(Q14866180)

http://www.ebi.ac.uk/interpro/protein/P09038

fibroblast growth factor 2

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09038

Transporter Classification Database ID

1.A.108.1.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

heparin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

fibroblast growth factor receptor binding

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

protein binding

15 references

8 April 2019

Translokin is an intracellular mediator of FGF-2 trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Structural basis for FGF receptor dimerization and activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Klotho converts canonical FGF receptor into a specific receptor for FGF23

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Active caspase-1 is a regulator of unconventional protein secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Long pentraxin 3/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Fibroblast growth factor-2 interacts with free ribosomal protein S19

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

nuclear receptor coactivator activity

1 reference

8 April 2019

Regulation of secreted Frizzled-related protein-1 by heparin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

chemoattractant activity

1 reference

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

growth factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09038&geneProductId=UniProtKB:P09038

1 reference

1 January 2018

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09038&geneProductId=UniProtKB:P09038

1 reference

1 January 2018

1-phosphatidylinositol-3-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09038&geneProductId=UniProtKB:P09038

1 reference

1 January 2018

receptor-receptor interaction

1 reference

8 April 2019

Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

integrin binding

1 reference

8 April 2019

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

cell component

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

4 references

8 April 2019

8 April 2019

Structural basis for FGF receptor dimerization and activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

release of sequestered calcium ion into cytosol

biological process

1 reference

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

negative regulation of fibroblast migration

1 reference

8 April 2019

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

hyaluronan catabolic process

1 reference

8 April 2019

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of endothelial cell proliferation

positive regulation of MAP kinase activity

1 reference

8 April 2019

Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

negative regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

1 reference

8 April 2019

Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

somatic stem cell population maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

positive regulation of phospholipase C activity

1 reference

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

extracellular matrix organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

wound healing

negative regulation of cell death

2 references

1 reference

8 April 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

regulation of angiogenesis

1 reference

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

nervous system development

1 reference

8 April 2019

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

cell migration involved in sprouting angiogenesis

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

positive regulation of angiogenesis

positive regulation of phosphatidylinositol 3-kinase activity

1 reference

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

Regulation of secreted Frizzled-related protein-1 by heparin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

chemotaxis

1 reference

8 April 2019

Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

fibroblast growth factor receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

7 references

8 April 2019

8 April 2019

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

8 April 2019

Regulation of secreted Frizzled-related protein-1 by heparin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

chondroblast differentiation

1 reference

8 April 2019

Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEK-ERK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

growth factor dependent regulation of skeletal muscle satellite cell proliferation

1 reference

8 April 2019

The role of syndecan-4 and attached glycosaminoglycan chains on myogenic satellite cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

branching involved in ureteric bud morphogenesis

1 reference

8 April 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of cardiac muscle cell proliferation

1 reference

8 April 2019

Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

embryonic morphogenesis

1 reference

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

positive regulation of cell fate specification

1 reference

8 April 2019

Crucial role of vHNF1 in vertebrate hepatic specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

animal organ morphogenesis

1 reference

8 April 2019

Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

regulation of endothelial cell chemotaxis to fibroblast growth factor

1 reference

8 April 2019

Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

phosphatidylinositol biosynthetic process

1 reference

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

inositol phosphate biosynthetic process

1 reference

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

negative regulation of wound healing

1 reference

8 April 2019

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

Ras protein signal transduction

1 reference

8 April 2019

Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

signal transduction

1 reference

8 April 2019

Nerve growth factor regulation of m4 muscarinic receptor mRNA stability but not gene transcription requires mitogen-activated protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

phosphatidylinositol phosphate biosynthetic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09038&geneProductId=UniProtKB:P09038

peptidyl-tyrosine phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09038&geneProductId=UniProtKB:P09038

positive regulation of sprouting angiogenesis

positive regulation of cell population proliferation

Cloning and expression of cDNA encoding human basic fibroblast growth factor

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

phosphatidylinositol-3-phosphate biosynthetic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09038&geneProductId=UniProtKB:P09038

stem cell proliferation

1 reference

8 April 2019

Functional consequences of 17q21.31/WNT3-WNT9B amplification in hPSCs with respect to neural differentiation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

regulation of signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of protein kinase B signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

positive regulation of blood vessel endothelial cell migration

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEK-ERK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of vascular associated smooth muscle cell proliferation

1 reference

8 April 2019

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of vascular endothelial cell proliferation

1 reference

8 April 2019

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of cell migration involved in sprouting angiogenesis

1 reference

8 April 2019

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

paracrine signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

1 reference

8 April 2019

positive regulation of angiogenesis

ISS

The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

positive regulation of DNA biosynthetic process

positive regulation of endothelial cell chemotaxis

1 reference

8 April 2019

The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09038

Gene Atlas image

PBB GE FGF2 204422 s at fs.png
732 × 530; 10 KB

0 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

1.A.108.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database