(Q73596145)

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Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo

scientific article published on August 22, 1997

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261113%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261113%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo (English)

1 reference

10.1074/JBC.272.34.21096

https://api.crossref.org/works/10.1074/JBC.272.34.21096

11 November 2024

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J. W. Pierce

1

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11 November 2024

R. Schoenleber

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9261113

11 November 2024

G. Jesmok

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9261113

11 November 2024

J. Best

4

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11 November 2024

S. A. Moore

5

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11 November 2024

T. Collins

6

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11 November 2024

M. E. Gerritsen

7

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11 November 2024

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1 August 1997

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5 November 2019

22 August 1997

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9261113

11 November 2024

full work available at URL

http://www.jbc.org/article/S0021925819657285/pdf

online access status

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11 November 2024

https://api.elsevier.com/content/article/PII:S0021925819657285?httpAccept=text/xml

1 reference

10.1074/JBC.272.34.21096

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11 November 2024

https://api.elsevier.com/content/article/PII:S0021925819657285?httpAccept=text/plain

1 reference

10.1074/JBC.272.34.21096

https://api.crossref.org/works/10.1074/JBC.272.34.21096

11 November 2024

https://syndication.highwire.org/content/doi/10.1074/jbc.272.34.21096

1 reference

10.1074/JBC.272.34.21096

https://api.crossref.org/works/10.1074/JBC.272.34.21096

11 November 2024

Journal of Biological Chemistry

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Europe PubMed Central

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5 November 2019

272

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5 November 2019

34

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5 November 2019

21096-21103

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Europe PubMed Central

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5 November 2019

Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration

1

1 reference

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11 November 2024

Cytokines and endothelial cell biology

2

1 reference

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11 November 2024

Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)

6

1 reference

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Functional analysis of the human vascular cell adhesion molecule 1 promoter

7

1 reference

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11 November 2024

NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation

8

1 reference

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Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.

11

1 reference

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Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kappa B site and p65 homodimers

12

1 reference

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NF-kappa B and Rel: participants in a multiform transcriptional regulatory system.

13

1 reference

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11 November 2024

Structure, regulation and function of NF-kappa B

14

1 reference

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11 November 2024

NF-kappa B: a lesson in family values

15

1 reference

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Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

17

1 reference

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11 November 2024

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

18

1 reference

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11 November 2024

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

19

1 reference

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11 November 2024

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

20

1 reference

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

22

1 reference

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11 November 2024

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

23

1 reference

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11 November 2024

Function and activation of NF-kappa B in the immune system

24

1 reference

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Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines

25

1 reference

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11 November 2024

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

27

1 reference

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Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals

30

1 reference

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Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells

31

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Inhibition of NF-kappa B by sodium salicylate and aspirin

32

1 reference

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11 November 2024

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor

33

1 reference

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11 November 2024

Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors

34

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Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability

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11 November 2024

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

39

1 reference

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

41

1 reference

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In vivo stimulation of I kappa B phosphorylation is not sufficient to activate NF-kappa B

43

1 reference

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Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation

44

1 reference

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Constitutive phosphorylation of I kappa B alpha by casein kinase II

45

1 reference

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Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha

46

1 reference

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Identification of signal-induced IkappaB-alpha kinases in human endothelial cells

47

1 reference

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

48

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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The stress-activated protein kinase subfamily of c-Jun kinases

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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MAPKs: new JNK expands the group

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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

56

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Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways

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Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation

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MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.

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Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

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MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1

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Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and -independent mitogen-activated protein kinase cascades

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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

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A common theme in endothelial activation Insights from the structural analysis of the genes for E-selectin and VCAM-1.

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Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

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Involvement of a Putative Protein-tyrosine Phosphatase and IκB-α Serine Phosphorylation in Nuclear Factor κB Activation by Tumor Necrosis Factor

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Identifiers

10.1074/JBC.272.34.21096

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261113%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261113%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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