(Q14903156)

English

Bone morphogenetic protein 2

mammalian protein found in Mus musculus

bone morphogenetic protein 2
Bmp2
BMP-2A
bone morphogenetic protein 2A

In more languages

default for all languages

No label defined

No description defined

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Transforming growth factor-beta-related

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21274

Cystine-knot cytokine

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21274

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transforming growth factor beta receptor binding

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

BMP receptor binding

determination method or standard

3 references

8 April 2019

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

protein binding

determination method or standard

8 references

8 April 2019

WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

NAD-retinol dehydrogenase activity

determination method or standard

1 reference

8 April 2019

RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

signaling receptor binding

determination method or standard

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

growth factor activity

determination method or standard

protein domain specific binding

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

protein homodimerization activity

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

cytokine activity

determination method or standard

3 references

8 April 2019

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

extracellular region

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

extracellular space

determination method or standard

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

protein-containing complex

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

extracellular space

determination method or standard

5 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

biological process

positive regulation of Wnt signaling pathway by BMP signaling pathway

determination method or standard

1 reference

8 April 2019

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

mesenchyme development

determination method or standard

odontogenesis of dentin-containing tooth

determination method or standard

1 reference

8 April 2019

Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

telencephalon regionalization

determination method or standard

1 reference

8 April 2019

Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

atrioventricular valve morphogenesis

determination method or standard

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

proteoglycan metabolic process

determination method or standard

1 reference

8 April 2019

Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

mesenchymal cell differentiation

determination method or standard

pericardium development

determination method or standard

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of ERK1 and ERK2 cascade

determination method or standard

animal organ morphogenesis

determination method or standard

1 reference

8 April 2019

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

inner ear development

determination method or standard

1 reference

8 April 2019

Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

transforming growth factor beta receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

negative regulation of canonical Wnt signaling pathway

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

negative regulation of cell population proliferation

determination method or standard

3 references

8 April 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

regulation of apoptotic process

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

cell fate commitment

determination method or standard

1 reference

8 April 2019

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

regulation of MAPK cascade

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

SMAD protein signal transduction

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

cardiac muscle cell differentiation

determination method or standard

4 references

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

in utero embryonic development

determination method or standard

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

mesenchymal cell proliferation involved in ureteric bud development

determination method or standard

1 reference

8 April 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

regulation of odontogenesis of dentin-containing tooth

determination method or standard

1 reference

8 April 2019

Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of Wnt signaling pathway

determination method or standard

1 reference

8 April 2019

Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

heart development

determination method or standard

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

branching involved in ureteric bud morphogenesis

determination method or standard

1 reference

8 April 2019

Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

cartilage development

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of cartilage development

determination method or standard

3 references

8 April 2019

Novel regulators of bone formation: molecular clones and activities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of neuron differentiation

determination method or standard

1 reference

8 April 2019

Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of cell differentiation

determination method or standard

1 reference

8 April 2019

Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

thyroid-stimulating hormone-secreting cell differentiation

determination method or standard

1 reference

8 April 2019

Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

inflammatory response

determination method or standard

1 reference

8 April 2019

Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of fat cell differentiation

determination method or standard

1 reference

8 April 2019

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of pri-miRNA transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

Notch signaling pathway

determination method or standard

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

bone mineralization

determination method or standard

3 references

8 April 2019

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

cell differentiation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

corticotropin hormone secreting cell differentiation

determination method or standard

1 reference

8 April 2019

Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of astrocyte differentiation

determination method or standard

3 references

8 April 2019

Id4 is required for the correct timing of neural differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Astrocyte differentiation mediated by LIF in cooperation with BMP2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Id4 is required for the correct timing of neural differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

cellular response to organic cyclic compound

determination method or standard

1 reference

8 April 2019

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of ossification

determination method or standard

4 references

8 April 2019

Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

4 references

24 April 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of epithelial to mesenchymal transition

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

BMP signaling pathway

determination method or standard

8 references

24 April 2018

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

24 April 2018

Akt promotes BMP2-mediated osteoblast differentiation and bone development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21274&geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of neurogenesis

determination method or standard

1 reference

8 April 2019

Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of osteoblast differentiation

determination method or standard

5 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

embryonic heart tube anterior/posterior pattern specification

determination method or standard

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

osteoblast differentiation

determination method or standard

8 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Akt promotes BMP2-mediated osteoblast differentiation and bone development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Akt promotes BMP2-mediated osteoblast differentiation and bone development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of odontogenesis

determination method or standard

1 reference

8 April 2019

Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of osteoblast proliferation

determination method or standard

1 reference

8 April 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

response to hypoxia

determination method or standard

1 reference

8 April 2019

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of cell migration

determination method or standard

1 reference

8 April 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

cellular response to growth factor stimulus

determination method or standard

1 reference

8 April 2019

Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method or standard

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

cardiac muscle tissue morphogenesis

determination method or standard

1 reference

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

endocardial cushion morphogenesis

determination method or standard

multicellular organism development

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of gene expression

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

10 references

8 April 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Molecular mechanisms of cell and tissue interactions during early tooth development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Bone morphogenetic proteins (BMP-2 and BMP-3) induce the late phase expression of the proto-oncogene c-fos in murine osteoblastic MC3T3-E1 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

negative regulation of gene expression

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

5 references

8 April 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

response to bacterium

determination method or standard

1 reference

8 April 2019

Impact of lactobacilli on orally acquired listeriosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

BMP signaling pathway

determination method or standard

9 references

8 April 2019

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Akt promotes BMP2-mediated osteoblast differentiation and bone development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

cell development

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

positive regulation of bone mineralization

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

8 April 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21274

determination method or standard

Transforming growth factor beta, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21274

TGF-beta, propeptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21274

Transforming growth factor-beta, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21274

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000028836

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000028836

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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