(Q81636113)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18624678%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

review article

1 reference

title

The pregnane X receptor: from bench to bedside (English)

1 reference

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10 January 2020

Xiaochao Ma

1 reference

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10 January 2020

Jeffrey R Idle

series ordinal

1 reference

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10 January 2020

Frank J Gonzalez

series ordinal

1 reference

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10 January 2020

publication date

1 July 2008

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Expert Opinion on Drug Metabolism & Toxicology

10 January 2020

published in

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10 January 2020

volume

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10 January 2020

issue

1 reference

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10 January 2020

page(s)

895-908

1 reference

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Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

10 January 2020

cites work

1 reference

12 December 2020

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

1 reference

12 December 2020

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

1 reference

12 December 2020

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

1 reference

12 December 2020

PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides

1 reference

12 December 2020

A novel testosterone 6 beta-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro

1 reference

12 December 2020

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

1 reference

12 December 2020

Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines

1 reference

12 December 2020

Homology modelling of the nuclear receptors: human oestrogen receptorbeta (hERbeta), the human pregnane-X-receptor (PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor a

1 reference

12 December 2020

Regulation of UDP glucuronosyltransferase genes.

1 reference

12 December 2020

Requirements of different species for vitamins

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12 December 2020

The simultaneous use of rifampicin and other antitubercular agents with oral contraceptives

1 reference

12 December 2020

Information obtained by liver biopsy in 100 tuberculous patients

1 reference

12 December 2020

Liver steatogenic power of high doses of rifampicin in rats

1 reference

12 December 2020

Long term study of the effect of rifampicin and isoniazid on vitamin D metabolism

1 reference

12 December 2020

Effect of rifampicin treatment on hepatic drug metabolism and serum bile acids in patients with primary biliary cirrhosis

1 reference

12 December 2020

Ultrastructural changes in the parenchymal liver cells of rats treated with high doses of rifampicin

1 reference

12 December 2020

Jaundice caused by rifampicin: 3 cases

1 reference

12 December 2020

Effects of long-term rifampicin administration in primary biliary cirrhosis

1 reference

12 December 2020

Effects of 3-methylcholanthrene or diethyl maleate on the hepatotoxicity of acetaminophen

1 reference

12 December 2020

Acetaminophen hepatotoxicity: potentiation by isoniazid

1 reference

12 December 2020

cDNA-directed expression of human cytochrome P450 CYP3A4 using baculovirus.

1 reference

12 December 2020

Rifampin drastically reduces plasma concentrations and effects of oral midazolam

1 reference

12 December 2020

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1 reference

12 December 2020

Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies

1 reference

12 December 2020

Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones

1 reference

12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

12 December 2020

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

12 December 2020

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

12 December 2020

[Drug-induced osteomalacia]

1 reference

12 December 2020

Cytochrome P-450 3A4: regulation and role in drug metabolism

1 reference

12 December 2020

Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

1 reference

12 December 2020

The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue

1 reference

12 December 2020

Vitamin D2 is much less effective than vitamin D3 in humans

1 reference

12 December 2020

Enhanced acetaminophen toxicity by activation of the pregnane X receptor

1 reference

12 December 2020

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

1 reference

12 December 2020

CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development

1 reference

12 December 2020

Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease

1 reference

12 December 2020

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

1 reference

12 December 2020

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia

1 reference

12 December 2020

2004 drug approval highlights: FDA update

1 reference

12 December 2020

Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms.

1 reference

12 December 2020

Management of inflammatory bowel disease: does rifaximin offer any promise?

1 reference

12 December 2020

Potential role for human cytochrome P450 3A4 in estradiol homeostasis

1 reference

12 December 2020

An open-label evaluation of rifaximin in the treatment of active Crohn's disease

1 reference

12 December 2020

Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats

1 reference

12 December 2020

Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis

1 reference

12 December 2020

Rifampicin-induced elevation of serum bile acids in man.

1 reference

12 December 2020

Rifampicin and vitamin D metabolism

1 reference

12 December 2020

Structure and function of the human nuclear xenobiotic receptor PXR.

1 reference

12 December 2020

Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia

1 reference

12 December 2020

Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma

1 reference

12 December 2020

LXRS and FXR: the yin and yang of cholesterol and fat metabolism

1 reference

12 December 2020

The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease

1 reference

12 December 2020

Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells

1 reference

12 December 2020

Rifaximin for active ulcerative colitis

1 reference

12 December 2020

A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway

1 reference

12 December 2020

Pharmacokinetic modelling of the interaction between St John's wort and ciclosporin A.

1 reference

12 December 2020

Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro.

1 reference

12 December 2020

Functional evolution of the pregnane X receptor

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12 December 2020

Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies.

1 reference

12 December 2020

The antiapoptotic role of pregnane X receptor in human colon cancer cells

1 reference

12 December 2020

Pregnane X receptor is essential for normal progression of liver regeneration

1 reference

12 December 2020

Estrogens and antiestrogens activate hPXR.

1 reference

12 December 2020

Drug-activated nuclear receptors CAR and PXR.

1 reference

12 December 2020

Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

1 reference

12 December 2020

The nuclear pregnane X receptor regulates xenobiotic detoxification

1 reference

12 December 2020

Pharmacokinetic interactions with rifampicin : clinical relevance

1 reference

12 December 2020

Expression and potential roles of pregnane X receptor in endometrial cancer

1 reference

12 December 2020

Induction of ABCC3 (MRP3) by pregnane X receptor activators

1 reference

12 December 2020

Homologous metabolic and gene activating routes for vitamins E and K.

1 reference

12 December 2020

Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.

1 reference

12 December 2020

Hepatocyte Nuclear Factor 4α Is a Central Regulator of Bile Acid Conjugation

1 reference

12 December 2020

Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes.

1 reference

12 December 2020

Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure

1 reference

12 December 2020

Urinary 6beta-hydroxycortisol/17-hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction

1 reference

12 December 2020

Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays

1 reference

12 December 2020

Hyperforin content determines the magnitude of the St John's wort-cyclosporine drug interaction.

1 reference

12 December 2020

Pregnane X receptor and natural products: beyond drug-drug interactions

1 reference

12 December 2020

Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.

1 reference

12 December 2020

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

1 reference

12 December 2020

Effects of budesonide on P-glycoprotein expression in intestinal cell lines

1 reference

12 December 2020

Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression

1 reference

12 December 2020

T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

1 reference

12 December 2020

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition

1 reference

12 December 2020

The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators

1 reference

12 December 2020

The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology

1 reference

12 December 2020

Rifaximin is a gut-specific human pregnane X receptor activator

1 reference

12 December 2020

Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene

1 reference

12 December 2020

Human pregnane X receptor and resistance to chemotherapy in prostate cancer

1 reference

12 December 2020

Role of the PXR gene locus in inflammatory bowel diseases

1 reference

12 December 2020

Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis

1 reference

12 December 2020

Acute heart transplant rejection due to Saint John's wort

1 reference

12 December 2020

Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

12 December 2020

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

12 December 2020

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

1 reference

12 December 2020

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

1 reference

12 December 2020

Pharmacokinetic Interaction between amprenavir and rifabutin or rifampin in healthy males

1 reference

12 December 2020

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

1 reference

12 December 2020

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

1 reference

12 December 2020

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

12 December 2020

The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected patients

1 reference

12 December 2020

Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.

1 reference

12 December 2020

Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors

1 reference

12 December 2020

Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol

1 reference

12 December 2020

Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor

1 reference

12 December 2020

Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis.

1 reference

12 December 2020

Structural insights into the promiscuity and function of the human pregnane X receptor

1 reference

12 December 2020

Identifiers

DOI

10.1517/17425255.4.7.895

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18624678%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

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10 January 2020

PubMed publication ID

18624678

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18624678%20AND%20SRC:MED&resulttype=core&format=json