(Q82860891)

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Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation

scientific article published on 17 March 2006

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Europe PubMed Central

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18 January 2020

Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation (English)

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18 January 2020

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5

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18 January 2020

7

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18 January 2020

12

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18 January 2020

14

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18 January 2020

author name string

González-Santiago L

1

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18 January 2020

Suárez Y

2

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18 January 2020

Zarich N

3

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18 January 2020

Muñoz-Alonso MJ

4

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18 January 2020

Martínez T

6

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18 January 2020

Iradi A

8

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18 January 2020

Sáez-Tormo G

9

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18 January 2020

Maier JV

10

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18 January 2020

Moorthy A

11

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18 January 2020

Rojas JM

13

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18 January 2020

publication date

17 March 2006

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18 January 2020

Cell Death & Differentiation

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18 January 2020

13

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18 January 2020

11

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18 January 2020

1968-1981

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18 January 2020

Structure--activity relationships of the didemnins.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

JNK activation is critical for Aplidin-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Antiangiogenic activity of aplidine, a new agent of marine origin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of Aplidin in acute lymphoblastic leukaemia cells.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Toxicity of glutathione depletion in mesencephalic cultures: a role for arachidonic acid and its lipoxygenase metabolites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of JNK signaling by GSTp

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Glutathione: toxicological implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Non-oxidative loss of glutathione in apoptosis via GSH extrusion.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Rescue of cells from apoptosis by inhibition of active GSH extrusion.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure and regulation of MAPK phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Prologation of c-Jun N-terminal kinase is associated with cell death induced by tumor necrosis factor alpha in human chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficiency of homocysteine plus copper in inducing apoptosis is inversely proportional to gamma-glutamyl transpeptidase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxytosis: A novel form of programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401898

7 January 2021

based on heuristic

inferred from DOI database lookup

The regulation of reactive oxygen species production during programmed cell death

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide

1 reference

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7 January 2021

based on heuristic

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Blood glutathione as an index of radiation-induced oxidative stress in mice and humans

1 reference

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7 January 2021

based on heuristic

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A fluorometric method for determination of oxidized and reduced glutathione in tissues

1 reference

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HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain

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Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1

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Identifiers

10.1038/SJ.CDD.4401898

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16543941%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

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18 January 2020

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