(Q14904355)

Dwarfin

1 reference

SMAD MH1 domain superfamily

1 reference

SMAD/FHA domain superfamily

1 reference

MAD homology, MH1, protein family

1 reference

based on heuristic

inferred from protein domain or family

SMAD domain, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

MAD homology 1, Dwarfin-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

1 reference

14 February 2019

DNA-binding transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

1 reference

14 February 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

1 reference

14 February 2019

protein binding

3 references

14 February 2019

Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

14 February 2019

Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

14 February 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

DNA-binding transcription repressor activity, RNA polymerase II-specific

Norwegian University of Science and Technology, Systems Biology team

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

transcription regulator complex

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

1 reference

14 February 2019

intracellular anatomical structure

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97454&geneProductId=UniProtKB:P97454

1 reference

24 April 2018

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

5 references

14 February 2019

14 February 2019

Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

14 February 2019

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

14 February 2019

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

14 February 2019

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

3 references

14 February 2019

14 February 2019

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

14 February 2019

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

biological process

germ cell development

1 reference

14 February 2019

Smad5 is required for mouse primordial germ cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

1 reference

14 February 2019

ureteric bud development

IEP

1 reference

14 February 2019

Smad expression during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

regulation of transcription, DNA-templated

IEP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

1 reference

14 February 2019

cardiac muscle contraction

1 reference

14 February 2019

Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

SMAD protein signal transduction

1 reference

14 February 2019

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

embryonic pattern specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

1 reference

14 February 2019

ISS

ossification

Ensembl genome database project

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

cellular response to organic cyclic compound

1 reference

14 February 2019

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

BMP signaling pathway

Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

TAS

14 February 2019

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

14 February 2019

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

14 February 2019

The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

14 February 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97454&geneProductId=UniProtKB:P97454

1 reference

24 April 2018

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

1 reference

14 February 2019

protein phosphorylation

1 reference

14 February 2019

Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

cartilage development

1 reference

14 February 2019

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

positive regulation of osteoblast differentiation

1 reference

14 February 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

1 reference

14 February 2019

erythrocyte differentiation

1 reference

14 February 2019

BMP4 and Madh5 regulate the erythroid response to acute anemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

bone development

1 reference

14 February 2019

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

1 reference

14 February 2019

The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

osteoblast fate commitment

1 reference

14 February 2019

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

cellular response to BMP stimulus

1 reference

14 February 2019

The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors.

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97454

MAD homology 1, Dwarfin-type

has part(s)

1 reference

MAD homology, MH1

1 reference

SMAD domain, Dwarfin-type

1 reference