(Q81768343)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18694378%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

review article

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title

NF-kappaB in carcinoma therapy and prevention (English)

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12 January 2020

1 reference

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12 January 2020

Jonah Cohen

1 reference

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12 January 2020

Pattatheyil Arun

series ordinal

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12 January 2020

Zhong Chen

series ordinal

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12 January 2020

Carter Van Waes

series ordinal

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12 January 2020

publication date

1 September 2008

1 reference

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Expert Opinion on Therapeutic Targets

12 January 2020

published in

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12 January 2020

volume

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12 January 2020

issue

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12 January 2020

page(s)

1109-1122

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18694378%20AND%20SRC:MED&resulttype=core&format=json

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

12 January 2020

cites work

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12 December 2020

Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

1 reference

12 December 2020

Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2.

1 reference

12 December 2020

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

1 reference

12 December 2020

Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model.

1 reference

12 December 2020

Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis

1 reference

12 December 2020

Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma.

1 reference

12 December 2020

Nuclear factor-kappa B and cancer: its role in prevention and therapy

1 reference

12 December 2020

Sulindac enhances tumor necrosis factor-alpha-mediated apoptosis of lung cancer cell lines by inhibition of nuclear factor-kappaB.

1 reference

12 December 2020

The evolution of thalidomide and its IMiD derivatives as anticancer agents

1 reference

12 December 2020

Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma

1 reference

12 December 2020

Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

1 reference

12 December 2020

Hostile takeovers: viral appropriation of the NF-kB pathway

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12 December 2020

Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta

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12 December 2020

MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo

1 reference

12 December 2020

Inhibition of CK2 activity provokes different responses in hormone-sensitive and hormone-refractory prostate cancer cells

1 reference

12 December 2020

Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-kappaB and other signal transcription factors in head and neck squamous cell carcinoma.

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12 December 2020

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

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12 December 2020

Circuitry of nuclear factor kappaB signaling

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12 December 2020

The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells

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12 December 2020

Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis

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12 December 2020

PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer

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12 December 2020

Targeting CK2 for cancer therapy

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12 December 2020

Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines

1 reference

12 December 2020

Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis

1 reference

12 December 2020

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

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12 December 2020

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

1 reference

12 December 2020

Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells

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12 December 2020

Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study

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12 December 2020

Apigenin and cancer chemoprevention: progress, potential and promise (review).

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12 December 2020

Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2

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12 December 2020

Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation

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12 December 2020

A prospective study of aspirin use and the risk for colorectal adenoma

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12 December 2020

Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts

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12 December 2020

Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence

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12 December 2020

Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth

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12 December 2020

Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma

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12 December 2020

Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity

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12 December 2020

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

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12 December 2020

A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response

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12 December 2020

Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells

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12 December 2020

Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models

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12 December 2020

Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft.

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12 December 2020

Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB.

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12 December 2020

Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha

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12 December 2020

p53 and NF-kappaB crosstalk: IKKalpha tips the balance

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12 December 2020

Potent Inhibitors of Proteasome

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12 December 2020

Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling

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12 December 2020

Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.

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12 December 2020

Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL-1alpha, EGF and TGF-beta1 through NF-kappaB dependent and independent mechanisms

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12 December 2020

A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer

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12 December 2020

The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo

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12 December 2020

The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor?

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12 December 2020

Differential activation of peroxisome proliferator-activated receptors by eicosanoids.

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12 December 2020

NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis

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12 December 2020

Sulindac inhibits activation of the NF-kappaB pathway

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12 December 2020

Constitutive phosphorylation of I kappa B alpha by casein kinase II

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12 December 2020

Aspirin induces apoptosis in oesophageal cancer cells by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2

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12 December 2020

Inflammation and cancer: how hot is the link?

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12 December 2020

Systems biology-defined NF-kappaB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status

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12 December 2020

Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells.

1 reference

12 December 2020

Interleukin 6, a nuclear factor-kappaB target, predicts resistance to docetaxel in hormone-independent prostate cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity.

1 reference

12 December 2020

Nuclear factor-kappaB signature of inflammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-kappaB DNA-binding

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12 December 2020

A Phase I study of CHS 828 in patients with solid tumor malignancy

1 reference

12 December 2020

Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway

1 reference

12 December 2020

Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity

1 reference

12 December 2020

A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

1 reference

12 December 2020

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

1 reference

12 December 2020

Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen

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12 December 2020

Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

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12 December 2020

Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.

1 reference

12 December 2020

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

1 reference

12 December 2020

Antitumor activity of thalidomide in refractory multiple myeloma

1 reference

12 December 2020

Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models

1 reference

12 December 2020

Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells.

1 reference

12 December 2020

Inhibition of carcinogenesis by tea.

1 reference

12 December 2020

Proteasome inhibition: a novel approach to cancer therapy

1 reference

12 December 2020

Targeting the nuclear factor-kappaB rescue pathway has promising future in human renal cell carcinoma therapy

1 reference

12 December 2020

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

1 reference

12 December 2020

Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB.

1 reference

12 December 2020

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

1 reference

12 December 2020

Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

1 reference

12 December 2020

Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.

1 reference

12 December 2020

A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status

1 reference

12 December 2020

Protein kinase CK2: signaling and tumorigenesis in the mammary gland

1 reference

12 December 2020

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

1 reference

12 December 2020

Nf-kappa B, chemokine gene transcription and tumour growth

1 reference

12 December 2020

Effects of IKK inhibitor PS1145 on NF-kappaB function, proliferation, apoptosis and invasion activity in prostate carcinoma cells

1 reference

12 December 2020

Nuclear factor-kappaB in development, prevention, and therapy of cancer

1 reference

12 December 2020

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

1 reference

12 December 2020

Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells

1 reference

12 December 2020

Intracellular inhibitory effects of Velcade correlate with morphoproteomic expression of phosphorylated-nuclear factor-kappaB and p53 in breast cancer cell lines.

1 reference

12 December 2020

The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target

1 reference

12 December 2020

Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity

1 reference

12 December 2020

Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors

1 reference

12 December 2020

Kaurane diterpene, kamebakaurin, inhibits NF-kappa B by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-kappa B target genes

1 reference

12 December 2020

Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

1 reference

12 December 2020

Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells

1 reference

12 December 2020

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

1 reference

12 December 2020

Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice

1 reference

12 December 2020

Proteasome inhibitors: from research tools to drug candidates

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12 December 2020

Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

1 reference

12 December 2020

IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas.

1 reference

12 December 2020

Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kappaB signal pathway

1 reference

12 December 2020

Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma.

1 reference

12 December 2020

BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways

1 reference

12 December 2020

Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells

1 reference

12 December 2020

Synergistic effect of histone deacetylase inhibitors FK228 and m-carboxycinnamic acid bis-hydroxamide with proteasome inhibitors PSI and PS-341 against gastrointestinal adenocarcinoma cells

1 reference

12 December 2020

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

1 reference

12 December 2020

NF-kappaB functions as a tumour promoter in inflammation-associated cancer

1 reference

12 December 2020

Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer

1 reference

12 December 2020

Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells.

1 reference

12 December 2020

Gene expression profiling of lymphoid malignancies

1 reference

12 December 2020

NF-kappa B as a therapeutic target in multiple myeloma

1 reference

12 December 2020

Shared principles in NF-kappaB signaling

1 reference

12 December 2020

4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management

1 reference

12 December 2020

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

12 December 2020

Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.

1 reference

12 December 2020

The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression

1 reference

12 December 2020

Novel IKK inhibitors: beta-carbolines

1 reference

12 December 2020

10.1517/14728222.12.9.1109

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18694378%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18694378%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PubMed publication ID

18694378

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18694378%20AND%20SRC:MED&resulttype=core&format=json