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Wikidata

(Q5971562)

English

Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

mammalian protein found in Homo sapiens

  • NF-kappa-B essential modifier
  • IKKAP1
  • ikB kinase subunit gamma
  • NF-kappa-B essential modulator
  • IKBKG
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  • IKKG
  • IKK-gamma
  • Inhibitor of nuclear factor kappa-B kinase subunit gamma
  • I-kappa-B kinase subunit gamma
  • ikB kinase-associated protein 1
  • incontinentia pigmenti
  • FIP-3
  • inhibitor of nuclear factor kappa B kinase subunit gamma
In more languages
default for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
56 references
retrieved
8 April 2019
stated in
TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers
GOA
curator
UniProt
UniProt protein ID
Q9Y6K9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma
GOA
curator
UniProt
UniProt protein ID
Q9Y6K9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth
GOA
curator
UniProt
UniProt protein ID
Q9Y6K9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1)
GOA
curator
UniProt
UniProt protein ID
Q9Y6K9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase
GOA
curator
UniProt
UniProt protein ID
Q9Y6K9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structure of inhibitor of κB kinase β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of IkappaB kinase by vaccinia virus virulence factor B14
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Theileria-induced constitutive IKK activation is independent of functional Hsp90
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hepatitis B virus polymerase suppresses NF-κB signaling by inhibiting the activity of IKKs via interaction with Hsp90β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding of manumycin A inhibits IkappaB kinase beta activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Expanding the substantial interactome of NEMO using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
NEMO stabilizes c‐Myc through direct interaction in the nucleus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
retrieved
8 April 2019
stated in
A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6K9
determination method or standard
IPI
cell component
biological process
Gene Atlas image
PBB GE IKBKG 36004 at fs.png
732 × 530; 11 KB
0 references

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q5971562&oldid=2022908572"