

IPI

protein binding

integral component of membrane

IPI

cell component

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

membrane

2 references

autophagosome

1 reference

14 February 2019

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

lysosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

lysosome

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

24 April 2018

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

cytoplasmic vesicle

1 reference

14 February 2019

Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

Golgi apparatus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

endosome

lysosome

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

14 February 2019

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

negative regulation of neuron apoptotic process

biological process

1 reference

14 February 2019

Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

negative regulation of proteolysis

1 reference

14 February 2019

Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

regulation of filopodium assembly

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

protein localization to membrane

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

positive regulation of protein phosphorylation

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

endocytosis

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

associative learning

1 reference

14 February 2019

Behavioral assessment in mouse models of neuronal ceroid lipofuscinosis using a light-cued T-maze

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

negative regulation of catalytic activity

1 reference

14 February 2019

Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

regulation of cytosolic calcium ion concentration

1 reference

14 February 2019

Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

neuromuscular process controlling balance

1 reference

14 February 2019

Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

cellular amino acid metabolic process

1 reference

14 February 2019

Altered amino acid levels in sera of a mouse model for juvenile neuronal ceroid lipofuscinoses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

neurotransmitter metabolic process

1 reference

14 February 2019

High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

protein processing

1 reference

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

autophagosome maturation

1 reference

14 February 2019

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

ionotropic glutamate receptor signaling pathway

1 reference

14 February 2019

Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

regulation of gene expression

1 reference

14 February 2019

Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

action potential

1 reference

14 February 2019

Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

membrane organization

1 reference

14 February 2019

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

protein localization to plasma membrane

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

lysosome organization

4 references

24 April 2018

A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

A murine model for juvenile NCL: gene targeting of mouse Cln3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

24 April 2018

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

cell migration

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

macroautophagy

1 reference

14 February 2019

Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

amino acid transport

1 reference

14 February 2019

Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

actin cytoskeleton organization

1 reference

14 February 2019

CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

vacuolar transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61124&geneProductId=UniProtKB:Q61124

1 reference

24 April 2018

lysosomal lumen acidification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

lysosome organization

Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

A mouse gene knockout model for juvenile ceroid-lipofuscinosis (Batten disease)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

A murine model for juvenile NCL: gene targeting of mouse Cln3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

regulation of intracellular pH

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61124

Transporter Classification Database ID

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

2.A.57.5.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database