(Q64888205)

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APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

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Europe PubMed Central

PMC publication ID

30 June 2019

http://europepmc.org/abstract/PMC/6023751

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. (English)

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Europe PubMed Central

PMC publication ID

30 June 2019

http://europepmc.org/abstract/PMC/6023751

Alzheimer's disease

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inferred from title

11

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

21

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Li-Huei Tsai

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

author name string

Yuan-Ta Lin

1

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

Jinsoo Seo

2

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

Fan Gao

3

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

Heather M Feldman

4

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

Hsin-Lan Wen

5

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

Jay Penney

6

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Hugh P Cam

7

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Elizabeta Gjoneska

8

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Waseem K Raja

9

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30 June 2019

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Jemmie Cheng

10

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30 June 2019

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Oleg Kritskiy

12

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30 June 2019

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Fatema Abdurrob

13

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Zhuyu Peng

14

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Blerta Milo

15

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Chung Jong Yu

16

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Sara Elmsaouri

17

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

Dilip Dey

18

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Tak Ko

19

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30 June 2019

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Bruce A Yankner

20

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http://europepmc.org/abstract/PMC/6023751

publication date

31 May 2018

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http://europepmc.org/abstract/PMC/6023751

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

98

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

6

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

1141-1154.e7

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Europe PubMed Central

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30 June 2019

http://europepmc.org/abstract/PMC/6023751

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6023751/fullTextXML

based on heuristic

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/29861287

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Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

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Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization

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CNS synaptogenesis promoted by glia-derived cholesterol

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Role of glia-derived cholesterol in synaptogenesis: new revelations in the synapse-glia affair.

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Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

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Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

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https://pubmed.ncbi.nlm.nih.gov/29861287

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

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Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss

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Protein sensors for membrane sterols

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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ApoE plasma levels and risk of cardiovascular mortality in old age

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

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Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts

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Model-based analysis of ChIP-Seq (MACS)

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https://pubmed.ncbi.nlm.nih.gov/29861287

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WGCNA: an R package for weighted correlation network analysis

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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The role of apolipoprotein E in Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

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https://pubmed.ncbi.nlm.nih.gov/29861287

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Fast and accurate long-read alignment with Burrows-Wheeler transform

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ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

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https://pubmed.ncbi.nlm.nih.gov/29861287

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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Role of astrocytes in brain function and disease

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Integrative genomics viewer

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https://pubmed.ncbi.nlm.nih.gov/29861287

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Neuronal activity regulates the regional vulnerability to amyloid-β deposition

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Matrix eQTL: ultra fast eQTL analysis via large matrix operations

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https://pubmed.ncbi.nlm.nih.gov/29861287

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IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype

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12 December 2020

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STAR: ultrafast universal RNA-seq aligner

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Rapid single-step induction of functional neurons from human pluripotent stem cells

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https://pubmed.ncbi.nlm.nih.gov/29861287

12 December 2020

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Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

1 reference

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Genome engineering using the CRISPR-Cas9 system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

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Associations Between ApoEε4 Carrier Status and Serum BDNF Levels--New Insights into the Molecular Mechanism of ApoEε4 Actions in Alzheimer's Disease

1 reference

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1 reference

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Rapid neurogenesis through transcriptional activation in human stem cells.

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1 reference

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Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

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Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease

1 reference

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Direct Transcriptional Effects of Apolipoprotein E

1 reference

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12 December 2020

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence

1 reference

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1 reference

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1 reference

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Gamma frequency entrainment attenuates amyloid load and modifies microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

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ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

1 reference

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based on heuristic

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APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

1 reference

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Cell diversity and network dynamics in photosensitive human brain organoids.

1 reference

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1 reference

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1 reference

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based on heuristic

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A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

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Microglia in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

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based on heuristic

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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

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based on heuristic

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Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/29861287

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Identifiers

10.1016/J.NEURON.2018.05.008

1 reference

Europe PubMed Central

PMC publication ID

30 June 2019

http://europepmc.org/abstract/PMC/6023751

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

30 June 2019

http://europepmc.org/abstract/PMC/6023751

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

30 June 2019

http://europepmc.org/abstract/PMC/6023751

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