(Q75312802)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

review article

1 reference

title

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Saïd M Sebti

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Channing J Der

series ordinal

1 reference

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17 November 2019

publication date

1 December 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

published in

Nature Reviews Cancer

1 reference

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17 November 2019

volume

1 reference

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17 November 2019

issue

1 reference

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17 November 2019

page(s)

945-951

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124%20AND%20SRC:MED&resulttype=core&format=json

Understanding Ras: 'it ain't over 'til it's over'.

17 November 2019

cites work

1 reference

31 March 2020

RHO-GTPases and cancer

1 reference

Rig is a novel Ras-related protein and potential neural tumor suppressor

31 March 2020

1 reference

RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer

31 March 2020

1 reference

DBC2, a candidate for a tumor suppressor gene involved in breast cancer

31 March 2020

1 reference

NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas

31 March 2020

1 reference

Ras family signaling: therapeutic targeting

31 March 2020

1 reference

Targeting RAS signalling pathways in cancer therapy

31 March 2020

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31 March 2020

1 reference

Anticancer activity of farnesyltransferase and geranylgeranyltransferase I inhibitors: prospects for drug development.

31 March 2020

1 reference

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

31 March 2020

1 reference

Inhibition of ras prenylation: A novel approach to cancer chemotherapy

31 March 2020

1 reference

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

31 March 2020

1 reference

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

31 March 2020

1 reference

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

31 March 2020

1 reference

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

31 March 2020

1 reference

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

31 March 2020

1 reference

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

31 March 2020

1 reference

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

31 March 2020

1 reference

Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth

31 March 2020

1 reference

Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II--preclinical studies in a nude mouse model.

31 March 2020

1 reference

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

31 March 2020

1 reference

Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf

31 March 2020

1 reference

The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner

31 March 2020

1 reference

Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

31 March 2020

1 reference

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

31 March 2020

1 reference

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

31 March 2020

1 reference

Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

31 March 2020

1 reference

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

31 March 2020

1 reference

Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors

31 March 2020

1 reference

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

31 March 2020

1 reference

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

31 March 2020

1 reference

High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors

31 March 2020

1 reference

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

31 March 2020

1 reference

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

31 March 2020

1 reference

CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB

31 March 2020

1 reference

Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

31 March 2020

1 reference

RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

31 March 2020

1 reference

RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells

31 March 2020

1 reference

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

31 March 2020

1 reference

RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody

31 March 2020

1 reference

The expression of rho proteins decreases with human brain tumor progression: potential tumor markers

31 March 2020

1 reference

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

31 March 2020

1 reference

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

31 March 2020

1 reference

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein

31 March 2020

1 reference

RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription.

31 March 2020

1 reference

Functional proteomics analysis of GTPase signaling networks

31 March 2020

1 reference

Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases

31 March 2020

1 reference

Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome

31 March 2020

1 reference

Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene

31 March 2020

1 reference

A phosphatase associated with metastasis of colorectal cancer

31 March 2020

1 reference

RhoE regulates actin cytoskeleton organization and cell migration.

31 March 2020

1 reference

A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion

31 March 2020

1 reference

Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

31 March 2020

1 reference

RhoE binds to ROCK I and inhibits downstream signaling

31 March 2020

1 reference

Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway

31 March 2020

1 reference

31 March 2020

1 reference

Rheb promotes cell growth as a component of the insulin/TOR signalling network

31 March 2020

1 reference

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

31 March 2020

1 reference

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

31 March 2020

1 reference

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

31 March 2020

1 reference

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

31 March 2020

1 reference

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

31 March 2020

1 reference

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

31 March 2020

1 reference

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

31 March 2020

1 reference

Drosophila Rheb GTPase is required for cell cycle progression and cell growth

31 March 2020

1 reference

A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb

31 March 2020

1 reference