(Q14866122)

English

Fas ligand (TNF superfamily, member 6)

mammalian protein found in Mus musculus

Fasl
tumor necrosis factor ligand superfamily member 6
generalized lymphoproliferative disease
tumor necrosis factor ligand 1a
Fas ligand
Fas antigen ligand
CD95 ligand
CD95-L

In more languages

default for all languages

No label defined

No description defined

Statements

1 reference

25 May 2022

UniProt protein ID

tumor necrosis factor ligand superfamily member 6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41047

Tumour necrosis factor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41047

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Tumour necrosis factor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

cytokine activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

tumor necrosis factor receptor binding

determination method or standard

protein binding

determination method or standard

1 reference

5 June 2018

Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41047&geneProductId=UniProtKB:P41047

determination method or standard

extracellular region

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

lysosomal lumen

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

integral component of membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

determination method or standard

1 reference

9 May 2019

MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

cytoplasmic vesicle lumen

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

9 May 2019

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

plasma membrane

determination method or standard

determination method or standard

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

extracellular space

determination method or standard

cytoplasmic vesicle

determination method or standard

biological process

response to growth factor

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41047&geneProductId=UniProtKB:P41047

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

retinal cell programmed cell death

determination method or standard

1 reference

9 May 2019

Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41047&geneProductId=UniProtKB:P41047

determination method or standard

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

immune response

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

apoptotic signaling pathway

determination method or standard

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

4 references

14 February 2019

Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

14 February 2019

The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

14 February 2019

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

5 references

9 May 2019

Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41047

determination method or standard

Tumour necrosis factor, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41047

Tumour necrosis factor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41047

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000000834

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000000834

ENSMUSP00000141422

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000141422

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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