(Q68164526)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1980062%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

review article

1 reference

title

Molecular mechanisms of drug resistance (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1980062%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

J D Hayes

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22 September 2019

C R Wolf

series ordinal

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22 September 2019

publication date

1 December 1990

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22 September 2019

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22 September 2019

volume

272

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22 September 2019

issue

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22 September 2019

page(s)

281-295

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Methotrexate-resistant Leishmania donovani genetically deficient in the folate-methotrexate transporter

22 September 2019

cites work

1 reference

12 December 2020

Heat shock and the heat shock proteins

1 reference

12 December 2020

A mechanism of resistance to 6-mercaptopurine: metabolism of hypoxanthine and 6-mercaptopurine by sensitive and resistant neoplasms.

1 reference

12 December 2020

The Garrod lecture. The influence of 6-aminopenicillanic acid on antibiotic development

1 reference

12 December 2020

Circumvention of resistance to anthracyclines by calcium antagonists and other membrane-perturbing agents

1 reference

12 December 2020

A new mechanism of plasmid trimethoprim resistance. Characterization of an inducible dihydrofolate reductase.

1 reference

12 December 2020

Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification

1 reference

12 December 2020

Association of the dioxin receptor with the Mr 90,000 heat shock protein: a structural kinship with the glucocorticoid receptor

1 reference

12 December 2020

Resistance of the antibiotic target site

1 reference

12 December 2020

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells

1 reference

12 December 2020

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1 reference

12 December 2020

Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats

1 reference

12 December 2020

R-factor mediated gentamicin resistance: A new enzyme which modifies aminoglycoside antibiotics

1 reference

12 December 2020

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals.

1 reference

12 December 2020

Transformation related expression of glutathione-S-transferase P in rat liver cells

1 reference

12 December 2020

Multidrug-resistance phenotype in Chinese hamster ovary cells

1 reference

12 December 2020

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells

1 reference

12 December 2020

Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine

1 reference

12 December 2020

Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil

1 reference

12 December 2020

The H circles of Leishmania tarentolae are a unique amplifiable system of oligomeric DNAs associated with drug resistance.

1 reference

12 December 2020

Aminoglycoside resistance in bacteria medicated by gentamicin acetyltransferase II, an enzyme modifying the 2'-amino group of aminoglycoside antibiotics.

1 reference

12 December 2020

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

1 reference

12 December 2020

Multidrug resistance during chemical carcinogenesis: a mechanism revealed?

1 reference

12 December 2020

The SOS regulatory system of Escherichia coli

1 reference

12 December 2020

Nonspecific Induction of -lactamase in Enterobacter cloacae

1 reference

12 December 2020

Partial reversal of doxorubicin resistance by forskolin and 1,9-dideoxyforskolin in murine sarcoma S180 variants

1 reference

12 December 2020

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

1 reference

12 December 2020

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1 reference

12 December 2020

Characterization of a camptothecin-resistant human DNA topoisomerase I

1 reference

12 December 2020

Preferential over-expression of the class alpha rat Ya2 glutathione S-transferase subunit in livers bearing aflatoxin-induced pre-neoplastic nodules. Comparison of the primary structures of Ya1 and Ya2 with cloned class alpha glutathione S-transfera

1 reference

12 December 2020

Mechanism of Tetracycline Resistance in Staphylococcus aureus

1 reference

12 December 2020

Approaches to drug selectivity in cancer therapy on the basis of differences between membranes of normal vs. neoplastic cells.

1 reference

12 December 2020

Glutathione, glutathione S-transferases, and related redox enzymes in Adriamycin-resistant cell lines with a multidrug resistant phenotype

1 reference

12 December 2020

Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan

1 reference

12 December 2020

OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins

1 reference

12 December 2020

Adriamycin resistance, heat resistance and radiation response in Chinese hamster fibroblasts.

1 reference

12 December 2020

Outer membrane permeation of beta-lactam antibiotics in Escherichia coli, Proteus mirabilis, and Enterobacter cloacae

1 reference

12 December 2020

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line

1 reference

12 December 2020

Transport of Nitrogen Mustard on the Transport-Carrier for Choline in L5178Y Lymphoblasts

1 reference

12 December 2020

1 reference

12 December 2020

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

1 reference

12 December 2020

Cytogenetic analysis of the cSOD microregion in Drosophila melanogaster

1 reference

12 December 2020

Cloning of cDNA for argininosuccinate synthetase mRNA and study of enzyme overproduction in a human cell line

1 reference

12 December 2020

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16

1 reference

12 December 2020

Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells

1 reference

12 December 2020

Metabolic basis of the species difference to aflatoxin B1 induced hepatotoxicity

1 reference

12 December 2020

The success of plasmid-encoded resistance genes in clinical bacteria. An examination of plasmid-mediated ampicillin and trimethoprim resistance genes and their resistance mechanisms

1 reference

12 December 2020

Potentiation of doxorubicin cytotoxicity by the calcium antagonist bepridil in anthracycline-resistant and -sensitive cell lines. A comparison with verapamil.

1 reference

12 December 2020

Heat shock proteins in thermotolerance and other cellular processes

1 reference

12 December 2020

Bacterial resistance to antifolate chemotherapeutic agents mediated by plasmids

1 reference

12 December 2020

Chloramphenicol resistance that does not involve chloramphenicol acetyltransferase encoded by plasmids from gram-negative bacteria

1 reference

12 December 2020

Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis

1 reference

12 December 2020

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1 reference

12 December 2020

Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine

1 reference

12 December 2020

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria

1 reference

12 December 2020

Effects of the resistance plasmid R124 on the level of the OmpF outer membrane protein and on the response ofEscherichia colito environmental agents

1 reference

12 December 2020

Phorbol esters induce multidrug resistance in human breast cancer cells

1 reference

12 December 2020

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1 reference

12 December 2020

Clinical pharmacology of l-β-D-arabinofuranosyl cytosine

1 reference

12 December 2020

Self defence in antibiotic-producing organisms

1 reference

12 December 2020

Induction of heat shock gene expression without heat shock by hepatocarcinogens and during hepatic regeneration in rat liver

1 reference

12 December 2020

Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.

1 reference

12 December 2020

Identification of cytosolic peroxisome proliferator binding protein as a member of the heat shock protein HSP70 family

1 reference

12 December 2020

Acetylcholine receptor structure, function, and evolution

1 reference

12 December 2020

groEL and dnaK genes of Escherichia coli are induced by UV irradiation and nalidixic acid in an htpR+-dependent fashion

1 reference

12 December 2020

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells

1 reference

12 December 2020

3-N Enzymatic Acetylation of Gentamicin, Tobramycin, and Kanamycin by Escherichia coli Carrying an R Factor

1 reference

12 December 2020

Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton

1 reference

12 December 2020

Bacterial resistance to chloramphenicol

1 reference

12 December 2020

Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes.

1 reference

12 December 2020

Mechanisms regulating cell resistance to adriamycin. Evidence that drug accumulation in resistant cells is modulated by phosphorylation of a plasma membrane glycoprotein

1 reference

12 December 2020

Ethanol-induced tolerance to heat and to adriamycin

1 reference

12 December 2020

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity

1 reference

12 December 2020

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II

1 reference

12 December 2020

In situ selection of a human rhabdomyosarcoma resistant to vincristine with altered beta-tubulins.

1 reference

12 December 2020

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1 reference

12 December 2020

Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards

1 reference

12 December 2020

Mediation of multi-drug resistance in a Chinese hamster ovary cell line by a mutant type II topoisomerase

1 reference

12 December 2020

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells

1 reference

12 December 2020

The multidrug transporter, a double-edged sword

1 reference

12 December 2020

Biological markers characterizing the development of preneoplastic and neoplastic lesions in rodent liver

1 reference

12 December 2020

Isolation and expression of a complementary DNA that confers multidrug resistance

1 reference

12 December 2020

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells

1 reference

12 December 2020

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells

1 reference

12 December 2020

Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells

1 reference

12 December 2020

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1 reference

12 December 2020

Amino acid-conferred protection against melphalan--characterization of melphalan transport and correlation of uptake with cytotoxicity in cultured L1210 murine leukemia cells

1 reference

12 December 2020

Isolation and characterization of a Chinese hamster ovary cell line resistant to bifunctional nitrogen mustards

1 reference

12 December 2020

Structural and functional alterations in microtubule protein from Chinese hamster ovary cell mutants

1 reference

12 December 2020

Inducible DNA repair systems

1 reference

12 December 2020

Amplification of the gene for histidyl-tRNA synthetase in histidinol-resistant Chinese hamster ovary cells

1 reference

12 December 2020

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies

1 reference

12 December 2020

Characterization of beta-lactamase induction in Enterobacter cloacae

1 reference

12 December 2020

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1 reference

12 December 2020

The heat-shock response

1 reference

12 December 2020

Antibiotic resistance resulting from decreased drug accumulation

1 reference

12 December 2020

Oxygen toxicity: augmentation of antioxidant defense mechanisms in rat lung

1 reference

12 December 2020

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1 reference

12 December 2020

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

1 reference

12 December 2020

Drug resistance and DNA repair

1 reference

12 December 2020

Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: mutants deficient in thiols and mutants constitutive for the adaptive response.

1 reference

12 December 2020

Altered penicillin-binding proteins in methicillin-resistant strains of Staphylococcus aureus

1 reference

12 December 2020

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

1 reference

12 December 2020

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas

1 reference

12 December 2020

Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae

1 reference

12 December 2020

1 reference

12 December 2020

MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS.

1 reference

12 December 2020

Escherichia coli resistance to β-lactam antibiotics through a decrease in the affinity of a target for lethality

1 reference

12 December 2020

Transport of melphalan by sensitive and resistant L1210 cells

1 reference

12 December 2020

Pre-cancerous steps in carcinogenesis. Their physiological adaptive nature.

1 reference

12 December 2020

A Trypanosoma brucei mutant resistant to alpha-difluoromethylornithine.

1 reference

12 December 2020

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1 reference

12 December 2020

Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus

1 reference

12 December 2020

Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics.

1 reference

12 December 2020

The role of glutathione in determining the response of normal and tumor cells to anticancer drugs

1 reference

12 December 2020

Mutants of chinese hamster ovary cells affected in two different microtubule-associated proteins. Genetic and biochemical studies

1 reference

12 December 2020

Microbial resistance to newer generation beta-lactam antibiotics: clinical and laboratory implications

1 reference

12 December 2020

70K heat shock related proteins stimulate protein translocation into microsomes

1 reference

12 December 2020

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies

1 reference

12 December 2020

Gentamicin uptake in wild-type and aminoglycoside-resistant small-colony mutants of Staphylococcus aureus

1 reference

12 December 2020

Evidence that adriamycin resistance in Chinese hamster lung cells is regulated by phosphorylation of a plasma membrane glycoprotein

1 reference

12 December 2020

Mechanisms of resistance to fusidic acid in Staphylococcus aureus

1 reference

12 December 2020

Glutathione conjugation. An enzymatic basis for atrazine resistance in corn

1 reference

12 December 2020

Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate

1 reference

12 December 2020

Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer

1 reference

12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

12 December 2020

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1 reference

12 December 2020

Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis

1 reference

12 December 2020

The structure of β-lactamases

1 reference

12 December 2020

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component

1 reference

12 December 2020

Multidrug resistance in the laboratory and clinic

1 reference

12 December 2020

Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria

1 reference

12 December 2020

Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation

1 reference

12 December 2020

Altered mouse bone marrow glutathione and glutathione transferase levels in response to cytotoxins

1 reference

12 December 2020

Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil

1 reference

12 December 2020

The multistep nature of cancer development.

1 reference

12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

12 December 2020

Ribosomal proteins. 33. Location of amino-acid replacements in protein S12 isolated from Escherichia coli mutants resistant to streptomycin

1 reference

12 December 2020

Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts

1 reference

12 December 2020

The biochemistry of P-glycoprotein-mediated multidrug resistance

1 reference

12 December 2020

Basis for natural variation in sensitivity to 5-fluorouracil in mouse and human cells in culture.

1 reference

12 December 2020

Resistance to the antibiotics viomycin and capreomycin in the Streptomyces species which produce them

1 reference

12 December 2020

Overexpression of metallothionein confers resistance to anticancer drugs.

1 reference

12 December 2020

Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver.

1 reference

12 December 2020

The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene

1 reference

12 December 2020

Amplification and cloning of the Chinese hamster glutamine synthetase gene

1 reference

12 December 2020

Hsp70 accelerates the recovery of nucleolar morphology after heat shock.

1 reference

12 December 2020

Phosphorylation of the multidrug resistance associated glycoprotein.

1 reference

12 December 2020

CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin

1 reference

12 December 2020

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein

1 reference

12 December 2020

Mechanisms of multidrug resistance and implications for therapy

1 reference

12 December 2020

Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture

1 reference

12 December 2020

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

1 reference

12 December 2020

Nucleotide sequence analysis of the Drosophila small heat shock gene cluster at locus 67B

1 reference

12 December 2020

Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin

1 reference

12 December 2020

Aminoglycoside resistance

1 reference

12 December 2020

Genetics of multidrug resistance: relationship of a cloned gene to the complete multidrug resistant phenotype.

1 reference

12 December 2020

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1 reference

12 December 2020

A rifampicin resistent rna-polymerase from E. coli altered in the beta-subunit

1 reference

12 December 2020

Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins

1 reference

12 December 2020

Enzymatic mechanisms of resistance to alkylating agents in tumor cells and normal tissues

1 reference

12 December 2020

A regulatory upstream promoter element in the Drosophila hsp 70 heat-shock gene.

1 reference

12 December 2020

Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family

1 reference

12 December 2020

Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

1 reference

12 December 2020

Beta-lactamases: molecular studies

1 reference

12 December 2020

A new pathway for DNA repair in Escherichia coli

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ2720281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1980062%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1980062%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

PubMed publication ID

1980062

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1980062%20AND%20SRC:MED&resulttype=core&format=json