(Q699997)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signaling receptor binding

1 reference

1 January 2018

Recombinant human bone morphogenetic protein induces bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

phosphatase activator activity

1 reference

1 January 2018

Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

BMP receptor binding

1 reference

24 April 2018

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

protein binding

15 references

1 January 2018

Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Agrin binds BMP2, BMP4 and TGFbeta1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Molecular recognition of BMP-2 and BMP receptor IA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Structure of the ternary signaling complex of a TGF-beta superfamily member

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Crystal structure of the BMP-2-BRIA ectodomain complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

SMAD binding

1 reference

1 January 2018

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

protein heterodimerization activity

1 reference

1 January 2018

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

transforming growth factor beta receptor binding

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cell component

cell surface

1 reference

1 January 2018

Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

BMP receptor complex

1 reference

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

3 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 reference

1 January 2018

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

4 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

skeletal system development

biological process

1 reference

1 January 2018

Recombinant human bone morphogenetic protein induces bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of protein phosphorylation

mesenchyme development

1 reference

1 January 2018

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of cell cycle

1 reference

1 January 2018

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

protein phosphorylation

1 reference

1 January 2018

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

proteoglycan metabolic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

mesenchymal cell differentiation

1 reference

1 January 2018

Regulation of BMP7 expression during kidney development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of ERK1 and ERK2 cascade

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

BMP signaling pathway involved in heart induction

1 reference

1 January 2018

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cardiocyte differentiation

negative regulation of canonical Wnt signaling pathway

IEP

1 reference

1 January 2018

BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of cell population proliferation

IEP

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of p38MAPK cascade

1 reference

1 January 2018

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

pathway-restricted SMAD protein phosphorylation

regulation of transcription, DNA-templated

1 reference

1 January 2018

DRAGON, a bone morphogenetic protein co-receptor

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

SMAD protein signal transduction

1 reference

24 April 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

ossification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 reference

1 January 2018

regulation of odontogenesis of dentin-containing tooth

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of transcription, DNA-templated

telencephalon development

2 references

1 reference

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of Wnt signaling pathway involved in heart development

1 reference

1 January 2018

Gremlin enhances the determined path to cardiomyogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cartilage development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 reference

1 January 2018

bone mineralization involved in bone maturation

1 reference

1 January 2018

Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of steroid biosynthetic process

1 reference

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of MAPK cascade

1 reference

1 January 2018

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 reference

1 January 2018

chondrocyte differentiation

1 reference

1 January 2018

BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of bone mineralization

2 references

10 September 2018

MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

10 September 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

cellular response to organic cyclic compound

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of transcription by RNA polymerase II

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

positive regulation of phosphatase activity

1 reference

1 January 2018

Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of calcium-independent cell-cell adhesion

1 reference

1 January 2018

BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of osteoblast differentiation

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

protein destabilization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

osteoblast differentiation

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The role of histone chaperones in osteoblastic differentiation of C2C12 myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

epithelial to mesenchymal transition

positive regulation of protein binding

1 reference

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of transcription, DNA-templated

1 reference

1 January 2018

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

1 reference

1 January 2018

The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of aldosterone biosynthetic process

1 reference

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of endothelial cell proliferation

1 reference

1 January 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of cortisol biosynthetic process

1 reference

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cell-cell signaling

1 reference

1 January 2018

Recombinant human bone morphogenetic protein induces bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of pathway-restricted SMAD protein phosphorylation

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

cellular response to growth factor stimulus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cellular response to BMP stimulus

endocardial cushion morphogenesis

ISS

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 reference

1 January 2018

negative regulation of cardiac muscle cell differentiation

1 reference

1 January 2018

Gremlin enhances the determined path to cardiomyogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of apoptotic process

1 reference

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of insulin-like growth factor receptor signaling pathway

1 reference

1 January 2018

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of transcription by RNA polymerase II

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

cardiac epithelial to mesenchymal transition

1 reference

1 January 2018

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of gene expression

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

BMP signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

10 references

24 April 2018

24 April 2018

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

IGI

24 April 2018

BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

24 April 2018

The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12643&geneProductId=UniProtKB:P12643

cell development

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

regulation of signaling receptor activity

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

negative regulation of transcription by RNA polymerase II

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

response to bacterium

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

positive regulation of pathway-restricted SMAD protein phosphorylation

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

BMP signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

11 references

1 January 2018

1 January 2018

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

IGI

1 January 2018

BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

The Canonical BMP Signaling Pathway Plays a Crucial Part in Stimulation of Dentin Sialophosphoprotein Expression by BMP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

regulation of apoptotic process

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

regulation of MAPK cascade

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

SMAD protein signal transduction

positive regulation of bone mineralization

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

1 January 2018

MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12643

http://purl.uniprot.org/uniprot/P12643

Gene Atlas image

PBB GE BMP2 205289 at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Transforming growth factor beta, conserved site

Identifiers.org

has part(s)

1 reference

Transforming growth factor-beta, C-terminal

1 reference

TGF-beta, propeptide

1 reference

Identifiers

MeSH descriptor ID

D055396

subject named as

Bone Morphogenetic Protein 2

0 references

MeSH tree code

D12.644.276.954.200.200

0 references

D12.776.467.942.200.200

0 references

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

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9 August 2016

1 reference

9 August 2016

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9 August 2016

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9 August 2016

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9 August 2016

1 reference

9 August 2016

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9 August 2016

1 reference

9 August 2016

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9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023