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Kinase inhibition in autoimmunity and inflammation
scientific article published on 19 October 2020
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1 reference
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
review article
1 reference
stated in
PubMed
retrieved
24 June 2021
title
Kinase inhibition in autoimmunity and inflammation
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
main subject
autoimmunity
1 reference
stated in
PubMed
retrieved
24 June 2021
author
Ali A Zarrin
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
Katherine Bao
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
author name string
Patrick Lupardus
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
Domagoj Vucic
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
publication date
19 October 2020
1 reference
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
1 January 2021
1 reference
stated in
PubMed Central
retrieved
24 June 2021
published in
Nature Reviews Drug Discovery
2 references
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
stated in
PubMed Central
retrieved
24 June 2021
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JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
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The Other Function: Class II-Restricted Antigen Presentation by B Cells
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Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens
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1 reference
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7 January 2021
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7 January 2021
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1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
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1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct molecular mechanism for initiating TRAF6 signalling
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK-M is a negative regulator of Toll-like receptor signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interleukin-1 receptor-associated kinase M selectively inhibits the alternative, instead of the classical NFkappaB pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
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inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
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inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficiency in IRAK4 activity attenuates manifestations of murine Lupus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The diverse role of RIP kinases in necroptosis and inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RIPK1 and RIPK3: critical regulators of inflammation and cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular regulation of TNF activity in health and disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RIP3 induces apoptosis independent of pronecrotic kinase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RIP1 kinase activity is critical for skin inflammation but not for viral propagation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IL-13-induced airway mucus production is attenuated by MAPK13 inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting RIPK1 for the treatment of human diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NOD1 and NOD2: signaling, host defense, and inflammatory disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autoinflammatory granulomatous diseases: from Blau syndrome and early-onset sarcoidosis to NOD2-mediated disease and Crohn's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TEC-family kinases: regulators of T-helper-cell differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of BTK and ITK: state of the new drugs for cancer, autoimmunity and inflammatory diseases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tec family kinases modulate thresholds for thymocyte development and selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis by death factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ibrutinib treatment improves T cell number and function in CLL patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective B cell development and function in Btk-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Type I and III Interferon Productions Are Impaired in X-Linked Agammaglobulinemia Patients Toward Poliovirus but Not Influenza Virus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fcgamma receptors as regulators of immune responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BTK inhibition is a potent approach to block IgE-mediated histamine release in human basophils
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton's Tyrosine Kinase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Btk inhibition treats TLR7/IFN driven murine lupus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The BTK-inhibitor ibrutinib may protect against pulmonary injury in COVID-19 infected patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The SYK tyrosine kinase: a crucial player in diverse biological functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural and biophysical characterization of the Syk activation switch
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Getting Syk: spleen tyrosine kinase as a therapeutic target.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Syk tyrosine kinase required for mouse viability and B-cell development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study of 2 dosing regimens of fostamatinib in patients with rheumatoid arthritis with an inadequate response to a tumor necrosis factor-α antagonist
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fostamatinib, an oral spleen tyrosine kinase inhibitor, in the treatment of rheumatoid arthritis: a meta-analysis of randomized controlled trials
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fostamatinib: First Global Approval.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fostamatinib for persistent/chronic adult immune thrombocytopenia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase 2 study of idelalisib and entospletinib: pneumonitis limits combination therapy in relapsed refractory CLL and NHL.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TPL2 kinase action and control of inflammation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p38 MAP-kinases pathway regulation, function and role in human diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential activation of p38MAPK isoforms by MKK6 and MKK3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TPL2 meets p38MAPK: emergence of a novel positive feedback loop in inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alternative p38 MAPKs are essential for collagen-induced arthritis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role of p38gamma in K-Ras transformation independent of phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p38 Mitogen-activated protein kinase inhibitors: a review on pharmacophore mapping and QSAR studies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p38(MAPK): stress responses from molecular mechanisms to therapeutics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and -γ selectivity, suppresses COPD inflammation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A controlled clinical trial with pirfenidone in the treatment of pathological skin scarring caused by burns in pediatric patients.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pirfenidone in the treatment of idiopathic pulmonary fibrosis: an evidence-based review of its place in therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An Open-label, Phase II Study of the Safety and Tolerability of Pirfenidone in Patients with Scleroderma-associated Interstitial Lung Disease: the LOTUSS Trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pirfenidone gel in patients with localized scleroderma: a phase II study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pirfenidone for diabetic nephropathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERK5: structure, regulation and function.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recent advances in colony stimulating factor-1 receptor/c-FMS as an emerging target for various therapeutic implications.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERK5 kinase activity is dispensable for cellular immune response and proliferation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ERK5 is a critical mediator of inflammation-driven cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of type-I- and type-II-interferon-mediated signalling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic interferonopathies: An overview
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Type I interferonopathies in pediatric rheumatology
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human TBK1: A Gatekeeper of Neuroinflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitin-specific protease 2b negatively regulates IFN-β production and antiviral activity by targeting TANK-binding kinase 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle, CDKs and cancer: a changing paradigm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of Cdk8/Cdk19 Activity Promotes Treg Cell Differentiation and Suppresses Autoimmune Diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Turning the Tide Against Regulatory T Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Artificial intelligence in drug discovery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific delivery of kinase inhibitors in nonmalignant and malignant diseases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation and function of NF-kappaB transcription factors in the immune system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Innate immune recognition of DNA: A recent history
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41573-020-0082-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/S41573-020-0082-8
1 reference
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
PMC publication ID
7569567
0 references
PubMed publication ID
33077936
1 reference
stated in
Europe PubMed Central
PubMed publication ID
33077936
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33077936%20AND%20SRC:MED&resulttype=core&format=json
retrieved
23 October 2020
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